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The map label for this gene is norM [H]

Identifier: 159900209

GI number: 159900209

Start: 4644463

End: 4645848

Strand: Direct

Name: norM [H]

Synonym: Haur_3692

Alternate gene names: 159900209

Gene position: 4644463-4645848 (Clockwise)

Preceding gene: 159900205

Following gene: 159900210

Centisome position: 73.18

GC content: 51.88

Gene sequence:

>1386_bases
ATGGCAATTCCATTAGGCGCAGCACAGGGGCGAAGCAGCCAACGGAGTGCTGTATTAAAGTTGGGCTTGCCAGCAGTTGG
CGAGCAATTATTGAGTTTGATGGTTGGGTTGGTTGATACCTATGTGGTGGGACACTTGAGCTTAGCCGTCGCAACTGCCA
ATGGCTACGATCGCCAAATCGCCTTGGCAGCGACCGGCATTTCGAGCCAAGTCACATGGACATTAATCACCTTTTTTATG
GCAGTAGCCCTCGGTAGCACGGTGGTTATTGCGCGGTTTGTGGGGGCAGGCGAGCGCGAACAAGCCAACCAAACCCTGCG
CCAAGCCCTGCTAATTGGGCTAGCCATGGGCCTGCTGAGTTTATTTTTGGCCTATAGCTTTGCCCCTCAACTGATGGATT
TACTCGGCGCAAACGAGCAAGTGCGCCAATATGGGGCTGGCTATTTGCGTATTTCCGCCTTATCAATGCCCTTAATGGCC
ATGCTTTACGTGGGCAATGCCGCCTTACGTGGCTCCGGCGATACGCGCACCCCACTCAAGGTTATGCTGGTCGTCAATGG
GATCAACGCAGGGTTATCGTTGCTCTTGGTCAATGGCTATTTTGGTTTTCCGGCGATGGGGATTAATGGGGCAGCATTTG
CCGCGATGAGTGGGCAAGGCATCGGTGGCTTAATGGTGCTTGCAACACTGATTCGTGGCCGTTCAGGCTTGAAGCTTGAT
CAAATTCCACGCCCAGATGGCAATTTGATCTGGCGGATTTTACGCCAAGGGCTGCCATATGGGGCTGAGCAATTTATTTT
TCAGGCCGCATTATTAATTTTTATCCATTTGATCAACGATATTGGCACGGCGGCTTATGCTGCGCATAACACCATTATCA
CGATTGAAAGTATTTCGTTTTTGCCAGGCATGGGCTTGGCGGTAGCCGCCACAACCTTAGTCGGCCAACATATGGGAGCA
AATCAGCCACAACAAGCTAGCGAAAGTGGCTTTGAGGCATTTCGGCTGGGAGCACTCTTCATGGGGGCAATTGGCTTATT
GTTTGTAGTTGCGCCAGAAGTCTTTTTGCGCTTTTTCGTTGCTGACGAAGAGGTAGTGCAACTCGCCGCCTTACCGTTGC
GCATGGTTGGGTTTGCTCAGCCCGCTTTGGCCGCTAATTTCATCTTCAGCGGCAGTTTACGTGGTGGTGGCGAGCCAAAA
TGGCCACTGATTAGCAAAATGCTGAGTGTTTGGTGTGTCCGCTTACCGCTGGCATGGCTGCTTGTCAAGCACTTCGACCT
TGGCTTGAATGGCATTTGGCTGGCAATGTGTACCGATTTTGCCGTCCAAGGCAGCTTGGCATGGTGGCGCTTCCGACAAG
GCAAATGGCAAAGTGCAAAAGTTTAG

Upstream 100 bases:

>100_bases
TTGGCTTTGAATTTCATCCCGCATCCCGCATCCTTCATACTTTGCACGACTTCTGCTATTATGCATATATCGACATATTG
CATGAGGTAACGGACGCATC

Downstream 100 bases:

>100_bases
CATTGGGGAGCAATGGTTGAGGTTGGAGCAGGGTCGGGTTTAAGACCCCTCACCTCCGACCCCTCTCCCACGGCGGCGGG
CGAGGGGGTCAGGGGGTGAG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAIPLGAAQGRSSQRSAVLKLGLPAVGEQLLSLMVGLVDTYVVGHLSLAVATANGYDRQIALAATGISSQVTWTLITFFM
AVALGSTVVIARFVGAGEREQANQTLRQALLIGLAMGLLSLFLAYSFAPQLMDLLGANEQVRQYGAGYLRISALSMPLMA
MLYVGNAALRGSGDTRTPLKVMLVVNGINAGLSLLLVNGYFGFPAMGINGAAFAAMSGQGIGGLMVLATLIRGRSGLKLD
QIPRPDGNLIWRILRQGLPYGAEQFIFQAALLIFIHLINDIGTAAYAAHNTIITIESISFLPGMGLAVAATTLVGQHMGA
NQPQQASESGFEAFRLGALFMGAIGLLFVVAPEVFLRFFVADEEVVQLAALPLRMVGFAQPALAANFIFSGSLRGGGEPK
WPLISKMLSVWCVRLPLAWLLVKHFDLGLNGIWLAMCTDFAVQGSLAWWRFRQGKWQSAKV

Sequences:

>Translated_461_residues
MAIPLGAAQGRSSQRSAVLKLGLPAVGEQLLSLMVGLVDTYVVGHLSLAVATANGYDRQIALAATGISSQVTWTLITFFM
AVALGSTVVIARFVGAGEREQANQTLRQALLIGLAMGLLSLFLAYSFAPQLMDLLGANEQVRQYGAGYLRISALSMPLMA
MLYVGNAALRGSGDTRTPLKVMLVVNGINAGLSLLLVNGYFGFPAMGINGAAFAAMSGQGIGGLMVLATLIRGRSGLKLD
QIPRPDGNLIWRILRQGLPYGAEQFIFQAALLIFIHLINDIGTAAYAAHNTIITIESISFLPGMGLAVAATTLVGQHMGA
NQPQQASESGFEAFRLGALFMGAIGLLFVVAPEVFLRFFVADEEVVQLAALPLRMVGFAQPALAANFIFSGSLRGGGEPK
WPLISKMLSVWCVRLPLAWLLVKHFDLGLNGIWLAMCTDFAVQGSLAWWRFRQGKWQSAKV
>Mature_460_residues
AIPLGAAQGRSSQRSAVLKLGLPAVGEQLLSLMVGLVDTYVVGHLSLAVATANGYDRQIALAATGISSQVTWTLITFFMA
VALGSTVVIARFVGAGEREQANQTLRQALLIGLAMGLLSLFLAYSFAPQLMDLLGANEQVRQYGAGYLRISALSMPLMAM
LYVGNAALRGSGDTRTPLKVMLVVNGINAGLSLLLVNGYFGFPAMGINGAAFAAMSGQGIGGLMVLATLIRGRSGLKLDQ
IPRPDGNLIWRILRQGLPYGAEQFIFQAALLIFIHLINDIGTAAYAAHNTIITIESISFLPGMGLAVAATTLVGQHMGAN
QPQQASESGFEAFRLGALFMGAIGLLFVVAPEVFLRFFVADEEVVQLAALPLRMVGFAQPALAANFIFSGSLRGGGEPKW
PLISKMLSVWCVRLPLAWLLVKHFDLGLNGIWLAMCTDFAVQGSLAWWRFRQGKWQSAKV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=445, Percent_Identity=27.1910112359551, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI48994890, Length=416, Percent_Identity=22.1153846153846, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49130; Mature: 48998

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPLGAAQGRSSQRSAVLKLGLPAVGEQLLSLMVGLVDTYVVGHLSLAVATANGYDRQI
CCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
ALAATGISSQVTWTLITFFMAVALGSTVVIARFVGAGEREQANQTLRQALLIGLAMGLLS
EEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LFLAYSFAPQLMDLLGANEQVRQYGAGYLRISALSMPLMAMLYVGNAALRGSGDTRTPLK
HHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCEE
VMLVVNGINAGLSLLLVNGYFGFPAMGINGAAFAAMSGQGIGGLMVLATLIRGRSGLKLD
EEEEEECCCCCEEEEEEECCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCCCCCCCCC
QIPRPDGNLIWRILRQGLPYGAEQFIFQAALLIFIHLINDIGTAAYAAHNTIITIESISF
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
LPGMGLAVAATTLVGQHMGANQPQQASESGFEAFRLGALFMGAIGLLFVVAPEVFLRFFV
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEEVVQLAALPLRMVGFAQPALAANFIFSGSLRGGGEPKWPLISKMLSVWCVRLPLAWL
CCHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVKHFDLGLNGIWLAMCTDFAVQGSLAWWRFRQGKWQSAKV
HHHHHCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCCCCC
>Mature Secondary Structure 
AIPLGAAQGRSSQRSAVLKLGLPAVGEQLLSLMVGLVDTYVVGHLSLAVATANGYDRQI
CCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
ALAATGISSQVTWTLITFFMAVALGSTVVIARFVGAGEREQANQTLRQALLIGLAMGLLS
EEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LFLAYSFAPQLMDLLGANEQVRQYGAGYLRISALSMPLMAMLYVGNAALRGSGDTRTPLK
HHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCEE
VMLVVNGINAGLSLLLVNGYFGFPAMGINGAAFAAMSGQGIGGLMVLATLIRGRSGLKLD
EEEEEECCCCCEEEEEEECCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCCCCCCCCC
QIPRPDGNLIWRILRQGLPYGAEQFIFQAALLIFIHLINDIGTAAYAAHNTIITIESISF
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
LPGMGLAVAATTLVGQHMGANQPQQASESGFEAFRLGALFMGAIGLLFVVAPEVFLRFFV
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEEVVQLAALPLRMVGFAQPALAANFIFSGSLRGGGEPKWPLISKMLSVWCVRLPLAWL
CCHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVKHFDLGLNGIWLAMCTDFAVQGSLAWWRFRQGKWQSAKV
HHHHHCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]