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The map label for this gene is purM [H]

Identifier: 159901366

GI number: 159901366

Start: 6186585

End: 6187613

Strand: Reverse

Name: purM [H]

Synonym: Haur_4855

Alternate gene names: 159901366

Gene position: 6187613-6186585 (Counterclockwise)

Preceding gene: 159901367

Following gene: 159901365

Centisome position: 97.5

GC content: 52.58

Gene sequence:

>1029_bases
ATGACCACCTATAAGGATGCTGGCGTTGATATTGCAACCAAAATGGATGCGATCCAACAGATGGGAGCCGCAGTTAAGGC
CACCCATACGCCAGCAGTGTTGGCAGGTTTAGGCGCGTTTGGCGGCTGTTTTGATTTGGCTCAGGTTAATGCAAGCCATG
CGCAGCCAGTTTTGGTAGCCTCGACCGATGGGGTTGGCACCAAAACAGCGGTGGCCGCAGCCGTTGGCGATGTACGCACG
ATTGGCGCAGATCTCGTTAACCATTGTATTAATGATATTTTGTGCCAAGGCGCAACGCCACTCTTTTTTCTCGATTATAT
TGCGGCCTCAAAGCTTGAGCCAGCCATGGTTGTGGCCGCAGTTGAGGGGCTAGCAGCAGCCTGTCGTGATGCAGGAATTG
CCTTGCTTGGCGGCGAAACTGCCGAAATGCCAGGCGTTTACCACGATGGAGCCTTTGATGTAGCAGGAACAATCGTCGGT
GTGGTTGATCGGGCGCATATGCTTGATGGCAGCGCAATTAAGCCAGGTGATGTGGCAATTGCCTTGCCTTCGACGGGCTT
GCACACCAATGGCTATTCGTTGGCGCGAAAAGTTTGCGCACCCTTAGGCTATGCCAGCCAACCAACAATTTTAGCTGGTT
TGAGCATTGGCGAGGCTTTGCTGGCTCCGCATCGGGCCTATTTGCACGAAGTTCAGGCCTTGCGTCAAGCAGATGTGGCG
ATTCACGGTTTGGCCCATATCACTGGCGGCGGCATTTGGGATAACATTCCGCGGGTATTGCCAGCCAACGTGACAGTCGA
ATTAGTTCGTGGTTCATGGCAAGTTCCAGCAATTTTTAAATTAATTGTGGAACAAGCGGCGATGGATGAACACGAGGCCC
ATCATGTGCTCAATATGGGCTTGGGCATGATTCTATTTATTGCGGCTGAACAGGCTGAGCAAGCACTCGCAACCATCAGC
GATGCCCAACTGGTCGGACGGGTGATCGAGCAAATTAATCAACCGCGAGTGGTGCTAGTAGATCACTAG

Upstream 100 bases:

>100_bases
AACAATTATGCCGCTAACCAATAGCCCATCTTCGATCCTCAATGTTCTTTGTTCTATAATGAGCCATCAACCAATCAATT
CGGAACTGGAGTAGACAACC

Downstream 100 bases:

>100_bases
CAACTGTGCTATACTGCCATCGATAGTTTGCCAACCTTGGTATTAATTAAGGTTGGCAAACGAAAGCTAGTTGTCATCTT
CATCACTATCGCAACCAAAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTTYKDAGVDIATKMDAIQQMGAAVKATHTPAVLAGLGAFGGCFDLAQVNASHAQPVLVASTDGVGTKTAVAAAVGDVRT
IGADLVNHCINDILCQGATPLFFLDYIAASKLEPAMVVAAVEGLAAACRDAGIALLGGETAEMPGVYHDGAFDVAGTIVG
VVDRAHMLDGSAIKPGDVAIALPSTGLHTNGYSLARKVCAPLGYASQPTILAGLSIGEALLAPHRAYLHEVQALRQADVA
IHGLAHITGGGIWDNIPRVLPANVTVELVRGSWQVPAIFKLIVEQAAMDEHEAHHVLNMGLGMILFIAAEQAEQALATIS
DAQLVGRVIEQINQPRVVLVDH

Sequences:

>Translated_342_residues
MTTYKDAGVDIATKMDAIQQMGAAVKATHTPAVLAGLGAFGGCFDLAQVNASHAQPVLVASTDGVGTKTAVAAAVGDVRT
IGADLVNHCINDILCQGATPLFFLDYIAASKLEPAMVVAAVEGLAAACRDAGIALLGGETAEMPGVYHDGAFDVAGTIVG
VVDRAHMLDGSAIKPGDVAIALPSTGLHTNGYSLARKVCAPLGYASQPTILAGLSIGEALLAPHRAYLHEVQALRQADVA
IHGLAHITGGGIWDNIPRVLPANVTVELVRGSWQVPAIFKLIVEQAAMDEHEAHHVLNMGLGMILFIAAEQAEQALATIS
DAQLVGRVIEQINQPRVVLVDH
>Mature_341_residues
TTYKDAGVDIATKMDAIQQMGAAVKATHTPAVLAGLGAFGGCFDLAQVNASHAQPVLVASTDGVGTKTAVAAAVGDVRTI
GADLVNHCINDILCQGATPLFFLDYIAASKLEPAMVVAAVEGLAAACRDAGIALLGGETAEMPGVYHDGAFDVAGTIVGV
VDRAHMLDGSAIKPGDVAIALPSTGLHTNGYSLARKVCAPLGYASQPTILAGLSIGEALLAPHRAYLHEVQALRQADVAI
HGLAHITGGGIWDNIPRVLPANVTVELVRGSWQVPAIFKLIVEQAAMDEHEAHHVLNMGLGMILFIAAEQAEQALATISD
AQLVGRVIEQINQPRVVLVDH

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=42.3188405797101, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=42.3188405797101, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=42.3188405797101, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1788845, Length=341, Percent_Identity=43.6950146627566, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17567511, Length=324, Percent_Identity=36.1111111111111, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321203, Length=330, Percent_Identity=36.969696969697, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24582400, Length=299, Percent_Identity=32.7759197324415, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35338; Mature: 35207

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYKDAGVDIATKMDAIQQMGAAVKATHTPAVLAGLGAFGGCFDLAQVNASHAQPVLVA
CCCCCCCCCCHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEEE
STDGVGTKTAVAAAVGDVRTIGADLVNHCINDILCQGATPLFFLDYIAASKLEPAMVVAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
VEGLAAACRDAGIALLGGETAEMPGVYHDGAFDVAGTIVGVVDRAHMLDGSAIKPGDVAI
HHHHHHHHHHCCEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ALPSTGLHTNGYSLARKVCAPLGYASQPTILAGLSIGEALLAPHRAYLHEVQALRQADVA
EECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IHGLAHITGGGIWDNIPRVLPANVTVELVRGSWQVPAIFKLIVEQAAMDEHEAHHVLNMG
HHHHHHHCCCCHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LGMILFIAAEQAEQALATISDAQLVGRVIEQINQPRVVLVDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
TTYKDAGVDIATKMDAIQQMGAAVKATHTPAVLAGLGAFGGCFDLAQVNASHAQPVLVA
CCCCCCCCCHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEEE
STDGVGTKTAVAAAVGDVRTIGADLVNHCINDILCQGATPLFFLDYIAASKLEPAMVVAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
VEGLAAACRDAGIALLGGETAEMPGVYHDGAFDVAGTIVGVVDRAHMLDGSAIKPGDVAI
HHHHHHHHHHCCEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ALPSTGLHTNGYSLARKVCAPLGYASQPTILAGLSIGEALLAPHRAYLHEVQALRQADVA
EECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IHGLAHITGGGIWDNIPRVLPANVTVELVRGSWQVPAIFKLIVEQAAMDEHEAHHVLNMG
HHHHHHHCCCCHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LGMILFIAAEQAEQALATISDAQLVGRVIEQINQPRVVLVDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA