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The map label for this gene is hisN [H]

Identifier: 159901048

GI number: 159901048

Start: 5805535

End: 5806326

Strand: Reverse

Name: hisN [H]

Synonym: Haur_4536

Alternate gene names: 159901048

Gene position: 5806326-5805535 (Counterclockwise)

Preceding gene: 159901049

Following gene: 159901047

Centisome position: 91.49

GC content: 51.77

Gene sequence:

>792_bases
ATGCAATCACCCAACGAAGCTCAATTGATGGAAACTTGGGCACGCCAAGCAGGAGCCTATGCCCTCGATATTTTTCATGA
TTACAATGCAGCCGCGCCACGCCGCAAAGCTGATAACTCGTGGGTAACCGAGGTTGATGAAACAATTGAACAGATGCTGC
GCCAACACATTGCTCAAGCCTTTCCCGATGATCTGATTATGGGCGAAGAGGGCGGCGGCCAAGCCAGCAACAGCGGGCGG
ATTTGGGTGCTTGATCCAATTGATGGCACTGGTTCGTTTGTTAAGCGTTTGCCAGTGTGGTGCGTTTCGATTGGCTTGTT
GGTCGATGGCTATCCAGCGGCTGGCTGCGTGTATTTGCCAGTGCTCGATGAATGTTATTTGGCGGGATTAACTGGTGATG
CAACCCTCAACGGCCAAATCATCAACGCCGAAAACCCAGATTTTCTCGATAGCCAATCGTGGATGGCTGTGCCATCGAAT
GCCCATCGTCGCTACAAAATTAGCTATCCAGGTAAAACTCGCTCACTTGGCAGCACGGCCGCCAATGTTTGCTATGTGGC
TAGTAGCCGCGCGTGTGCCGCAATTTTGGGCAACGCCAGCTTGTGGGATATTGCCGGAGCATGGCCAATTTTAGAGCGGG
CTGGTGGTAAGCTATCAACATTTTCGGGCGGGCCATTCGATTGGCAGCGTTTTTACCAAGGCGCATCGGCCAACGAGCCA
TTATTTGCTGCCAGCAACAACAATTATGCCAATATGCGGGCAATGATCGACTTGGCTCAAGGCGCAATTTAA

Upstream 100 bases:

>100_bases
AGACGACGAATAATTCAATCTGTGACGACGAAGCCACTCACCGTGACCAGCATTGTGCTGATCGCGGTAGCTTTGTTGGT
CGCGAATAAAGGATACAACA

Downstream 100 bases:

>100_bases
TCAGCAGCTTTGATCGCACCATGGTATCATAGGCCAGATTAAAGCCACCTCAGCGAAGGAACCAACTGATGGCTGATGTA
ACTCAGTTTGTGCGGCCTGA

Product: inositol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQSPNEAQLMETWARQAGAYALDIFHDYNAAAPRRKADNSWVTEVDETIEQMLRQHIAQAFPDDLIMGEEGGGQASNSGR
IWVLDPIDGTGSFVKRLPVWCVSIGLLVDGYPAAGCVYLPVLDECYLAGLTGDATLNGQIINAENPDFLDSQSWMAVPSN
AHRRYKISYPGKTRSLGSTAANVCYVASSRACAAILGNASLWDIAGAWPILERAGGKLSTFSGGPFDWQRFYQGASANEP
LFAASNNNYANMRAMIDLAQGAI

Sequences:

>Translated_263_residues
MQSPNEAQLMETWARQAGAYALDIFHDYNAAAPRRKADNSWVTEVDETIEQMLRQHIAQAFPDDLIMGEEGGGQASNSGR
IWVLDPIDGTGSFVKRLPVWCVSIGLLVDGYPAAGCVYLPVLDECYLAGLTGDATLNGQIINAENPDFLDSQSWMAVPSN
AHRRYKISYPGKTRSLGSTAANVCYVASSRACAAILGNASLWDIAGAWPILERAGGKLSTFSGGPFDWQRFYQGASANEP
LFAASNNNYANMRAMIDLAQGAI
>Mature_263_residues
MQSPNEAQLMETWARQAGAYALDIFHDYNAAAPRRKADNSWVTEVDETIEQMLRQHIAQAFPDDLIMGEEGGGQASNSGR
IWVLDPIDGTGSFVKRLPVWCVSIGLLVDGYPAAGCVYLPVLDECYLAGLTGDATLNGQIINAENPDFLDSQSWMAVPSN
AHRRYKISYPGKTRSLGSTAANVCYVASSRACAAILGNASLWDIAGAWPILERAGGKLSTFSGGPFDWQRFYQGASANEP
LFAASNNNYANMRAMIDLAQGAI

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=234, Percent_Identity=34.1880341880342, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI221625487, Length=234, Percent_Identity=34.1880341880342, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI7657236, Length=203, Percent_Identity=29.064039408867, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788882, Length=222, Percent_Identity=30.1801801801802, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790659, Length=228, Percent_Identity=28.5087719298246, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=234, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193202572, Length=232, Percent_Identity=29.3103448275862, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320493, Length=197, Percent_Identity=32.48730964467, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664926, Length=271, Percent_Identity=30.6273062730627, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24664922, Length=215, Percent_Identity=33.0232558139535, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21357329, Length=208, Percent_Identity=29.3269230769231, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357957, Length=206, Percent_Identity=29.126213592233, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24664918, Length=206, Percent_Identity=29.6116504854369, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357303, Length=234, Percent_Identity=28.2051282051282, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28434; Mature: 28434

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSPNEAQLMETWARQAGAYALDIFHDYNAAAPRRKADNSWVTEVDETIEQMLRQHIAQA
CCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FPDDLIMGEEGGGQASNSGRIWVLDPIDGTGSFVKRLPVWCVSIGLLVDGYPAAGCVYLP
CCCCEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
VLDECYLAGLTGDATLNGQIINAENPDFLDSQSWMAVPSNAHRRYKISYPGKTRSLGSTA
EHHHHHHCCCCCCCEECCEEECCCCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCHH
ANVCYVASSRACAAILGNASLWDIAGAWPILERAGGKLSTFSGGPFDWQRFYQGASANEP
HHEEEEECCCCEEHHHCCCCEECCCCCCHHHHHCCCCEEECCCCCCCHHHHHCCCCCCCC
LFAASNNNYANMRAMIDLAQGAI
EEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSPNEAQLMETWARQAGAYALDIFHDYNAAAPRRKADNSWVTEVDETIEQMLRQHIAQA
CCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FPDDLIMGEEGGGQASNSGRIWVLDPIDGTGSFVKRLPVWCVSIGLLVDGYPAAGCVYLP
CCCCEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
VLDECYLAGLTGDATLNGQIINAENPDFLDSQSWMAVPSNAHRRYKISYPGKTRSLGSTA
EHHHHHHCCCCCCCEECCEEECCCCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCHH
ANVCYVASSRACAAILGNASLWDIAGAWPILERAGGKLSTFSGGPFDWQRFYQGASANEP
HHEEEEECCCCEEHHHCCCCEECCCCCCHHHHHCCCCEEECCCCCCCHHHHHCCCCCCCC
LFAASNNNYANMRAMIDLAQGAI
EEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]