Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 159900566

GI number: 159900566

Start: 5171007

End: 5171489

Strand: Direct

Name: folK [H]

Synonym: Haur_4053

Alternate gene names: 159900566

Gene position: 5171007-5171489 (Clockwise)

Preceding gene: 159900565

Following gene: 159900569

Centisome position: 81.48

GC content: 51.76

Gene sequence:

>483_bases
GTGACCATCGTTTATTTAGCCATCGGCAGCAACCAAGGCGATCGTTTAGCCAACTTACAAGCGGGCTTAGCCGCTTTAGC
TCCCGCTGTGCAACTAACCAACTACTCAAGCGTTTATGAAACCGCAGCGGCCTACGTTGAAGATCAACCGCCGTTTTTGA
ATGCGGTGGTTGCTGGCACAACCGAATTAGCGCCACATGCGCTGTTAGCCTTGCTCAAGCAGATAGAGCACGATTGTGGC
CGCCGACCTGGCTTGCGTTACGGCCCGCGCCCGCTTGATCTTGATATTTTGTTGTATGGCGAGCTTGAATTGCAAACCAA
TGACTTGATTATTCCACATTTGCGGATGTTCGAGCGTGATTTTGTGTTGCGACCCTTGGCCGAAATCGCCCCCAACCAGG
TCAATGCTGAGCAACTTGCCCAAGCAACCCAAGGCAGCGTTTTAGCTGTTGTCTACTCAGCCAAGCAATTACAGGGCAGA
TGA

Upstream 100 bases:

>100_bases
TAGAATGGATTGTCGATTACGAGGGCAAAAATCATCAAGCTTTGTTTGAAATGGGCTATCGTGATGCCCTCCGTGCTTTC
GATCAACGCCAGGAGCAAGC

Downstream 100 bases:

>100_bases
AAAAATTATTTTTTAGCGCGTCTGACCACAATAGCAACCATCATCGAGCCACGATTATCGCTCAAACAGACATCGGCACA
ATGCGCATCATTAATTCCAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MTIVYLAIGSNQGDRLANLQAGLAALAPAVQLTNYSSVYETAAAYVEDQPPFLNAVVAGTTELAPHALLALLKQIEHDCG
RRPGLRYGPRPLDLDILLYGELELQTNDLIIPHLRMFERDFVLRPLAEIAPNQVNAEQLAQATQGSVLAVVYSAKQLQGR

Sequences:

>Translated_160_residues
MTIVYLAIGSNQGDRLANLQAGLAALAPAVQLTNYSSVYETAAAYVEDQPPFLNAVVAGTTELAPHALLALLKQIEHDCG
RRPGLRYGPRPLDLDILLYGELELQTNDLIIPHLRMFERDFVLRPLAEIAPNQVNAEQLAQATQGSVLAVVYSAKQLQGR
>Mature_159_residues
TIVYLAIGSNQGDRLANLQAGLAALAPAVQLTNYSSVYETAAAYVEDQPPFLNAVVAGTTELAPHALLALLKQIEHDCGR
RPGLRYGPRPLDLDILLYGELELQTNDLIIPHLRMFERDFVLRPLAEIAPNQVNAEQLAQATQGSVLAVVYSAKQLQGR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=146, Percent_Identity=45.2054794520548, Blast_Score=104, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324073, Length=133, Percent_Identity=43.609022556391, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17418; Mature: 17287

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIVYLAIGSNQGDRLANLQAGLAALAPAVQLTNYSSVYETAAAYVEDQPPFLNAVVAGT
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHEECCC
TELAPHALLALLKQIEHDCGRRPGLRYGPRPLDLDILLYGELELQTNDLIIPHLRMFERD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCEECHHHHHHHHH
FVLRPLAEIAPNQVNAEQLAQATQGSVLAVVYSAKQLQGR
HHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEHHHHCCC
>Mature Secondary Structure 
TIVYLAIGSNQGDRLANLQAGLAALAPAVQLTNYSSVYETAAAYVEDQPPFLNAVVAGT
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHEECCC
TELAPHALLALLKQIEHDCGRRPGLRYGPRPLDLDILLYGELELQTNDLIIPHLRMFERD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCEECHHHHHHHHH
FVLRPLAEIAPNQVNAEQLAQATQGSVLAVVYSAKQLQGR
HHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]