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The map label for this gene is coaBC [H]

Identifier: 159901337

GI number: 159901337

Start: 6152999

End: 6154201

Strand: Reverse

Name: coaBC [H]

Synonym: Haur_4826

Alternate gene names: 159901337

Gene position: 6154201-6152999 (Counterclockwise)

Preceding gene: 159901338

Following gene: 159901335

Centisome position: 96.97

GC content: 55.36

Gene sequence:

>1203_bases
ATGACTTTGGTTGATCGGCGAATTGTGCTGGGTGTGACGGGCGGAATTGCGGCCTATAAGGTCGTGCAGTTAGCACGCAA
TCTGAGCCTAGCTGGGGCGTTGGTCGATGTAGTGATGACTGAAGAGGCCACCAAATTCGTCACACCCTTGACCTTTGGCG
CATTAACCCATCGCCCAGTCTATACCGATATGTGGCAACTCTCCGAGCAAACCGATATTGGTCATGTAACAATTGGCGAT
CGCGCTGATCTGATCATCATCGCGCCTGCTACCGCCAACACGATTGCGCGGCTAGCCATGGGTATGAGCGATGATATGCT
GACCACCACCGTGCTGGCTTCGCGTGCGCCCATCTTGCTAGCTCCAGCGATGAATGTGAATATGTGGGCTAACCCCGCCA
CCCAAGCCAACATTGCAACCTTGCAAAGCCGTGGTTTCCAAATAATTCCCCCAACGGCGGGGCGCATGGCTGAGCCAATG
GTCGGGGTTGGACGACTAGCCGAGATCGATCAGATCGAAGCTGAGATTCGTTTGGCCTTGGGTCGGCGGTTTGGGGCATT
AGCTGGCAAGCGATTGATTATCACTGCTGGCGGCACTCACGAGGCGATCGATCCAGTACGCTTTATTGGCAATCGATCAT
CGGGCGTGATGGGCTTTGCGCTAGCTGCTGCCGCTCGTGATGCTGGCGCAGATGTGCGCTTGATTATCGGCGCAGCGAGT
GCCACGCCGCCGCTTGGCACGCAACACATCTACGCCGAAAGCGCTGCGGCCATGCACGATGCACTCCATCACGAAATTAG
CCAAGGCTGCGATCTGTTGATTATGGCCGCCGCAGTCGCCGATTATCGGCCTGTGAGCGTGGCCGATAATAAAATTAAAA
AAACTGAGCAAGCCGAACAAGCGCTGAGCTTGCAACTGACCCAAACCACCGATATTCTGGCCAGCCTCAAAGAGCATACT
GGCTTTGTAAAAATCGGCTTTGCTGCTGAAACTCACGATCTTGAGCAGTATGCCCAAGCCAAGCTCACGCGCAAAGGGCT
TGATGCGATTGTCGCCAACGATGCTCGCACCGCGCTCGGGGCCAGCGATAACGCCGTGACCGTGTTTCATCGCAACGGCC
AGCGCTGGGATTTTAACCGCCAAGCCAAAACCGAGCTGGCGCAGCAGTTGGTTGCGTTGTTCAGTGGTTTTTTAAGAACC
TAG

Upstream 100 bases:

>100_bases
ATGGCTCGGTACGCCATTGTTTAAATAATAGATTGAGATGCTGGTTACTGGTGTTTTAACTCAACCCAGCAACCAGCCTT
AGCTCATTGAGGGAGTTGCC

Downstream 100 bases:

>100_bases
AGCATAGAATATAGGGAGCAAGCGGGGGCGTTCAGTTTAACCACGAAGGACACGAAGCGCACAAAGAACGATTTAATAGT
TCTATGGCATCGATTAGTAA

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTLVDRRIVLGVTGGIAAYKVVQLARNLSLAGALVDVVMTEEATKFVTPLTFGALTHRPVYTDMWQLSEQTDIGHVTIGD
RADLIIIAPATANTIARLAMGMSDDMLTTTVLASRAPILLAPAMNVNMWANPATQANIATLQSRGFQIIPPTAGRMAEPM
VGVGRLAEIDQIEAEIRLALGRRFGALAGKRLIITAGGTHEAIDPVRFIGNRSSGVMGFALAAAARDAGADVRLIIGAAS
ATPPLGTQHIYAESAAAMHDALHHEISQGCDLLIMAAAVADYRPVSVADNKIKKTEQAEQALSLQLTQTTDILASLKEHT
GFVKIGFAAETHDLEQYAQAKLTRKGLDAIVANDARTALGASDNAVTVFHRNGQRWDFNRQAKTELAQQLVALFSGFLRT

Sequences:

>Translated_400_residues
MTLVDRRIVLGVTGGIAAYKVVQLARNLSLAGALVDVVMTEEATKFVTPLTFGALTHRPVYTDMWQLSEQTDIGHVTIGD
RADLIIIAPATANTIARLAMGMSDDMLTTTVLASRAPILLAPAMNVNMWANPATQANIATLQSRGFQIIPPTAGRMAEPM
VGVGRLAEIDQIEAEIRLALGRRFGALAGKRLIITAGGTHEAIDPVRFIGNRSSGVMGFALAAAARDAGADVRLIIGAAS
ATPPLGTQHIYAESAAAMHDALHHEISQGCDLLIMAAAVADYRPVSVADNKIKKTEQAEQALSLQLTQTTDILASLKEHT
GFVKIGFAAETHDLEQYAQAKLTRKGLDAIVANDARTALGASDNAVTVFHRNGQRWDFNRQAKTELAQQLVALFSGFLRT
>Mature_399_residues
TLVDRRIVLGVTGGIAAYKVVQLARNLSLAGALVDVVMTEEATKFVTPLTFGALTHRPVYTDMWQLSEQTDIGHVTIGDR
ADLIIIAPATANTIARLAMGMSDDMLTTTVLASRAPILLAPAMNVNMWANPATQANIATLQSRGFQIIPPTAGRMAEPMV
GVGRLAEIDQIEAEIRLALGRRFGALAGKRLIITAGGTHEAIDPVRFIGNRSSGVMGFALAAAARDAGADVRLIIGAASA
TPPLGTQHIYAESAAAMHDALHHEISQGCDLLIMAAAVADYRPVSVADNKIKKTEQAEQALSLQLTQTTDILASLKEHTG
FVKIGFAAETHDLEQYAQAKLTRKGLDAIVANDARTALGASDNAVTVFHRNGQRWDFNRQAKTELAQQLVALFSGFLRT

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=190, Percent_Identity=31.5789473684211, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI87082301, Length=381, Percent_Identity=41.2073490813648, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17560194, Length=180, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24657262, Length=178, Percent_Identity=32.0224719101124, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42636; Mature: 42504

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVDRRIVLGVTGGIAAYKVVQLARNLSLAGALVDVVMTEEATKFVTPLTFGALTHRPV
CCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCC
YTDMWQLSEQTDIGHVTIGDRADLIIIAPATANTIARLAMGMSDDMLTTTVLASRAPILL
HHHHHHHCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
APAMNVNMWANPATQANIATLQSRGFQIIPPTAGRMAEPMVGVGRLAEIDQIEAEIRLAL
ECCCCCEECCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GRRFGALAGKRLIITAGGTHEAIDPVRFIGNRSSGVMGFALAAAARDAGADVRLIIGAAS
HHHHHHCCCCEEEEEECCCCHHCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECC
ATPPLGTQHIYAESAAAMHDALHHEISQGCDLLIMAAAVADYRPVSVADNKIKKTEQAEQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHH
ALSLQLTQTTDILASLKEHTGFVKIGFAAETHDLEQYAQAKLTRKGLDAIVANDARTALG
HHEEEEHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEECCCHHHCC
ASDNAVTVFHRNGQRWDFNRQAKTELAQQLVALFSGFLRT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLVDRRIVLGVTGGIAAYKVVQLARNLSLAGALVDVVMTEEATKFVTPLTFGALTHRPV
CCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCC
YTDMWQLSEQTDIGHVTIGDRADLIIIAPATANTIARLAMGMSDDMLTTTVLASRAPILL
HHHHHHHCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
APAMNVNMWANPATQANIATLQSRGFQIIPPTAGRMAEPMVGVGRLAEIDQIEAEIRLAL
ECCCCCEECCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GRRFGALAGKRLIITAGGTHEAIDPVRFIGNRSSGVMGFALAAAARDAGADVRLIIGAAS
HHHHHHCCCCEEEEEECCCCHHCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECC
ATPPLGTQHIYAESAAAMHDALHHEISQGCDLLIMAAAVADYRPVSVADNKIKKTEQAEQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHH
ALSLQLTQTTDILASLKEHTGFVKIGFAAETHDLEQYAQAKLTRKGLDAIVANDARTALG
HHEEEEHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEECCCHHHCC
ASDNAVTVFHRNGQRWDFNRQAKTELAQQLVALFSGFLRT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]