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The map label for this gene is phhA [H]

Identifier: 159900364

GI number: 159900364

Start: 4829404

End: 4830147

Strand: Reverse

Name: phhA [H]

Synonym: Haur_3847

Alternate gene names: 159900364

Gene position: 4830147-4829404 (Counterclockwise)

Preceding gene: 159900365

Following gene: 159900358

Centisome position: 76.11

GC content: 52.42

Gene sequence:

>744_bases
ATGGCCACCGCATCGCCAACGCTCAGCCGCTTGGAATATCCACAAGAAGATCACGATACATGGGCAGCGCTGTGGCAGCG
TCAAATGCCCCTCGCGCAACAACATGCTTGCAAGCTATTTCTCGAAGGCATCGATATTTTGAATCTCGATCGCACCCACT
TGCCCGACCCATTAGCAGTTAGCGATTACCTGAACACGCTGACTGGCTGGGCTTTGGGCGATGCCCAAAATGCCTATCTT
GGGCCAACCGAGTGGTTTGAGCATATCGCTGAGCGCCGTTTTCCGGTCACCAACTATATTCGCCGCCCGCATGAACTCGA
ATTTACGCCGCTGCCCGATTTGTTTCACGAGTATTTTGGCCACTTGCCAGCCTTTACCAACCGCGAATTTGCCGATATTG
CCCAATTGTTCGGGCCGCTGTATCTCTCGGCCAAAGATGAACGCCAGCAATTAGGCATTGCACGGATTTGGTGGTTTAGC
ACCGAGTTTGGTTTGTTGCGTGAAAACGGCGAGTTGAAGGTTTTGGGGGCTGGGTTGCTCTCATCTCCAGGCGAGTTATT
GCACGCGCTCAATCCCGAAACCCCGCGCTATGAGTTTGATATTGAACGGGTTGCCGACACCGCTTCAGCACCCTATGGCT
ACCACGAGCACTACTTCATCCTCAATAGCCTCGATCACTTGCGCTCAATCGTCTATGAATATGCCGAGTTAGAAGGCTTA
CCCAAGCCTCAATTGCCGTTATAA

Upstream 100 bases:

>100_bases
TTTGGTACAATAGCGAGGCAACTATTTTGGCACTGCTGCCACTCCCACTCCCATGCTTGGGCTTGGTTGGCAGCCTATGG
CTTACACAAAGGAGTGATCA

Downstream 100 bases:

>100_bases
AACCACAACATGCCCTCACCCCCTAGCCCCCTCTCCCGCTCAGCGAGCGAGGGGGAAGCAGCCCAGCATGACGGGTGGAA
TGCCCCTCGCCCGCCGCAGT

Product: aromatic amino acid hydroxylase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MATASPTLSRLEYPQEDHDTWAALWQRQMPLAQQHACKLFLEGIDILNLDRTHLPDPLAVSDYLNTLTGWALGDAQNAYL
GPTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFGHLPAFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFS
TEFGLLRENGELKVLGAGLLSSPGELLHALNPETPRYEFDIERVADTASAPYGYHEHYFILNSLDHLRSIVYEYAELEGL
PKPQLPL

Sequences:

>Translated_247_residues
MATASPTLSRLEYPQEDHDTWAALWQRQMPLAQQHACKLFLEGIDILNLDRTHLPDPLAVSDYLNTLTGWALGDAQNAYL
GPTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFGHLPAFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFS
TEFGLLRENGELKVLGAGLLSSPGELLHALNPETPRYEFDIERVADTASAPYGYHEHYFILNSLDHLRSIVYEYAELEGL
PKPQLPL
>Mature_246_residues
ATASPTLSRLEYPQEDHDTWAALWQRQMPLAQQHACKLFLEGIDILNLDRTHLPDPLAVSDYLNTLTGWALGDAQNAYLG
PTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFGHLPAFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFST
EFGLLRENGELKVLGAGLLSSPGELLHALNPETPRYEFDIERVADTASAPYGYHEHYFILNSLDHLRSIVYEYAELEGLP
KPQLPL

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=232, Percent_Identity=34.051724137931, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI88900505, Length=232, Percent_Identity=34.051724137931, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI31795563, Length=231, Percent_Identity=31.6017316017316, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI88900501, Length=232, Percent_Identity=34.051724137931, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4759248, Length=231, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4557819, Length=240, Percent_Identity=30.8333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71980736, Length=229, Percent_Identity=31.0043668122271, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI115533973, Length=227, Percent_Identity=31.2775330396476, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI115532103, Length=227, Percent_Identity=31.2775330396476, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17531391, Length=234, Percent_Identity=31.1965811965812, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71980731, Length=152, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI62472054, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24660393, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136774, Length=222, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136776, Length=225, Percent_Identity=32.8888888888889, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24654994, Length=232, Percent_Identity=30.6034482758621, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 28431; Mature: 28300

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATASPTLSRLEYPQEDHDTWAALWQRQMPLAQQHACKLFLEGIDILNLDRTHLPDPLAV
CCCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCHHCCCCCCHH
SDYLNTLTGWALGDAQNAYLGPTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
HLPAFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFSTEFGLLRENGELKVLGAGLL
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEECCCCEEEEECCHH
SSPGELLHALNPETPRYEFDIERVADTASAPYGYHEHYFILNSLDHLRSIVYEYAELEGL
CCHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PKPQLPL
CCCCCCC
>Mature Secondary Structure 
ATASPTLSRLEYPQEDHDTWAALWQRQMPLAQQHACKLFLEGIDILNLDRTHLPDPLAV
CCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCHHCCCCCCHH
SDYLNTLTGWALGDAQNAYLGPTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
HLPAFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFSTEFGLLRENGELKVLGAGLL
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEECCCCEEEEECCHH
SSPGELLHALNPETPRYEFDIERVADTASAPYGYHEHYFILNSLDHLRSIVYEYAELEGL
CCHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PKPQLPL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]