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The map label for this gene is mscS [H]

Identifier: 159900895

GI number: 159900895

Start: 5598003

End: 5598791

Strand: Reverse

Name: mscS [H]

Synonym: Haur_4382

Alternate gene names: 159900895

Gene position: 5598791-5598003 (Counterclockwise)

Preceding gene: 159900896

Following gene: 159900894

Centisome position: 88.22

GC content: 51.96

Gene sequence:

>789_bases
ATGGATTGGAATCTGTGGTCGGAACAAGCGCAGGATTTTGCGATTCGGGTGCTGCCACGAATTTTAGCGGCAATTGTGGT
TTTGCTCACCTTACGCTATGGCATTCGATTAGCCAATGGCGCAACCAATCGGGTATTAAAGCGGGTGGAATTACCCAGCG
AAGCTGAAAACTTGATTCTGCGCTTGGTGCGAATTTTGGTGATAGTGGCTGGTTTGGTGATTGTGTTGCTAGTGATGGGC
TGGGGCCAACTGGCGCTTTCGTTTGTGGCAGGCTTGGGGGTAAGCGGCTTGATCATCGGTTTTGCCTTACAAGACATCAC
AAAAAACTTGGCCGCTGGGATTTTGTTGCTGTTTCAGCGCCCGTTTCGGGTGGGTGACCGCATTTTAGTTGGCAACGACG
AGGGCACAGTCACCGATATTGCAGTACGTGCCACTACTATGCGCACTGCCGATGGTCGCGAAGTGATGGTGCCGAATGCC
ACGATTTACACTGGCACAATTACCAATCTGACCCGCTATGTGCAGCGTCGCCATAGCGTTGAACTGACCCTCAAACGCGA
TGTGGATTCCGCCCCAGTTGTCCAGGGCTTAGCTGAAATAGCTCGGACAACCGAGCATGTGCTCGAAAAACCTGCTGCCG
AGGTGCTGATTACCGCCGTTAAAGCTGATGGTTTGATTGTCGAAACCCGTTTTTGGTTGCCATCCAAAGGTATAGATAGC
AACGTAGTACGCTCGAATTTAGCTGGCCGCTTGCGAGCCAAAGCCCTAGCCGAGGATTGGCTGGCATGA

Upstream 100 bases:

>100_bases
GTTAACTGATGTTGGCTATAAAAATATTACGATTCGCGCCTCGAATGGCTCCGTGCTCTATTCAACAAAATCGCAATAAG
CCAAGTATGAGGGTTATGGT

Downstream 100 bases:

>100_bases
TCATCGATCTCAATGCCGATTTGGGCGAAGGCAGCGATTTTGATGCTGAATTAATGTCGCTGCTTTCGTCGTGCAATATT
GCTTGTGGCGGCCATGCTGG

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MDWNLWSEQAQDFAIRVLPRILAAIVVLLTLRYGIRLANGATNRVLKRVELPSEAENLILRLVRILVIVAGLVIVLLVMG
WGQLALSFVAGLGVSGLIIGFALQDITKNLAAGILLLFQRPFRVGDRILVGNDEGTVTDIAVRATTMRTADGREVMVPNA
TIYTGTITNLTRYVQRRHSVELTLKRDVDSAPVVQGLAEIARTTEHVLEKPAAEVLITAVKADGLIVETRFWLPSKGIDS
NVVRSNLAGRLRAKALAEDWLA

Sequences:

>Translated_262_residues
MDWNLWSEQAQDFAIRVLPRILAAIVVLLTLRYGIRLANGATNRVLKRVELPSEAENLILRLVRILVIVAGLVIVLLVMG
WGQLALSFVAGLGVSGLIIGFALQDITKNLAAGILLLFQRPFRVGDRILVGNDEGTVTDIAVRATTMRTADGREVMVPNA
TIYTGTITNLTRYVQRRHSVELTLKRDVDSAPVVQGLAEIARTTEHVLEKPAAEVLITAVKADGLIVETRFWLPSKGIDS
NVVRSNLAGRLRAKALAEDWLA
>Mature_262_residues
MDWNLWSEQAQDFAIRVLPRILAAIVVLLTLRYGIRLANGATNRVLKRVELPSEAENLILRLVRILVIVAGLVIVLLVMG
WGQLALSFVAGLGVSGLIIGFALQDITKNLAAGILLLFQRPFRVGDRILVGNDEGTVTDIAVRATTMRTADGREVMVPNA
TIYTGTITNLTRYVQRRHSVELTLKRDVDSAPVVQGLAEIARTTEHVLEKPAAEVLITAVKADGLIVETRFWLPSKGIDS
NVVRSNLAGRLRAKALAEDWLA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=218, Percent_Identity=31.1926605504587, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786670, Length=192, Percent_Identity=31.25, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI2367355, Length=178, Percent_Identity=33.7078651685393, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787591, Length=127, Percent_Identity=37.007874015748, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 28674; Mature: 28674

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWNLWSEQAQDFAIRVLPRILAAIVVLLTLRYGIRLANGATNRVLKRVELPSEAENLIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHH
RLVRILVIVAGLVIVLLVMGWGQLALSFVAGLGVSGLIIGFALQDITKNLAAGILLLFQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFRVGDRILVGNDEGTVTDIAVRATTMRTADGREVMVPNATIYTGTITNLTRYVQRRHSV
CHHCCCEEEEECCCCCEEHHEEEEEEEECCCCCEEECCCCEEEECHHHHHHHHHHHHHCE
ELTLKRDVDSAPVVQGLAEIARTTEHVLEKPAAEVLITAVKADGLIVETRFWLPSKGIDS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEECCCCCCCCH
NVVRSNLAGRLRAKALAEDWLA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDWNLWSEQAQDFAIRVLPRILAAIVVLLTLRYGIRLANGATNRVLKRVELPSEAENLIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHH
RLVRILVIVAGLVIVLLVMGWGQLALSFVAGLGVSGLIIGFALQDITKNLAAGILLLFQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFRVGDRILVGNDEGTVTDIAVRATTMRTADGREVMVPNATIYTGTITNLTRYVQRRHSV
CHHCCCEEEEECCCCCEEHHEEEEEEEECCCCCEEECCCCEEEECHHHHHHHHHHHHHCE
ELTLKRDVDSAPVVQGLAEIARTTEHVLEKPAAEVLITAVKADGLIVETRFWLPSKGIDS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEECCCCCCCCH
NVVRSNLAGRLRAKALAEDWLA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]