Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 159900906

GI number: 159900906

Start: 5612218

End: 5613396

Strand: Reverse

Name: fadA [H]

Synonym: Haur_4393

Alternate gene names: 159900906

Gene position: 5613396-5612218 (Counterclockwise)

Preceding gene: 159900907

Following gene: 159900904

Centisome position: 88.45

GC content: 52.84

Gene sequence:

>1179_bases
ATGAATGAAGCTGTGATTGTAGCTGGTGCGCGAACCGCCGTCGGCAAATCCAAGCGTGGAATGTTTCGCAATAGCCGGCC
TGATGATTTGGCAGCAGCAGCGATTAAAGCTGTGGTTGAACAAGCGCCAGGCCTCGACCCTCGCGAAATCGAAGATTTGA
TTTTGGGTTGTGCTATGCCCGAGGGCGAGCAAGGCCTGAATATGGCACGGATCGCATCGCTCCGCGCTGGTTTACCAATC
GATGTGCCCGCTCAAACCGTCAATCGTTTTTGCGCTTCAGGTTTGCAAACAATTGCCTTGGGTGCTGAACGAATTATGGC
TGGCGGCGCTGATGTGATCATCGCTGGTGGCGCTGAATCGATGAGCATGGTTCCAATGTCGGGCAATAAATTTGCACCAA
ACCCATGGATGGCTGAACACTACCCCGAAATTTACATCAACATGGGCTTGACCGCCGAAAATGTTGCTCGACAGTTCAAT
ATCAGCCGCGAAGATGCCGATGCCTTCTCGTATCGCTCGCATATGAAGGCGATCGAAGCAATTCAAGCAGGTCGCTTTGC
TGACGAAATTGTACCAGTCGATGTTGAGTTTGCCGAGGCCGAAGCTGGCGGTGCAATCAAGCGCAGCACCGCAACCGTCA
AGGTCGATGAAGGCCCACGCCGTGACACGACCTTAGAAGGCTTGGCCAAATTGCGCCCAGTGTTTCATGCCAAAGGCACA
GTCACTGCTGGCAATTCATCGCAAACCAGCGATGGCGCTGCCGCTGTGCTCTTGATGAACCGCCAAAAAGCCGATGAACT
TGGGCTAAAACCGTTGGCTCGCTTTATTGGCTTTGCAGTTGGTGGCGTTGGGCCTGAAGTCATGGGCATTGGCCCAGTCG
TGGCGATTCCAAAAGTTTTGAAGAAAACTGGCTTGAATCTCAGCGACATTGATTTGATTGAATTGAACGAGGCTTTTGGT
GCGCAAGCTTTGGCGGTTATTCGCGAGCTTGGCATCGACGAAAGCAAAACCAACGTCAATGGTGGCGCAATCGCCTTGGG
TCACCCACTTGGCTGTACTGGCGCGAAACTGACCGTCCAAATCATTAATGAACTTCGTCGCCGCAATGGCCGCTACGGCA
TGGTAACGATGTGTATCGGCGGTGGTATGGGCGCTGCGGGCATTTTCGAGTTGTTGTAA

Upstream 100 bases:

>100_bases
GGGTTGGGGTGAGGGAATGTAACTCAACCTGAATCCTGAACCCTATTTACTCATTCAACAATCGATCCCCATATCCATAC
CCATAAAGGAGTATTCAACG

Downstream 100 bases:

>100_bases
AGCTGAAACCACGAAGGACACGAAGCGCACTAAGAACCATAAACTAAATCTTCGTGAAACTTCGTGTCCTTCGTGGTTGA
AAAAATTTAAAATTCTAACT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNEAVIVAGARTAVGKSKRGMFRNSRPDDLAAAAIKAVVEQAPGLDPREIEDLILGCAMPEGEQGLNMARIASLRAGLPI
DVPAQTVNRFCASGLQTIALGAERIMAGGADVIIAGGAESMSMVPMSGNKFAPNPWMAEHYPEIYINMGLTAENVARQFN
ISREDADAFSYRSHMKAIEAIQAGRFADEIVPVDVEFAEAEAGGAIKRSTATVKVDEGPRRDTTLEGLAKLRPVFHAKGT
VTAGNSSQTSDGAAAVLLMNRQKADELGLKPLARFIGFAVGGVGPEVMGIGPVVAIPKVLKKTGLNLSDIDLIELNEAFG
AQALAVIRELGIDESKTNVNGGAIALGHPLGCTGAKLTVQIINELRRRNGRYGMVTMCIGGGMGAAGIFELL

Sequences:

>Translated_392_residues
MNEAVIVAGARTAVGKSKRGMFRNSRPDDLAAAAIKAVVEQAPGLDPREIEDLILGCAMPEGEQGLNMARIASLRAGLPI
DVPAQTVNRFCASGLQTIALGAERIMAGGADVIIAGGAESMSMVPMSGNKFAPNPWMAEHYPEIYINMGLTAENVARQFN
ISREDADAFSYRSHMKAIEAIQAGRFADEIVPVDVEFAEAEAGGAIKRSTATVKVDEGPRRDTTLEGLAKLRPVFHAKGT
VTAGNSSQTSDGAAAVLLMNRQKADELGLKPLARFIGFAVGGVGPEVMGIGPVVAIPKVLKKTGLNLSDIDLIELNEAFG
AQALAVIRELGIDESKTNVNGGAIALGHPLGCTGAKLTVQIINELRRRNGRYGMVTMCIGGGMGAAGIFELL
>Mature_392_residues
MNEAVIVAGARTAVGKSKRGMFRNSRPDDLAAAAIKAVVEQAPGLDPREIEDLILGCAMPEGEQGLNMARIASLRAGLPI
DVPAQTVNRFCASGLQTIALGAERIMAGGADVIIAGGAESMSMVPMSGNKFAPNPWMAEHYPEIYINMGLTAENVARQFN
ISREDADAFSYRSHMKAIEAIQAGRFADEIVPVDVEFAEAEAGGAIKRSTATVKVDEGPRRDTTLEGLAKLRPVFHAKGT
VTAGNSSQTSDGAAAVLLMNRQKADELGLKPLARFIGFAVGGVGPEVMGIGPVVAIPKVLKKTGLNLSDIDLIELNEAFG
AQALAVIRELGIDESKTNVNGGAIALGHPLGCTGAKLTVQIINELRRRNGRYGMVTMCIGGGMGAAGIFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=47.1794871794872, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=41.5617128463476, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=39.4936708860759, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.1287128712871, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=34.1013824884793, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=34.7043701799486, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=46.0759493670886, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=45.2554744525547, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=42.0398009950249, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=43.4567901234568, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1788683, Length=377, Percent_Identity=35.5437665782493, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=41.0579345088161, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=33.75, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=411, Percent_Identity=36.4963503649635, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17551802, Length=417, Percent_Identity=32.3741007194245, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=30.3030303030303, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=43.25, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=36.5, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=43.6724565756824, Blast_Score=310, Evalue=8e-85,
Organism=Drosophila melanogaster, GI17648125, Length=360, Percent_Identity=41.9444444444444, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=35.8208955223881, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=34.331797235023, Blast_Score=191, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41076; Mature: 41076

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVIVAGARTAVGKSKRGMFRNSRPDDLAAAAIKAVVEQAPGLDPREIEDLILGCAMP
CCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
EGEQGLNMARIASLRAGLPIDVPAQTVNRFCASGLQTIALGAERIMAGGADVIIAGGAES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCC
MSMVPMSGNKFAPNPWMAEHYPEIYINMGLTAENVARQFNISREDADAFSYRSHMKAIEA
CEEEECCCCCCCCCCCCHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IQAGRFADEIVPVDVEFAEAEAGGAIKRSTATVKVDEGPRRDTTLEGLAKLRPVFHAKGT
HHHCCCHHCEEECCEEECCCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
VTAGNSSQTSDGAAAVLLMNRQKADELGLKPLARFIGFAVGGVGPEVMGIGPVVAIPKVL
EECCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHH
KKTGLNLSDIDLIELNEAFGAQALAVIRELGIDESKTNVNGGAIALGHPLGCTGAKLTVQ
HHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHH
IINELRRRNGRYGMVTMCIGGGMGAAGIFELL
HHHHHHHCCCCCEEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MNEAVIVAGARTAVGKSKRGMFRNSRPDDLAAAAIKAVVEQAPGLDPREIEDLILGCAMP
CCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
EGEQGLNMARIASLRAGLPIDVPAQTVNRFCASGLQTIALGAERIMAGGADVIIAGGAES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCC
MSMVPMSGNKFAPNPWMAEHYPEIYINMGLTAENVARQFNISREDADAFSYRSHMKAIEA
CEEEECCCCCCCCCCCCHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IQAGRFADEIVPVDVEFAEAEAGGAIKRSTATVKVDEGPRRDTTLEGLAKLRPVFHAKGT
HHHCCCHHCEEECCEEECCCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
VTAGNSSQTSDGAAAVLLMNRQKADELGLKPLARFIGFAVGGVGPEVMGIGPVVAIPKVL
EECCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHH
KKTGLNLSDIDLIELNEAFGAQALAVIRELGIDESKTNVNGGAIALGHPLGCTGAKLTVQ
HHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHH
IINELRRRNGRYGMVTMCIGGGMGAAGIFELL
HHHHHHHCCCCCEEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]