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The map label for this gene is liaR [H]

Identifier: 159901290

GI number: 159901290

Start: 6094681

End: 6095307

Strand: Direct

Name: liaR [H]

Synonym: Haur_4778

Alternate gene names: 159901290

Gene position: 6094681-6095307 (Clockwise)

Preceding gene: 159901284

Following gene: 159901291

Centisome position: 96.03

GC content: 53.43

Gene sequence:

>627_bases
ATGATTCGAGTTGCAATTGTTGAAGATCAACGGATTGTTCGCGAAGGCTTGATTGCTGTTTTAGAGGATGAAGCGACGAT
TGAGATTGTGGGCGAGGCTGCTAACGGCCAAGCAGCCCTGGATTTGTATGCCCAAGAACTACCCGATGTCGTTTTGATGG
ATTTACAAATGCCCGTAATGGATGGCCCCACCGCGATTGGCCAACTCTGTCAGCGCTGGCCCCAAGCCAAAGTGCTGGTG
CTCACCACCTATGCGACTGATGAGTTTATTTGGGCGGCCTTGCGAGCTGGGGCCAAGGGTTATCTATTAAAGGATGCATC
GGCAGATGAATTGGTTTCGGCGATTCAGGCCGTTGCACGTGGTAGCACTCACCTTGCGCCGGATATTGCCGCCAAACTGG
TGGCTGGCGTGAGCAATCCCCAACCGGAATCGCTAACCCCGCGTGAGTTGGAAGTGCTGCACCTGCTGGGGCGTGGGCGC
TCCAATGGCGAAATTGCGCTTGAGTTGGATATTGCTTTGCGCACGGTTAAAGTGCATGTGCAAAATATCTTGGGCAAGCT
TGGGGCGACCAATCGCACCGAGGCTGTTAGTATCGCCGTGCGCCAACAATTAATCAGCCTTACATGA

Upstream 100 bases:

>100_bases
TAAGCGCCATTATAGCATAATCACGTCAAGCGAGACCCGTGTTAAGCTGATAGCTAGCTGATAGCAAGGCGCTAAAACCG
CCATCACCGAGGATGTTGCC

Downstream 100 bases:

>100_bases
TAGGGATGCAGGGTAATGTTTCAGATTGTCGTATTCATTCGTGGCTGGCTACCCCCAAGGATTAACCAACTTCTCACCAA
AACAGGACAATTAGCGGCGG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MIRVAIVEDQRIVREGLIAVLEDEATIEIVGEAANGQAALDLYAQELPDVVLMDLQMPVMDGPTAIGQLCQRWPQAKVLV
LTTYATDEFIWAALRAGAKGYLLKDASADELVSAIQAVARGSTHLAPDIAAKLVAGVSNPQPESLTPRELEVLHLLGRGR
SNGEIALELDIALRTVKVHVQNILGKLGATNRTEAVSIAVRQQLISLT

Sequences:

>Translated_208_residues
MIRVAIVEDQRIVREGLIAVLEDEATIEIVGEAANGQAALDLYAQELPDVVLMDLQMPVMDGPTAIGQLCQRWPQAKVLV
LTTYATDEFIWAALRAGAKGYLLKDASADELVSAIQAVARGSTHLAPDIAAKLVAGVSNPQPESLTPRELEVLHLLGRGR
SNGEIALELDIALRTVKVHVQNILGKLGATNRTEAVSIAVRQQLISLT
>Mature_208_residues
MIRVAIVEDQRIVREGLIAVLEDEATIEIVGEAANGQAALDLYAQELPDVVLMDLQMPVMDGPTAIGQLCQRWPQAKVLV
LTTYATDEFIWAALRAGAKGYLLKDASADELVSAIQAVARGSTHLAPDIAAKLVAGVSNPQPESLTPRELEVLHLLGRGR
SNGEIALELDIALRTVKVHVQNILGKLGATNRTEAVSIAVRQQLISLT

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=36.4077669902913, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788222, Length=213, Percent_Identity=32.8638497652582, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=36.9230769230769, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787473, Length=208, Percent_Identity=34.6153846153846, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=26.8292682926829, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788546, Length=212, Percent_Identity=27.8301886792453, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=35.5769230769231, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788550, Length=114, Percent_Identity=37.719298245614, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788712, Length=181, Percent_Identity=23.7569060773481, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22315; Mature: 22315

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAIVEDQRIVREGLIAVLEDEATIEIVGEAANGQAALDLYAQELPDVVLMDLQMPVM
CEEEEEECCHHHHHHHHHEEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCC
DGPTAIGQLCQRWPQAKVLVLTTYATDEFIWAALRAGAKGYLLKDASADELVSAIQAVAR
CCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHC
GSTHLAPDIAAKLVAGVSNPQPESLTPRELEVLHLLGRGRSNGEIALELDIALRTVKVHV
CCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHH
QNILGKLGATNRTEAVSIAVRQQLISLT
HHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRVAIVEDQRIVREGLIAVLEDEATIEIVGEAANGQAALDLYAQELPDVVLMDLQMPVM
CEEEEEECCHHHHHHHHHEEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCC
DGPTAIGQLCQRWPQAKVLVLTTYATDEFIWAALRAGAKGYLLKDASADELVSAIQAVAR
CCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHC
GSTHLAPDIAAKLVAGVSNPQPESLTPRELEVLHLLGRGRSNGEIALELDIALRTVKVHV
CCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHH
QNILGKLGATNRTEAVSIAVRQQLISLT
HHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]