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The map label for this gene is pbpA [H]

Identifier: 159900331

GI number: 159900331

Start: 4787180

End: 4788919

Strand: Reverse

Name: pbpA [H]

Synonym: Haur_3814

Alternate gene names: 159900331

Gene position: 4788919-4787180 (Counterclockwise)

Preceding gene: 159900332

Following gene: 159900330

Centisome position: 75.46

GC content: 51.61

Gene sequence:

>1740_bases
ATGCAGCGTTTCTTGAAATCACTAGCAGGGTTAATCGCGGTTGGCTTAATTATCTATGGCATGGTGCCGTGGTCGAAAGA
AGAACATTGGTTGCCATGTTTATGGATCGCGACCATCTTAGGTGGTTTTGCGATTTGGCCGATTCGCACCCAACGCGCCA
CTGGGATTTATACTGCAACCCAAAACTTAGCCTTATTTATGATCATCGGTTTTACCATGTTGACGCTGCAATTGCTGCGT
ACCCAAGTGATTCGCGCCGATGAGATTTATAATCGGGTGGTTGCCGAGGATGATGGCAACATTATTAGCAATATTCGCTT
GGTTCGTAGCACCAATCGCATCAAGCGCGGCGCAATTTTCGATTCGCAAGGGGTAACGCTCGCCGAAAATGTGATCGTCT
CGGATAATCGCTCGTATCGCACCTACCCAATTGCCAATCAATACGATATGCGGGCTTTTGGCCATACCCTTGGCTATGTC
AGCAGCATCTATGGCTTGTATGGCTTAGAAAGTAGCTATAACGAATATTTGGCTGGTGGCAAGGGCAATAGCTGGCAAAA
TTTGCAAAATCAGCTGTTTAGCCGCCCGCGCGAAGGCAATAACGTGCAACTGACGATCAATGCGCAACTACAAGATCGCG
CCTTCAAGGCGCTCGATGGGCGGGTTGGTTCGGTCGTGGTGATCGATGTCAAAACCGGAGCAATTCGGGCGATGGTCAGC
ACGCCCAGCTTTGATCCTTCGCAATTAACCTTGCGGCTTGATGCCGAAGATTACTCGGCAGAAAGCGATCGGGTGGTCAA
TTATTGGAACTCGTTGATCAGCGATGAATCGCGGCCTCTCGTATTTCGCTCGACCCAAGGCCAATATCCCCCAGGCTCGA
CTTTTAAAACTGTAACCGCAATTGGGGTGCTGAATAATCCTGAGGTTGGCAAACCTGAAGACATTACCTGCCCCAACGAG
CTTTTCCCCCAAGAGGGCGTAAGCGTGCCAGTGGTCAATGCAGTTGACGATGAAGCTGGCTATATCGCACAGAAATTTGG
CGAAAAATTTGGGCTTGATGGGGTTTATGCCTTTTCCTGTAATACAGCCTTTGCTCAATATGGCATTCGCTTGCAAGACG
ATGGGCGTAATTTGCTCGAAGATCAAGCGCGGCGTTTTCATATTTACCCCGCCGATGAATTGCCCGACACTGGCGATTTG
ACCGATTTGCCTTCAGCGCCCAGCCAACTCTATGGCGGCGAAGATGGCGATGAATGGTGGAGCCAGCCCGTGGCGATTGC
TGATACTGCCTATGGTCAAGGCCGCTTGTTGGTCACCCCACTCGAAATGGCGATGATCACCCAAGCCATCGGCAATAATG
GCGATATGATGAAGCCTTACTTGGTCGAACGGGTGACCACCCCGCAAGGCGGTGAGTTGTATCAAGCCCGCCCACGTAAA
ATCGGCGATCCGATGAGTGTCGAGGTTTCGCAACGCATTCGGATTTCGATGAAGGCGGTGGTTGAGCAGGGTTGGTCGGG
GGCGACGGTGGCTGGCGTGCCAGGTTATAGCGTTGGCGGCAAATCGGGCACAGCTGAAAATCCCCTTGGTGCGCCGCATG
CTTGGTTTATCTCGTTGGCTCCGCTGGACGATCCCAAATATGCAGTGGCTGTGATGGTTGAGAATGGCGGCGAAGGTACC
AGTGTTGGCGGCTCATTGGCAGGGATTGTCATGTCGGCAGCATTGGAAATCAATCCATAA

Upstream 100 bases:

>100_bases
ATTTTTGCCTTCTGCCTTTTGCCTTTCATCAGCCTTTCATTGCGACTCGCCCATTTAGCTTTATAATGACACTACGTTTT
GGTTACAGGAGAGCGGTCGC

Downstream 100 bases:

>100_bases
GCGTTTTTTTGAAGGATTTTTCATGGCTATCAATCAAGAGCGTCTGCTCGATACGTTTTGTACTTTGGTTCGGATCGATA
ATCCATCTGGTGAAGAAGCA

Product: penicillin-binding protein transpeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MQRFLKSLAGLIAVGLIIYGMVPWSKEEHWLPCLWIATILGGFAIWPIRTQRATGIYTATQNLALFMIIGFTMLTLQLLR
TQVIRADEIYNRVVAEDDGNIISNIRLVRSTNRIKRGAIFDSQGVTLAENVIVSDNRSYRTYPIANQYDMRAFGHTLGYV
SSIYGLYGLESSYNEYLAGGKGNSWQNLQNQLFSRPREGNNVQLTINAQLQDRAFKALDGRVGSVVVIDVKTGAIRAMVS
TPSFDPSQLTLRLDAEDYSAESDRVVNYWNSLISDESRPLVFRSTQGQYPPGSTFKTVTAIGVLNNPEVGKPEDITCPNE
LFPQEGVSVPVVNAVDDEAGYIAQKFGEKFGLDGVYAFSCNTAFAQYGIRLQDDGRNLLEDQARRFHIYPADELPDTGDL
TDLPSAPSQLYGGEDGDEWWSQPVAIADTAYGQGRLLVTPLEMAMITQAIGNNGDMMKPYLVERVTTPQGGELYQARPRK
IGDPMSVEVSQRIRISMKAVVEQGWSGATVAGVPGYSVGGKSGTAENPLGAPHAWFISLAPLDDPKYAVAVMVENGGEGT
SVGGSLAGIVMSAALEINP

Sequences:

>Translated_579_residues
MQRFLKSLAGLIAVGLIIYGMVPWSKEEHWLPCLWIATILGGFAIWPIRTQRATGIYTATQNLALFMIIGFTMLTLQLLR
TQVIRADEIYNRVVAEDDGNIISNIRLVRSTNRIKRGAIFDSQGVTLAENVIVSDNRSYRTYPIANQYDMRAFGHTLGYV
SSIYGLYGLESSYNEYLAGGKGNSWQNLQNQLFSRPREGNNVQLTINAQLQDRAFKALDGRVGSVVVIDVKTGAIRAMVS
TPSFDPSQLTLRLDAEDYSAESDRVVNYWNSLISDESRPLVFRSTQGQYPPGSTFKTVTAIGVLNNPEVGKPEDITCPNE
LFPQEGVSVPVVNAVDDEAGYIAQKFGEKFGLDGVYAFSCNTAFAQYGIRLQDDGRNLLEDQARRFHIYPADELPDTGDL
TDLPSAPSQLYGGEDGDEWWSQPVAIADTAYGQGRLLVTPLEMAMITQAIGNNGDMMKPYLVERVTTPQGGELYQARPRK
IGDPMSVEVSQRIRISMKAVVEQGWSGATVAGVPGYSVGGKSGTAENPLGAPHAWFISLAPLDDPKYAVAVMVENGGEGT
SVGGSLAGIVMSAALEINP
>Mature_579_residues
MQRFLKSLAGLIAVGLIIYGMVPWSKEEHWLPCLWIATILGGFAIWPIRTQRATGIYTATQNLALFMIIGFTMLTLQLLR
TQVIRADEIYNRVVAEDDGNIISNIRLVRSTNRIKRGAIFDSQGVTLAENVIVSDNRSYRTYPIANQYDMRAFGHTLGYV
SSIYGLYGLESSYNEYLAGGKGNSWQNLQNQLFSRPREGNNVQLTINAQLQDRAFKALDGRVGSVVVIDVKTGAIRAMVS
TPSFDPSQLTLRLDAEDYSAESDRVVNYWNSLISDESRPLVFRSTQGQYPPGSTFKTVTAIGVLNNPEVGKPEDITCPNE
LFPQEGVSVPVVNAVDDEAGYIAQKFGEKFGLDGVYAFSCNTAFAQYGIRLQDDGRNLLEDQARRFHIYPADELPDTGDL
TDLPSAPSQLYGGEDGDEWWSQPVAIADTAYGQGRLLVTPLEMAMITQAIGNNGDMMKPYLVERVTTPQGGELYQARPRK
IGDPMSVEVSQRIRISMKAVVEQGWSGATVAGVPGYSVGGKSGTAENPLGAPHAWFISLAPLDDPKYAVAVMVENGGEGT
SVGGSLAGIVMSAALEINP

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=495, Percent_Identity=24.8484848484848, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63211; Mature: 63211

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFLKSLAGLIAVGLIIYGMVPWSKEEHWLPCLWIATILGGFAIWPIRTQRATGIYTAT
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEEEC
QNLALFMIIGFTMLTLQLLRTQVIRADEIYNRVVAEDDGNIISNIRLVRSTNRIKRGAIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEECCCHHHCCCEE
DSQGVTLAENVIVSDNRSYRTYPIANQYDMRAFGHTLGYVSSIYGLYGLESSYNEYLAGG
CCCCCEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
KGNSWQNLQNQLFSRPREGNNVQLTINAQLQDRAFKALDGRVGSVVVIDVKTGAIRAMVS
CCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEEECCCEEEEEEE
TPSFDPSQLTLRLDAEDYSAESDRVVNYWNSLISDESRPLVFRSTQGQYPPGSTFKTVTA
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEE
IGVLNNPEVGKPEDITCPNELFPQEGVSVPVVNAVDDEAGYIAQKFGEKFGLDGVYAFSC
EEECCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEC
NTAFAQYGIRLQDDGRNLLEDQARRFHIYPADELPDTGDLTDLPSAPSQLYGGEDGDEWW
CHHHHHCCCEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCHHHH
SQPVAIADTAYGQGRLLVTPLEMAMITQAIGNNGDMMKPYLVERVTTPQGGELYQARPRK
CCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEECCCCC
IGDPMSVEVSQRIRISMKAVVEQGWSGATVAGVPGYSVGGKSGTAENPLGAPHAWFISLA
CCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEE
PLDDPKYAVAVMVENGGEGTSVGGSLAGIVMSAALEINP
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHEEECCC
>Mature Secondary Structure
MQRFLKSLAGLIAVGLIIYGMVPWSKEEHWLPCLWIATILGGFAIWPIRTQRATGIYTAT
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEEEC
QNLALFMIIGFTMLTLQLLRTQVIRADEIYNRVVAEDDGNIISNIRLVRSTNRIKRGAIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEECCCHHHCCCEE
DSQGVTLAENVIVSDNRSYRTYPIANQYDMRAFGHTLGYVSSIYGLYGLESSYNEYLAGG
CCCCCEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
KGNSWQNLQNQLFSRPREGNNVQLTINAQLQDRAFKALDGRVGSVVVIDVKTGAIRAMVS
CCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEEECCCEEEEEEE
TPSFDPSQLTLRLDAEDYSAESDRVVNYWNSLISDESRPLVFRSTQGQYPPGSTFKTVTA
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEE
IGVLNNPEVGKPEDITCPNELFPQEGVSVPVVNAVDDEAGYIAQKFGEKFGLDGVYAFSC
EEECCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEC
NTAFAQYGIRLQDDGRNLLEDQARRFHIYPADELPDTGDLTDLPSAPSQLYGGEDGDEWW
CHHHHHCCCEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCHHHH
SQPVAIADTAYGQGRLLVTPLEMAMITQAIGNNGDMMKPYLVERVTTPQGGELYQARPRK
CCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEECCCCC
IGDPMSVEVSQRIRISMKAVVEQGWSGATVAGVPGYSVGGKSGTAENPLGAPHAWFISLA
CCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEE
PLDDPKYAVAVMVENGGEGTSVGGSLAGIVMSAALEINP
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA