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The map label for this gene is kinB [H]

Identifier: 159901168

GI number: 159901168

Start: 5947907

End: 5949940

Strand: Direct

Name: kinB [H]

Synonym: Haur_4656

Alternate gene names: 159901168

Gene position: 5947907-5949940 (Clockwise)

Preceding gene: 159901167

Following gene: 159901169

Centisome position: 93.72

GC content: 49.95

Gene sequence:

>2034_bases
ATGGCTGACGTTGCAACTACCCAAAATCACGCACGTCCAATCAGCGGTTTTCAGTTGTTGGCAATTGCCGAGGCAATCAA
CAACGCAGCAAATCTTAGTTCTTTGGTAGCTACAGTGGCCGAGTTATGTGCTACTGGTTTTGGGGTCGAAGTCGTTAAGT
TGGGGCTGCTTGATAACGAACACCATAGCGGTTCGTCCACGCCATATCTCTATGGCAACCCCAGCAAAGCCACCCAAAAA
TTGCTCGATCAAGCGATTGCCCAAACCATCGAACAAAAAACTGCCCTGTTGCCAAGCAATGACGAGAGTGCCCAAGCCCA
ATTGTTGGTGTTGCCGTTATTGGCCAGCCAGCAATTAATTGGCTTTTTGGCCTTGCTCTTGCCCAAAAAAGGCCGTTGGT
CGGCTGAAGCAATCGAGGCTGCTCAGTTGTTGGCGCATAATTTGGCTCTAGCGATTTCAGCGGTTCAGCTTAAAGACTAT
ACCGCTAAACGTAATCAAGAAATTAATACGCTCAACGATATCGCCGCCACAATCACTTCATCGCTTGATCCACGCCAAGT
CTATCGCTTGGTGGTCAAGAAGATCAACGAATATTTTCAGGTTGAGGCTGGTTCACTGCTACTGCTCGATCCCGTGACCA
ACGAATTGGTCTTTGTGATGACGCTTGAGGCGGGCGAAGAAAAATTGGCGGGCGTGCGGGTTCCACCTGGCCAAGGTTTG
GTTGGGGCAGCAATTACCACCCGCCAGCCAGTCGTCGTGCTCGATGCCCAAAACGACCCACGTTTCTATCGGCGGGTTAG
CGAGGATGTTGGATTTGTGACGCGCTCGGTCTTGTGCGTGCCCATGCTGGTGAAAAATCGTGAAATTGGGGTGATTCAGT
TGTTGAATAAGCTAGAAGGCGTATTTAACACTGAAGATACCCAACGCCTGCAAGCTATGGCTAACACGGTGGGCGTGGCG
ATCGATAACGCTAATCTGTTTCACGAAGTTTCGCAAAACCGCAATCGCCTCCAAGCCTTGCTCAACTCCACCACCGACGG
TATTTTGATGATCGACCCTGATGATGTGGTGTTGACTGCTAATCCAATGCTGGGTGAGTTGTTTGGCTGGGAATGGCGCA
ATATCATCGGCGAGGCTGGCAGCGATATTCTGGCTCGCATCAAAGAGCAATCGCGGGTGGTCAACGAGTTGCCCAATAGC
GAAACCTGCGAAATTGAAGTGTTGCGGCCTCGTACCCGCTATGTGCGCCAAGAGCCATTGCCAGTGCGCAATAATTTTGG
CAATGTGATTGGCACGCTGATTGTGTTCCACGATATTACCGAGGAATATCAGCTAGCCCAAATTCGCGAAGATTATATGG
GCATGTTGGTGCACGATTTGCGTGCGCCACTCACGGCGATCATCAATGGTATGACCATGGTGCGCCGTGGTTTTGCTGGC
CCAATTAACGACCAGCAACGCGAATTGCTAGATATTGCCAACAATAGCAGCCAAGAAATGGTTGGCATGATCAATACCTT
GCTGGATATTAGCAAGATGGAAGCTGGCGAATTGGTGCTGAATCGTGCGCCATGCTCAGCCTACGAAATTGTTGATCGTG
CTTCGGAACGTTTGATTAACTCAGCTCGCAGCGTTGATATCAGCATCAATCTGGATATGGCCCTGAATTTGCCAATTATC
GATGCTGACCAAGATAAAATTGTGCGGATCTTGCAAAACCTGCTGGATAACGCGATCAAATTTACGCCAGTTGGCGGAAG
TGTTACAATCCGCGTGCGCCAATTAACTGATAATGAAAAGCAGACGATCTGCTGGAGTGTAATTGATGCCGGACCGGGCA
TTCCCGAAAGCTATCGTGCCAAGATTTTCGATAAGTTTGTGCAGGTTGCTGGCCAGAGAAAAGGCACGGGCTTGGGCCTG
GCCTTTGCCAAACTTGCATCAGAAGCCCACGGCGGGCGGATTTGGGTTGAAAGTGTTGAGGGCGAAGGTAGTACATTCTC
GTTTACCATTCCGTATGAGCCAGCAGTGAAATAG

Upstream 100 bases:

>100_bases
GGAGCTAAGTTTGTTGGTAAAACTCCTTGCGTTTGGGGCATGCTCTACAGTATAATTTTCCTCAGAGAAGCCTGAAATCT
ACGATTTGAGCACAATACAT

Downstream 100 bases:

>100_bases
CCTTCTATGTTTGTCAACCTGCGGCGACGGCTAAAAAGTCGCATTCGGTATAAAATCACCCTGCCATATTTGCTCTTGCT
AGCATTTTTGTCGGGCTTAT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MADVATTQNHARPISGFQLLAIAEAINNAANLSSLVATVAELCATGFGVEVVKLGLLDNEHHSGSSTPYLYGNPSKATQK
LLDQAIAQTIEQKTALLPSNDESAQAQLLVLPLLASQQLIGFLALLLPKKGRWSAEAIEAAQLLAHNLALAISAVQLKDY
TAKRNQEINTLNDIAATITSSLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELVFVMTLEAGEEKLAGVRVPPGQGL
VGAAITTRQPVVVLDAQNDPRFYRRVSEDVGFVTRSVLCVPMLVKNREIGVIQLLNKLEGVFNTEDTQRLQAMANTVGVA
IDNANLFHEVSQNRNRLQALLNSTTDGILMIDPDDVVLTANPMLGELFGWEWRNIIGEAGSDILARIKEQSRVVNELPNS
ETCEIEVLRPRTRYVRQEPLPVRNNFGNVIGTLIVFHDITEEYQLAQIREDYMGMLVHDLRAPLTAIINGMTMVRRGFAG
PINDQQRELLDIANNSSQEMVGMINTLLDISKMEAGELVLNRAPCSAYEIVDRASERLINSARSVDISINLDMALNLPII
DADQDKIVRILQNLLDNAIKFTPVGGSVTIRVRQLTDNEKQTICWSVIDAGPGIPESYRAKIFDKFVQVAGQRKGTGLGL
AFAKLASEAHGGRIWVESVEGEGSTFSFTIPYEPAVK

Sequences:

>Translated_677_residues
MADVATTQNHARPISGFQLLAIAEAINNAANLSSLVATVAELCATGFGVEVVKLGLLDNEHHSGSSTPYLYGNPSKATQK
LLDQAIAQTIEQKTALLPSNDESAQAQLLVLPLLASQQLIGFLALLLPKKGRWSAEAIEAAQLLAHNLALAISAVQLKDY
TAKRNQEINTLNDIAATITSSLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELVFVMTLEAGEEKLAGVRVPPGQGL
VGAAITTRQPVVVLDAQNDPRFYRRVSEDVGFVTRSVLCVPMLVKNREIGVIQLLNKLEGVFNTEDTQRLQAMANTVGVA
IDNANLFHEVSQNRNRLQALLNSTTDGILMIDPDDVVLTANPMLGELFGWEWRNIIGEAGSDILARIKEQSRVVNELPNS
ETCEIEVLRPRTRYVRQEPLPVRNNFGNVIGTLIVFHDITEEYQLAQIREDYMGMLVHDLRAPLTAIINGMTMVRRGFAG
PINDQQRELLDIANNSSQEMVGMINTLLDISKMEAGELVLNRAPCSAYEIVDRASERLINSARSVDISINLDMALNLPII
DADQDKIVRILQNLLDNAIKFTPVGGSVTIRVRQLTDNEKQTICWSVIDAGPGIPESYRAKIFDKFVQVAGQRKGTGLGL
AFAKLASEAHGGRIWVESVEGEGSTFSFTIPYEPAVK
>Mature_676_residues
ADVATTQNHARPISGFQLLAIAEAINNAANLSSLVATVAELCATGFGVEVVKLGLLDNEHHSGSSTPYLYGNPSKATQKL
LDQAIAQTIEQKTALLPSNDESAQAQLLVLPLLASQQLIGFLALLLPKKGRWSAEAIEAAQLLAHNLALAISAVQLKDYT
AKRNQEINTLNDIAATITSSLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELVFVMTLEAGEEKLAGVRVPPGQGLV
GAAITTRQPVVVLDAQNDPRFYRRVSEDVGFVTRSVLCVPMLVKNREIGVIQLLNKLEGVFNTEDTQRLQAMANTVGVAI
DNANLFHEVSQNRNRLQALLNSTTDGILMIDPDDVVLTANPMLGELFGWEWRNIIGEAGSDILARIKEQSRVVNELPNSE
TCEIEVLRPRTRYVRQEPLPVRNNFGNVIGTLIVFHDITEEYQLAQIREDYMGMLVHDLRAPLTAIINGMTMVRRGFAGP
INDQQRELLDIANNSSQEMVGMINTLLDISKMEAGELVLNRAPCSAYEIVDRASERLINSARSVDISINLDMALNLPIID
ADQDKIVRILQNLLDNAIKFTPVGGSVTIRVRQLTDNEKQTICWSVIDAGPGIPESYRAKIFDKFVQVAGQRKGTGLGLA
FAKLASEAHGGRIWVESVEGEGSTFSFTIPYEPAVK

Specific function: Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. KinB functions as a membrane-associated protein kinase that phosphorylates AlgB, probably in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Homo sapiens, GI5729972, Length=248, Percent_Identity=26.2096774193548, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI194595488, Length=248, Percent_Identity=26.2096774193548, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI4505657, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI226246591, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI219802706, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI116536085, Length=155, Percent_Identity=32.9032258064516, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788549, Length=366, Percent_Identity=28.1420765027322, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=30.8695652173913, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=29.5546558704453, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI48994928, Length=368, Percent_Identity=27.1739130434783, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=28.0334728033473, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=26.4069264069264, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=28.1512605042017, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=29.6137339055794, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=29.6610169491525, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=25.2066115702479, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=30.4545454545455, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=27.5229357798165, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193202333, Length=196, Percent_Identity=25, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013656
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF08448 PAS_4 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74169; Mature: 74038

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVATTQNHARPISGFQLLAIAEAINNAANLSSLVATVAELCATGFGVEVVKLGLLDNE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
HHSGSSTPYLYGNPSKATQKLLDQAIAQTIEQKTALLPSNDESAQAQLLVLPLLASQQLI
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHH
GFLALLLPKKGRWSAEAIEAAQLLAHNLALAISAVQLKDYTAKRNQEINTLNDIAATITS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELVFVMTLEAGEEKLAGVRVPPGQGL
CCCHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCEEEEEEECCCCHHHCCEECCCCCCC
VGAAITTRQPVVVLDAQNDPRFYRRVSEDVGFVTRSVLCVPMLVKNREIGVIQLLNKLEG
EEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VFNTEDTQRLQAMANTVGVAIDNANLFHEVSQNRNRLQALLNSTTDGILMIDPDDVVLTA
CCCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEC
NPMLGELFGWEWRNIIGEAGSDILARIKEQSRVVNELPNSETCEIEVLRPRTRYVRQEPL
CCHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCC
PVRNNFGNVIGTLIVFHDITEEYQLAQIREDYMGMLVHDLRAPLTAIINGMTMVRRGFAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PINDQQRELLDIANNSSQEMVGMINTLLDISKMEAGELVLNRAPCSAYEIVDRASERLIN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SARSVDISINLDMALNLPIIDADQDKIVRILQNLLDNAIKFTPVGGSVTIRVRQLTDNEK
HHCEEEEEEEEEEEECCCEEECCHHHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCCCC
QTICWSVIDAGPGIPESYRAKIFDKFVQVAGQRKGTGLGLAFAKLASEAHGGRIWVESVE
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
GEGSTFSFTIPYEPAVK
CCCCEEEEECCCCCCCC
>Mature Secondary Structure 
ADVATTQNHARPISGFQLLAIAEAINNAANLSSLVATVAELCATGFGVEVVKLGLLDNE
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
HHSGSSTPYLYGNPSKATQKLLDQAIAQTIEQKTALLPSNDESAQAQLLVLPLLASQQLI
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHH
GFLALLLPKKGRWSAEAIEAAQLLAHNLALAISAVQLKDYTAKRNQEINTLNDIAATITS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELVFVMTLEAGEEKLAGVRVPPGQGL
CCCHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCEEEEEEECCCCHHHCCEECCCCCCC
VGAAITTRQPVVVLDAQNDPRFYRRVSEDVGFVTRSVLCVPMLVKNREIGVIQLLNKLEG
EEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VFNTEDTQRLQAMANTVGVAIDNANLFHEVSQNRNRLQALLNSTTDGILMIDPDDVVLTA
CCCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEC
NPMLGELFGWEWRNIIGEAGSDILARIKEQSRVVNELPNSETCEIEVLRPRTRYVRQEPL
CCHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCC
PVRNNFGNVIGTLIVFHDITEEYQLAQIREDYMGMLVHDLRAPLTAIINGMTMVRRGFAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PINDQQRELLDIANNSSQEMVGMINTLLDISKMEAGELVLNRAPCSAYEIVDRASERLIN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SARSVDISINLDMALNLPIIDADQDKIVRILQNLLDNAIKFTPVGGSVTIRVRQLTDNEK
HHCEEEEEEEEEEEECCCEEECCHHHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCCCC
QTICWSVIDAGPGIPESYRAKIFDKFVQVAGQRKGTGLGLAFAKLASEAHGGRIWVESVE
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
GEGSTFSFTIPYEPAVK
CCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9218420 [H]