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The map label for this gene is gppA [H]

Identifier: 159901129

GI number: 159901129

Start: 5902810

End: 5904318

Strand: Reverse

Name: gppA [H]

Synonym: Haur_4617

Alternate gene names: 159901129

Gene position: 5904318-5902810 (Counterclockwise)

Preceding gene: 159901130

Following gene: 159901114

Centisome position: 93.03

GC content: 50.1

Gene sequence:

>1509_bases
ATGACCCAACACGTTGGAATTATTGACCTTGGCTCCAACACCGCCCGCATGATCGTGGTGCAATACCAGCCCTATTACTC
CTTCAAACTGGTCGAAGAAGTTAAAGAAAATGTGCGCTTGGCACATAATGTTGGCGCTGATAATCAATTGCAAGCTGAGC
CGATGGCCATGGCAATTGAAACCTTGCGCATGTTTAGCAATTTTTGCCGTGCCTTGGGGGTTAATGAAGTTGTGGCTGTG
GCCACCAGCGCCGTGCGCGATGCCGCCAATCAAGCCAGCTTTTTGGCCCAAGTTAAAGAAGAAACTGGCCTCGATTTACG
CGTACTCAGCGGCGATGAAGAAGCCTACTACAGCTACCTCGGGGTGATTAATACCCTTGGGGTCAGCAATGGTTTTATGT
TTGATATTGGCGGTGGCAGCGTCGAATTGGCCTTAGTTCGAGGCCGGGGCTTGGCGCATACCACTTCATTACCACTTGGT
ACAGTGCGGCTCACCGAGCAAATTTTGCGCAGCGAAACCCCCAGCAAAGCCGAACTCAAAGCCCTCGATCGCCATTTAGA
TGAGGCGTTAGCCGAACTAGACTGGTTTCGACCACAAGGTAGCAAATTGCCGTTAATTGGGGTTGGCGGCACGGTGCGCA
ACCTTGCCAAACTCGAACAACGTGCCCAGCGCTATCCACTCGATATTGTGCATGGCTATACGATGTCGTTGCAACGGGTC
GATGAATGGGCTACCCGTTTGAGCAAACTCAATCGTAATGAGCGCGAGCAGCTTGATGGCCTCAACAATGATCGCGCCGA
TGTTATTACCGCTGGTGTACTGTTGATTCGAGCGTTGATGCAACGTTGTGGTGCTGATAGTTTGTGGATTTGTGGTCATG
GTCTGCGTGATGGTATCTTCTACGAGCAATTTCTGCGTGGCTCACAACCGCCCTTGCTCGGCGATGTCCGCCAGTTTTCG
GTCGAGAATTTGGCACGAATCTATGGCTACAATGTGGTACATGTTGCCAAAGTGCGCGAATTAAGCCTCGCCTTGTTTGA
TCAACTGCAAAGTTTGCATGGCTATGGAGCGTGGGAACGCGAATTACTCGAAGCTGCGACGGTAGTCCATGACATTGGGG
TAGCAGTCAATTTCTACGATCATCATAAACATGGCTTATATTTAATTCTCAACTCAATGCTGAATGGCTATACCCACCGC
GAAATGGCCATGGTAGCCTTGCTCACTCGCCATCATCGTAAGGGCGGCGTGACTGATGCAGGCTTGGGTGGGGTTTTGGC
TGAGGGTGATCTTGAGCGGGTGGGCAAATTAAGTGCCTTGCTCAGAATAGCTGAATATCTAGAGCGCTCCAAGAGCCAAG
TTGTGCAAAGTATCGTGTGCAAAATTGAGAAAAATCAGGTGCGGGTGAAGGTGCAGGCGGTTGGCGACGCTTCGATTGAA
ATTTGGGATGCGAATCGCAAAACCAATCTATTTCGCAAAGTCTATGGAGTTGAAATGTTGATTGAATAG

Upstream 100 bases:

>100_bases
CCTGGCTCTACAATTGGGCTGGTGTCGGCACAACCGTCCAAGTATATTACTAAAATTTATGCTGGCGGGCGGCCTGCTAC
ACGTTGTTGAGGAGAATGAT

Downstream 100 bases:

>100_bases
CCCTAGCAAGCTTGGGGTTTTGCTAGGGCTATACCTTAGAAAATAGCAGGAACAACTGCTAATTGATCGCCGAGTTGGGT
TTGGGATTGTTGAATAACCC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTQHVGIIDLGSNTARMIVVQYQPYYSFKLVEEVKENVRLAHNVGADNQLQAEPMAMAIETLRMFSNFCRALGVNEVVAV
ATSAVRDAANQASFLAQVKEETGLDLRVLSGDEEAYYSYLGVINTLGVSNGFMFDIGGGSVELALVRGRGLAHTTSLPLG
TVRLTEQILRSETPSKAELKALDRHLDEALAELDWFRPQGSKLPLIGVGGTVRNLAKLEQRAQRYPLDIVHGYTMSLQRV
DEWATRLSKLNRNEREQLDGLNNDRADVITAGVLLIRALMQRCGADSLWICGHGLRDGIFYEQFLRGSQPPLLGDVRQFS
VENLARIYGYNVVHVAKVRELSLALFDQLQSLHGYGAWERELLEAATVVHDIGVAVNFYDHHKHGLYLILNSMLNGYTHR
EMAMVALLTRHHRKGGVTDAGLGGVLAEGDLERVGKLSALLRIAEYLERSKSQVVQSIVCKIEKNQVRVKVQAVGDASIE
IWDANRKTNLFRKVYGVEMLIE

Sequences:

>Translated_502_residues
MTQHVGIIDLGSNTARMIVVQYQPYYSFKLVEEVKENVRLAHNVGADNQLQAEPMAMAIETLRMFSNFCRALGVNEVVAV
ATSAVRDAANQASFLAQVKEETGLDLRVLSGDEEAYYSYLGVINTLGVSNGFMFDIGGGSVELALVRGRGLAHTTSLPLG
TVRLTEQILRSETPSKAELKALDRHLDEALAELDWFRPQGSKLPLIGVGGTVRNLAKLEQRAQRYPLDIVHGYTMSLQRV
DEWATRLSKLNRNEREQLDGLNNDRADVITAGVLLIRALMQRCGADSLWICGHGLRDGIFYEQFLRGSQPPLLGDVRQFS
VENLARIYGYNVVHVAKVRELSLALFDQLQSLHGYGAWERELLEAATVVHDIGVAVNFYDHHKHGLYLILNSMLNGYTHR
EMAMVALLTRHHRKGGVTDAGLGGVLAEGDLERVGKLSALLRIAEYLERSKSQVVQSIVCKIEKNQVRVKVQAVGDASIE
IWDANRKTNLFRKVYGVEMLIE
>Mature_501_residues
TQHVGIIDLGSNTARMIVVQYQPYYSFKLVEEVKENVRLAHNVGADNQLQAEPMAMAIETLRMFSNFCRALGVNEVVAVA
TSAVRDAANQASFLAQVKEETGLDLRVLSGDEEAYYSYLGVINTLGVSNGFMFDIGGGSVELALVRGRGLAHTTSLPLGT
VRLTEQILRSETPSKAELKALDRHLDEALAELDWFRPQGSKLPLIGVGGTVRNLAKLEQRAQRYPLDIVHGYTMSLQRVD
EWATRLSKLNRNEREQLDGLNNDRADVITAGVLLIRALMQRCGADSLWICGHGLRDGIFYEQFLRGSQPPLLGDVRQFSV
ENLARIYGYNVVHVAKVRELSLALFDQLQSLHGYGAWERELLEAATVVHDIGVAVNFYDHHKHGLYLILNSMLNGYTHRE
MAMVALLTRHHRKGGVTDAGLGGVLAEGDLERVGKLSALLRIAEYLERSKSQVVQSIVCKIEKNQVRVKVQAVGDASIEI
WDANRKTNLFRKVYGVEMLIE

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=405, Percent_Identity=27.9012345679012, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788848, Length=427, Percent_Identity=25.5269320843091, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55850; Mature: 55719

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHVGIIDLGSNTARMIVVQYQPYYSFKLVEEVKENVRLAHNVGADNQLQAEPMAMAIE
CCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TLRMFSNFCRALGVNEVVAVATSAVRDAANQASFLAQVKEETGLDLRVLSGDEEAYYSYL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
GVINTLGVSNGFMFDIGGGSVELALVRGRGLAHTTSLPLGTVRLTEQILRSETPSKAELK
HHHHHCCCCCCEEEEECCCEEEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHH
ALDRHLDEALAELDWFRPQGSKLPLIGVGGTVRNLAKLEQRAQRYPLDIVHGYTMSLQRV
HHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
DEWATRLSKLNRNEREQLDGLNNDRADVITAGVLLIRALMQRCGADSLWICGHGLRDGIF
HHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHH
YEQFLRGSQPPLLGDVRQFSVENLARIYGYNVVHVAKVRELSLALFDQLQSLHGYGAWER
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHH
ELLEAATVVHDIGVAVNFYDHHKHGLYLILNSMLNGYTHREMAMVALLTRHHRKGGVTDA
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
GLGGVLAEGDLERVGKLSALLRIAEYLERSKSQVVQSIVCKIEKNQVRVKVQAVGDASIE
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEEEECCCEEE
IWDANRKTNLFRKVYGVEMLIE
EEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQHVGIIDLGSNTARMIVVQYQPYYSFKLVEEVKENVRLAHNVGADNQLQAEPMAMAIE
CCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TLRMFSNFCRALGVNEVVAVATSAVRDAANQASFLAQVKEETGLDLRVLSGDEEAYYSYL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
GVINTLGVSNGFMFDIGGGSVELALVRGRGLAHTTSLPLGTVRLTEQILRSETPSKAELK
HHHHHCCCCCCEEEEECCCEEEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHH
ALDRHLDEALAELDWFRPQGSKLPLIGVGGTVRNLAKLEQRAQRYPLDIVHGYTMSLQRV
HHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
DEWATRLSKLNRNEREQLDGLNNDRADVITAGVLLIRALMQRCGADSLWICGHGLRDGIF
HHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHH
YEQFLRGSQPPLLGDVRQFSVENLARIYGYNVVHVAKVRELSLALFDQLQSLHGYGAWER
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHH
ELLEAATVVHDIGVAVNFYDHHKHGLYLILNSMLNGYTHREMAMVALLTRHHRKGGVTDA
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
GLGGVLAEGDLERVGKLSALLRIAEYLERSKSQVVQSIVCKIEKNQVRVKVQAVGDASIE
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEEEECCCEEE
IWDANRKTNLFRKVYGVEMLIE
EEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA