Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 159900309

GI number: 159900309

Start: 4762028

End: 4762483

Strand: Direct

Name: msrA [H]

Synonym: Haur_3792

Alternate gene names: 159900309

Gene position: 4762028-4762483 (Clockwise)

Preceding gene: 159900306

Following gene: 159900312

Centisome position: 75.03

GC content: 48.46

Gene sequence:

>456_bases
ATGATCGAACGAATTATTGTTGGTGCTGGGTGTTTTTGGGGAGTCGAAGCGGCTTTTGGGGCGCTTGCCGGTATTGTCCA
AACCCAAGCTGGCTACGCTGGTGGTTGGACTGAGCAGCCAAGCTATGAGGATGTTTGTGCAGGATCGACAGGTCATGCCG
AGGTCGTCGAATTACATGTTGATCTAACGATCATCAGTTTAAACGAGCTGTTGGGTTATTTTTGGGCTATGCTAGAACCG
CCAGCCGACCCCGACCCACAATATCGCGCAATGATTATTTGTAGCAATGCTGCTCAGTTGGAGCTAGCTCTGGCCAGTAA
GCTAGCTCAACCACAGCTCGTTGATTATTCTGTTGAAATAAAACTTGATCTGCCGTTTTACCCCGCCGAGGAATATCATC
AACAATGTTATCGCAAATGGCGTGATCGCTTTGAACGGCGGGCTAAAGTTGTTTGA

Upstream 100 bases:

>100_bases
ACGCCTAGAATTTTAAATTACTATCAGGCTGCACTGTTAATACTATCAATAATGCCCAAGCGATTGGGCAGTTTAGCTAA
TTTCGGCTAAGGTGTGCACA

Downstream 100 bases:

>100_bases
GCATATCTTGAATCAGTTCATGGTTGATGCCTGCGCCTGCCATCGCGCCACCAGCGGCGGCATTGATTGCTTGCTGCATG
CCTGCGGTCGCATCGCCAGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MIERIIVGAGCFWGVEAAFGALAGIVQTQAGYAGGWTEQPSYEDVCAGSTGHAEVVELHVDLTIISLNELLGYFWAMLEP
PADPDPQYRAMIICSNAAQLELALASKLAQPQLVDYSVEIKLDLPFYPAEEYHQQCYRKWRDRFERRAKVV

Sequences:

>Translated_151_residues
MIERIIVGAGCFWGVEAAFGALAGIVQTQAGYAGGWTEQPSYEDVCAGSTGHAEVVELHVDLTIISLNELLGYFWAMLEP
PADPDPQYRAMIICSNAAQLELALASKLAQPQLVDYSVEIKLDLPFYPAEEYHQQCYRKWRDRFERRAKVV
>Mature_151_residues
MIERIIVGAGCFWGVEAAFGALAGIVQTQAGYAGGWTEQPSYEDVCAGSTGHAEVVELHVDLTIISLNELLGYFWAMLEP
PADPDPQYRAMIICSNAAQLELALASKLAQPQLVDYSVEIKLDLPFYPAEEYHQQCYRKWRDRFERRAKVV

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=142, Percent_Identity=40.1408450704225, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI6912516, Length=146, Percent_Identity=39.7260273972603, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=39.7350993377483, Blast_Score=98, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=135, Percent_Identity=34.0740740740741, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=146, Percent_Identity=32.8767123287671, Blast_Score=67, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24664627, Length=138, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=138, Percent_Identity=38.4057971014493, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 16868; Mature: 16868

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERIIVGAGCFWGVEAAFGALAGIVQTQAGYAGGWTEQPSYEDVCAGSTGHAEVVELHV
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEE
DLTIISLNELLGYFWAMLEPPADPDPQYRAMIICSNAAQLELALASKLAQPQLVDYSVEI
EEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEE
KLDLPFYPAEEYHQQCYRKWRDRFERRAKVV
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIERIIVGAGCFWGVEAAFGALAGIVQTQAGYAGGWTEQPSYEDVCAGSTGHAEVVELHV
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEE
DLTIISLNELLGYFWAMLEPPADPDPQYRAMIICSNAAQLELALASKLAQPQLVDYSVEI
EEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEE
KLDLPFYPAEEYHQQCYRKWRDRFERRAKVV
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA