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The map label for this gene is apt

Identifier: 159900892

GI number: 159900892

Start: 5596235

End: 5596753

Strand: Reverse

Name: apt

Synonym: Haur_4379

Alternate gene names: 159900892

Gene position: 5596753-5596235 (Counterclockwise)

Preceding gene: 159900893

Following gene: 159900891

Centisome position: 88.19

GC content: 47.21

Gene sequence:

>519_bases
ATGAGCCTCGATTTAACCCAGTTTGTTCGCAATATCCCCGATTTTCCAATTCCTGGGGTTCAGTTTAAAGATATTACGCC
GTTGTTGGGCAATGCTCAAGCTTTCGATGCAGCGATTGAGCACTTTGCTCAGCGCTATGCCAACCAACAATTACAAGCGA
TTGTCGGGATTGAATCACGTGGTTTTATTTTTGGTGCGCCTTTGGCATTACGGTTGGGGATTGGCTTTGTGCCAATTCGT
AAACCTGGCAAATTGCCAGCCCAAACCATTGGCGTAGATTATAGCTTGGAATATGGCACTAATCGCTTGGAAATTCATAA
CGATGCCTTGCAAGCTGGCGATCGGGTTGTGGTTGTCGATGATCTCTTGGCAACTGGGGGAACCGTGGTCGCGGCCTGCG
ATTTGCTCAACCAACTCGGGGCTGAGGTGGTTGAGGCAGCTTTTTTAATTGAATTGACCTTTTTAGGTGGGCGCGAAAAA
CTTGGCAATCGGCCATTTTACGCCCAAATTCAATACTAA

Upstream 100 bases:

>100_bases
CCGAATGGCGCAAGATTGTTGATGGTCGGCTAACCCAATTAGTGGCTGCTGCTCGCCGTTATATTGAAGCTGGGCCAGGT
GCGGCCAAGGAAATTATTGA

Downstream 100 bases:

>100_bases
ACCGACAATGAGGCCAGCAAGCCCCTACCGCATGCTGGTCTCAGGTTGTCCAATGGCGGGAGGTTGGTGCGATGGGTTAC
GCTGCCGATCTTTGTAATCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESRGFIFGAPLALRLGIGFVPIR
KPGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVDDLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREK
LGNRPFYAQIQY

Sequences:

>Translated_172_residues
MSLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESRGFIFGAPLALRLGIGFVPIR
KPGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVDDLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREK
LGNRPFYAQIQY
>Mature_171_residues
SLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESRGFIFGAPLALRLGIGFVPIRK
PGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVDDLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREKL
GNRPFYAQIQY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=54.4378698224852, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=52.8, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=53.5031847133758, Blast_Score=179, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=44.7058823529412, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=169, Percent_Identity=42.603550295858, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320649, Length=157, Percent_Identity=42.0382165605096, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=41.4634146341463, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_HERA2 (A9AYX1)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547139.1
- ProteinModelPortal:   A9AYX1
- SMR:   A9AYX1
- GeneID:   5736936
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4379
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   HAUR316274:HAUR_4379-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18700; Mature: 18569

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESR
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFIFGAPLALRLGIGFVPIRKPGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVD
CEEEECCHHHHHCCCEEECCCCCCCCHHHCCCEEEECCCCCEEEEECHHHHCCCEEEEEE
DLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREKLGNRPFYAQIQY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCEEEEECC
>Mature Secondary Structure 
SLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESR
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFIFGAPLALRLGIGFVPIRKPGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVD
CEEEECCHHHHHCCCEEECCCCCCCCHHHCCCEEEECCCCCEEEEECHHHHCCCEEEEEE
DLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREKLGNRPFYAQIQY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA