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The map label for this gene is manC [H]

Identifier: 159901332

GI number: 159901332

Start: 6147774

End: 6148844

Strand: Direct

Name: manC [H]

Synonym: Haur_4821

Alternate gene names: 159901332

Gene position: 6147774-6148844 (Clockwise)

Preceding gene: 159901331

Following gene: 159901333

Centisome position: 96.87

GC content: 51.73

Gene sequence:

>1071_bases
ATGGATATTTTAGTGCTTGCTGGGGGTACTGGCTCGCGATTGTGGCCGCGTTCACGTCGCACCAAGCCCAAGCAATTTTT
ACCCTTGCTTTCAAATCGCACCATGCTGCAAGAAACCGTCGATCGGGTACGGCCTTTGATCGAAGAAGGTCGGGTGTTCG
TGGTGACTGGCTCGGATTACGAGGAATTAATTCGTGAGCAGTTGAACGACGTGCCGCGCAATAACGTTATTTTAGAGCCA
AGTGGCCGTGGCACAGCTTCGGCAATTGGCTTGGCGGCAATTCACATGCGTCGCTCGGCTCCCGATGCAGTGATGGCGGT
GCTGAGTGCTGATCATTTGATTTTGCGTAACGAAGCCTTTCGGCAAGCGCTACAAGCTGCCGAAGTTGCCGCCCGCGAAG
GCTATTTGGTCACACTTGGAGTTAAGCCATCGTTTGCCAATACGGGCTATGGCTATATTCAATGTGGCGAATTGATCACC
GAAGCGCATAATCATAAAATTCATCGGGTGCAGCGCTTTGCTGAAAAGCCCGACCACGATACCGCTGAGCGCTATCTCGC
CCAAGGCAATTATTTCTGGAACGCTGGGATTTTCGTTTGGCAAACCAAAACCTTCCTTGATGCGATTGGTCGCCACATGC
CCGAATTGCGCAACCAACTCAATCAAGTCCAAGCCTCGTTTGGCAAATCGCGCTACCACGATACATTGGCCCACGTCTGG
GAGAACGTCGAAAATATCACGGTCGATTATGGCATTATGGAGCGTGCACCAAATGTCGCGGTTGTGCCAGTTGATATTGG
CTGGAGCGACGTTGGCGATTGGCACACCCTGACAACCTTGATGAGCGACGACGATTCGGCCAATGTGGTAATTGGGCCAC
ACGTCGAGGTTGATACCAAATCGACCTTGATTTACAGCGATTCAGGCCGCATGATCGCTACGATTGGCCTTGATGGCTTT
TTGGTGGTCGATACTGGCGATGCCCTGTTGATTGCCCCCCGTGATCGCGCCCAAGATGTCAAGAAAATTGTTGATCAATT
GCGGACAGAAGGCCGCAATGATGTGTTATAA

Upstream 100 bases:

>100_bases
CGATACGCTGAGCGATATTCTGAATGAATGGCGCAGCCACGTTGCAACCGAGCAAGAGAGAGTTGGTTCCCACATTAACC
AATAACAGAGGATTAACCAT

Downstream 100 bases:

>100_bases
GTTATAATTGAAGGGCACGGCAGCAGGTGGTTAGCGATAACCAAACCACTGCCGTGCTTTTATGAAAGCAGTTGTATGCG
TGCAGTTATTTTAGTTGGCG

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDILVLAGGTGSRLWPRSRRTKPKQFLPLLSNRTMLQETVDRVRPLIEEGRVFVVTGSDYEELIREQLNDVPRNNVILEP
SGRGTASAIGLAAIHMRRSAPDAVMAVLSADHLILRNEAFRQALQAAEVAAREGYLVTLGVKPSFANTGYGYIQCGELIT
EAHNHKIHRVQRFAEKPDHDTAERYLAQGNYFWNAGIFVWQTKTFLDAIGRHMPELRNQLNQVQASFGKSRYHDTLAHVW
ENVENITVDYGIMERAPNVAVVPVDIGWSDVGDWHTLTTLMSDDDSANVVIGPHVEVDTKSTLIYSDSGRMIATIGLDGF
LVVDTGDALLIAPRDRAQDVKKIVDQLRTEGRNDVL

Sequences:

>Translated_356_residues
MDILVLAGGTGSRLWPRSRRTKPKQFLPLLSNRTMLQETVDRVRPLIEEGRVFVVTGSDYEELIREQLNDVPRNNVILEP
SGRGTASAIGLAAIHMRRSAPDAVMAVLSADHLILRNEAFRQALQAAEVAAREGYLVTLGVKPSFANTGYGYIQCGELIT
EAHNHKIHRVQRFAEKPDHDTAERYLAQGNYFWNAGIFVWQTKTFLDAIGRHMPELRNQLNQVQASFGKSRYHDTLAHVW
ENVENITVDYGIMERAPNVAVVPVDIGWSDVGDWHTLTTLMSDDDSANVVIGPHVEVDTKSTLIYSDSGRMIATIGLDGF
LVVDTGDALLIAPRDRAQDVKKIVDQLRTEGRNDVL
>Mature_356_residues
MDILVLAGGTGSRLWPRSRRTKPKQFLPLLSNRTMLQETVDRVRPLIEEGRVFVVTGSDYEELIREQLNDVPRNNVILEP
SGRGTASAIGLAAIHMRRSAPDAVMAVLSADHLILRNEAFRQALQAAEVAAREGYLVTLGVKPSFANTGYGYIQCGELIT
EAHNHKIHRVQRFAEKPDHDTAERYLAQGNYFWNAGIFVWQTKTFLDAIGRHMPELRNQLNQVQASFGKSRYHDTLAHVW
ENVENITVDYGIMERAPNVAVVPVDIGWSDVGDWHTLTTLMSDDDSANVVIGPHVEVDTKSTLIYSDSGRMIATIGLDGF
LVVDTGDALLIAPRDRAQDVKKIVDQLRTEGRNDVL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=356, Percent_Identity=38.2022471910112, Blast_Score=241, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 39720; Mature: 39720

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILVLAGGTGSRLWPRSRRTKPKQFLPLLSNRTMLQETVDRVRPLIEEGRVFVVTGSDY
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCH
EELIREQLNDVPRNNVILEPSGRGTASAIGLAAIHMRRSAPDAVMAVLSADHLILRNEAF
HHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHEEHHHHH
RQALQAAEVAAREGYLVTLGVKPSFANTGYGYIQCGELITEAHNHKIHRVQRFAEKPDHD
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHCCCCCH
TAERYLAQGNYFWNAGIFVWQTKTFLDAIGRHMPELRNQLNQVQASFGKSRYHDTLAHVW
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
ENVENITVDYGIMERAPNVAVVPVDIGWSDVGDWHTLTTLMSDDDSANVVIGPHVEVDTK
HCHHHEEEECHHHHCCCCEEEEEEECCCCCCCCHHHHHHEECCCCCCCEEECCCEEECCC
STLIYSDSGRMIATIGLDGFLVVDTGDALLIAPRDRAQDVKKIVDQLRTEGRNDVL
CEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDILVLAGGTGSRLWPRSRRTKPKQFLPLLSNRTMLQETVDRVRPLIEEGRVFVVTGSDY
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCH
EELIREQLNDVPRNNVILEPSGRGTASAIGLAAIHMRRSAPDAVMAVLSADHLILRNEAF
HHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHEEHHHHH
RQALQAAEVAAREGYLVTLGVKPSFANTGYGYIQCGELITEAHNHKIHRVQRFAEKPDHD
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHCCCCCH
TAERYLAQGNYFWNAGIFVWQTKTFLDAIGRHMPELRNQLNQVQASFGKSRYHDTLAHVW
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
ENVENITVDYGIMERAPNVAVVPVDIGWSDVGDWHTLTTLMSDDDSANVVIGPHVEVDTK
HCHHHEEEECHHHHCCCCEEEEEEECCCCCCCCHHHHHHEECCCCCCCEEECCCEEECCC
STLIYSDSGRMIATIGLDGFLVVDTGDALLIAPRDRAQDVKKIVDQLRTEGRNDVL
CEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]