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The map label for this gene is mmgB [H]

Identifier: 159900481

GI number: 159900481

Start: 5046458

End: 5047309

Strand: Direct

Name: mmgB [H]

Synonym: Haur_3968

Alternate gene names: 159900481

Gene position: 5046458-5047309 (Clockwise)

Preceding gene: 159900480

Following gene: 159900482

Centisome position: 79.51

GC content: 58.45

Gene sequence:

>852_bases
ATGGCTATCAAAAAAGTTGGCGTGATTGGCGCTGGTGTGATGGGTATCGGGGTTGGCCAGAGCCTGGCCCAGGGCGGCTA
CGAGGTAGTCCTGATCGACATCAACGATCAGATTCTGGAGCACGCCGAGCGCGAAATCCGCAGCAACCTGCGACTCTTCA
AAATGCTTAACAAAGGTGTGGAGCTGGATATCGCCGCGACCCTCGGCCGTATCACCTTCGCCACTGACTACGAGCACCTC
AGCGACGCCGACTTCGTGGTTGAGAACGTGGTTGAGAATTGGGAGATCAAGAAGGCCGTCCACCTCAAGCTGGATGCCAT
CTGCCCTGCCCACACGGTGGTCGCCGTCAATACCTCGGCGATCTCGATCACCCGCGTCGGCTCGCTGACCAAGCGCCCGT
CGCAGATCGTCGGCATGCACTTTATGAACCCGGTACCCATGAAGCCGACCGTCGAGGTGATCCGCGGCTACCACACCTCC
GATGCGACCATCGCCACCGCCAAGGAATTGCTGGCCGGCATGGGCAAGAAAGGTGTCGTCGTACAGGATATGCCCGGCTT
TGTTTCCAACCGGGTCTTGATGCTGACGGTCAACGAGGCGGTCTTCCTGGTGCAGGATCAGGTCGCCAGTGCCGAAGAAG
TCGACACGATCTTCAAAGAATGCTTCGGCCACAAGATGGGTCCGCTGGAAACCGCCGACCTGATCGGCCTGGATACGATC
CTTTACTCGATCGAGGTGCTCTACGAGAGCTACAACGATAGCAAGTACCGTCCCTGCCCGCTGCTCAAGAAAATGGTCGA
CGCCGGCCTGCACGGCCGCAAAAACGGCAAAGGCTTCTATACCTACGAGTAG

Upstream 100 bases:

>100_bases
TGCGATTGAAATGATGCTGATCGACGCGATCGAACATTCAAGCGAGAGCGCGGCGGAATCTGTTTCCCGGGTCTGATAAC
GTAATTTTATGGAGGAATCA

Downstream 100 bases:

>100_bases
CGCTTCACCGCATATTCCGTCCGGGCGACGGTTCGTCGTGACCGGAGATTGATATGGCCATTTTTTAATGTATTTCAAGG
AGACAATTCCATGACCACCG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAIKKVGVIGAGVMGIGVGQSLAQGGYEVVLIDINDQILEHAEREIRSNLRLFKMLNKGVELDIAATLGRITFATDYEHL
SDADFVVENVVENWEIKKAVHLKLDAICPAHTVVAVNTSAISITRVGSLTKRPSQIVGMHFMNPVPMKPTVEVIRGYHTS
DATIATAKELLAGMGKKGVVVQDMPGFVSNRVLMLTVNEAVFLVQDQVASAEEVDTIFKECFGHKMGPLETADLIGLDTI
LYSIEVLYESYNDSKYRPCPLLKKMVDAGLHGRKNGKGFYTYE

Sequences:

>Translated_283_residues
MAIKKVGVIGAGVMGIGVGQSLAQGGYEVVLIDINDQILEHAEREIRSNLRLFKMLNKGVELDIAATLGRITFATDYEHL
SDADFVVENVVENWEIKKAVHLKLDAICPAHTVVAVNTSAISITRVGSLTKRPSQIVGMHFMNPVPMKPTVEVIRGYHTS
DATIATAKELLAGMGKKGVVVQDMPGFVSNRVLMLTVNEAVFLVQDQVASAEEVDTIFKECFGHKMGPLETADLIGLDTI
LYSIEVLYESYNDSKYRPCPLLKKMVDAGLHGRKNGKGFYTYE
>Mature_282_residues
AIKKVGVIGAGVMGIGVGQSLAQGGYEVVLIDINDQILEHAEREIRSNLRLFKMLNKGVELDIAATLGRITFATDYEHLS
DADFVVENVVENWEIKKAVHLKLDAICPAHTVVAVNTSAISITRVGSLTKRPSQIVGMHFMNPVPMKPTVEVIRGYHTSD
ATIATAKELLAGMGKKGVVVQDMPGFVSNRVLMLTVNEAVFLVQDQVASAEEVDTIFKECFGHKMGPLETADLIGLDTIL
YSIEVLYESYNDSKYRPCPLLKKMVDAGLHGRKNGKGFYTYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=36.1111111111111, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=34.0983606557377, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI20127408, Length=288, Percent_Identity=31.25, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=28.3898305084746, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=34.1637010676157, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=34.4827586206897, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790281, Length=270, Percent_Identity=36.2962962962963, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=35.8620689655172, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=32.7526132404181, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=30.7420494699647, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=30.6620209059233, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=31.6725978647687, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=31.4487632508834, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=31.4487632508834, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=31.4487632508834, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=30.3886925795053, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=33.2155477031802, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=33.2155477031802, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=33.2155477031802, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=27.9166666666667, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45549573, Length=260, Percent_Identity=27.3076923076923, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30997; Mature: 30866

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKKVGVIGAGVMGIGVGQSLAQGGYEVVLIDINDQILEHAEREIRSNLRLFKMLNKGV
CCCCCCCEEECCHHHHCCCHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
ELDIAATLGRITFATDYEHLSDADFVVENVVENWEIKKAVHLKLDAICPAHTVVAVNTSA
EEEEEEHHCCEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEEEEECCE
ISITRVGSLTKRPSQIVGMHFMNPVPMKPTVEVIRGYHTSDATIATAKELLAGMGKKGVV
EEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEE
VQDMPGFVSNRVLMLTVNEAVFLVQDQVASAEEVDTIFKECFGHKMGPLETADLIGLDTI
EECCCCHHHCCEEEEEECCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LYSIEVLYESYNDSKYRPCPLLKKMVDAGLHGRKNGKGFYTYE
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECC
>Mature Secondary Structure 
AIKKVGVIGAGVMGIGVGQSLAQGGYEVVLIDINDQILEHAEREIRSNLRLFKMLNKGV
CCCCCCEEECCHHHHCCCHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
ELDIAATLGRITFATDYEHLSDADFVVENVVENWEIKKAVHLKLDAICPAHTVVAVNTSA
EEEEEEHHCCEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEEEEECCE
ISITRVGSLTKRPSQIVGMHFMNPVPMKPTVEVIRGYHTSDATIATAKELLAGMGKKGVV
EEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEE
VQDMPGFVSNRVLMLTVNEAVFLVQDQVASAEEVDTIFKECFGHKMGPLETADLIGLDTI
EECCCCHHHCCEEEEEECCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LYSIEVLYESYNDSKYRPCPLLKKMVDAGLHGRKNGKGFYTYE
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]