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The map label for this gene is pyrD [H]

Identifier: 159900872

GI number: 159900872

Start: 5567403

End: 5568473

Strand: Reverse

Name: pyrD [H]

Synonym: Haur_4359

Alternate gene names: 159900872

Gene position: 5568473-5567403 (Counterclockwise)

Preceding gene: 159900873

Following gene: 159900871

Centisome position: 87.74

GC content: 47.43

Gene sequence:

>1071_bases
ATGCGCAGCTATCAGCTTGCAAAAGCACTTTTGTTTCGTTTACCACCAGAAAAAGCTCATCGGTTAACCACTTTAGGCCT
AGATTTGGCCACTCGTTTACCATTTACCTCAGCTTTATTCCGTTCCTTCCATCACAATGACCCATTGCTTAAAACCAATT
TATGTGGGTTAACGTTTAATAATCCGGTTGGTTTAGCAGCAGGTTTCGATAAAGATGGCACGCATATCCGTGGAATGAGT
CAATTGGGTTTTGGTTTTTTGGAATTGGGCACAGTTACGCCCAAGCCTCAAGCTGGCAATGAACAGCCGCGTTTATTTCG
TTTAATCGAGGATCATGCATTAATCAATCGAATGGGATTTAATAATGCAGGAATTGCAGCGCTTGCTCAACGTTTAGCCA
AACAGCCACGCATCATTCCACTTGGGATTAATTTGGGCAAGAATAAAATTACGCCAAACGAACAAGCTGCTGATGATTAT
CGCCAAGGTATTAATTTGCTTGGTGAATATGCCGATTACATTGTGATCAATATTTCTTCGCCGAATACGCCTGGTTTGCG
CGAACTCAGCCGCCGCGAGCCATTGACTGAACTATTGCAGGTTGTCAAAACTGCCCGCCAACAATTACGCCATCAAGCCC
CGTTGTTCGTTAAACTCTCGCCCGATGAAGATCGCGAAGGCTTGGAGGCAGCGCTTGGCGCAGCCCTCGACGCTGGAGTT
GATGGGATTATCGCCACCAATACAACCGTCAGTCGCGAAAATTTACGTTCTGCTCAGCAAACCGAAACTGGCGGCTTAAG
TGGCGCTCCGCTCAAAACCAAGGCCTTGGCAACCCTCAAATATATCTATCAAACAACCAACGGCAAATTGCCCTTGATTG
GCGTTGGCGGAATTGCCAACGGCCAAGATGCTTACGAACGGATTTTGGCTGGCGCGAGTGCCGTGCAACTCTATACCAGC
CTGATCTATGCCGGGCCACAATTGGTTGGCACAATCAACCGCGAGCTAGCAGCATTACTACGGCGCGATGGCTTTGATTC
AATTCAAACAGCCGTTGGGTCAGCAGTTTAG

Upstream 100 bases:

>100_bases
TATGTGGGATATGTGGGATATTTCATGGCCCGCAAATGATTGTGTATAATCGCCAAGGCCAACGATAGTCGCGGCCAAAA
TCATAGATTTGAGGCTTTGT

Downstream 100 bases:

>100_bases
CGCTAGAGAGGGGACGCAAAGTCACCCGTATGGCAAAATCAAGATGACACCAGAGCATGACATAACTGGTTGCGCTGCCC
TAGGTGGCGTGGTAAGATGC

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRSYQLAKALLFRLPPEKAHRLTTLGLDLATRLPFTSALFRSFHHNDPLLKTNLCGLTFNNPVGLAAGFDKDGTHIRGMS
QLGFGFLELGTVTPKPQAGNEQPRLFRLIEDHALINRMGFNNAGIAALAQRLAKQPRIIPLGINLGKNKITPNEQAADDY
RQGINLLGEYADYIVINISSPNTPGLRELSRREPLTELLQVVKTARQQLRHQAPLFVKLSPDEDREGLEAALGAALDAGV
DGIIATNTTVSRENLRSAQQTETGGLSGAPLKTKALATLKYIYQTTNGKLPLIGVGGIANGQDAYERILAGASAVQLYTS
LIYAGPQLVGTINRELAALLRRDGFDSIQTAVGSAV

Sequences:

>Translated_356_residues
MRSYQLAKALLFRLPPEKAHRLTTLGLDLATRLPFTSALFRSFHHNDPLLKTNLCGLTFNNPVGLAAGFDKDGTHIRGMS
QLGFGFLELGTVTPKPQAGNEQPRLFRLIEDHALINRMGFNNAGIAALAQRLAKQPRIIPLGINLGKNKITPNEQAADDY
RQGINLLGEYADYIVINISSPNTPGLRELSRREPLTELLQVVKTARQQLRHQAPLFVKLSPDEDREGLEAALGAALDAGV
DGIIATNTTVSRENLRSAQQTETGGLSGAPLKTKALATLKYIYQTTNGKLPLIGVGGIANGQDAYERILAGASAVQLYTS
LIYAGPQLVGTINRELAALLRRDGFDSIQTAVGSAV
>Mature_356_residues
MRSYQLAKALLFRLPPEKAHRLTTLGLDLATRLPFTSALFRSFHHNDPLLKTNLCGLTFNNPVGLAAGFDKDGTHIRGMS
QLGFGFLELGTVTPKPQAGNEQPRLFRLIEDHALINRMGFNNAGIAALAQRLAKQPRIIPLGINLGKNKITPNEQAADDY
RQGINLLGEYADYIVINISSPNTPGLRELSRREPLTELLQVVKTARQQLRHQAPLFVKLSPDEDREGLEAALGAALDAGV
DGIIATNTTVSRENLRSAQQTETGGLSGAPLKTKALATLKYIYQTTNGKLPLIGVGGIANGQDAYERILAGASAVQLYTS
LIYAGPQLVGTINRELAALLRRDGFDSIQTAVGSAV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=352, Percent_Identity=46.5909090909091, Blast_Score=305, Evalue=5e-83,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=46.1077844311377, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI87082059, Length=335, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509475, Length=319, Percent_Identity=46.3949843260188, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6322633, Length=318, Percent_Identity=25.4716981132075, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281361352, Length=350, Percent_Identity=46, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17137316, Length=350, Percent_Identity=46, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38451; Mature: 38451

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSYQLAKALLFRLPPEKAHRLTTLGLDLATRLPFTSALFRSFHHNDPLLKTNLCGLTFN
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCEEEC
NPVGLAAGFDKDGTHIRGMSQLGFGFLELGTVTPKPQAGNEQPRLFRLIEDHALINRMGF
CCCCEECCCCCCCCEECCHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NNAGIAALAQRLAKQPRIIPLGINLGKNKITPNEQAADDYRQGINLLGEYADYIVINISS
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
PNTPGLRELSRREPLTELLQVVKTARQQLRHQAPLFVKLSPDEDREGLEAALGAALDAGV
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCC
DGIIATNTTVSRENLRSAQQTETGGLSGAPLKTKALATLKYIYQTTNGKLPLIGVGGIAN
CCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GQDAYERILAGASAVQLYTSLIYAGPQLVGTINRELAALLRRDGFDSIQTAVGSAV
CHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MRSYQLAKALLFRLPPEKAHRLTTLGLDLATRLPFTSALFRSFHHNDPLLKTNLCGLTFN
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCEEEC
NPVGLAAGFDKDGTHIRGMSQLGFGFLELGTVTPKPQAGNEQPRLFRLIEDHALINRMGF
CCCCEECCCCCCCCEECCHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NNAGIAALAQRLAKQPRIIPLGINLGKNKITPNEQAADDYRQGINLLGEYADYIVINISS
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
PNTPGLRELSRREPLTELLQVVKTARQQLRHQAPLFVKLSPDEDREGLEAALGAALDAGV
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCC
DGIIATNTTVSRENLRSAQQTETGGLSGAPLKTKALATLKYIYQTTNGKLPLIGVGGIAN
CCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GQDAYERILAGASAVQLYTSLIYAGPQLVGTINRELAALLRRDGFDSIQTAVGSAV
CHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA