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The map label for this gene is comEC [H]

Identifier: 159900163

GI number: 159900163

Start: 4585983

End: 4587464

Strand: Direct

Name: comEC [H]

Synonym: Haur_3646

Alternate gene names: 159900163

Gene position: 4585983-4587464 (Clockwise)

Preceding gene: 159900160

Following gene: 159900164

Centisome position: 72.26

GC content: 50.54

Gene sequence:

>1482_bases
ATGCGACTTTGTGGTTTTACTGCTGGCTGGCTGCTTGGGCTGTGGTTAAATGATAGGCTACAAATAGCATGGTATCTATA
TTTTATGGCATCAATAGCGATTATTTTACTCATTATCTATATCCGAAAATCATGGCGGGTTATGCTGATAGCAATATATG
CTGGTACTATGCTAGGGGTAGTACGAATGGCGGTCAGTCAAAATTCCTCAAATCTTGACGATATTCGTCAACAGATTGGC
ATGACAACTCGTTTAGAAGGAGTAATTGTCGGCCAGCCGCAATGGACTCCACAGCAACAACGGGTGGTTTTAGCCGTCCA
TGCTTATCAAGATAATCAGCAACGAGTTGCCACAACTGGCAAGATTATGTTAACTCTTCCAGCCGAGCCACCACGCAGTA
ATGGCGAACGTTTGTTAGTCAGCGGCACAATCATCACGCCAACCGCTAGCCCAAATTTCGATTATGCCGACTATCTACGT
CGCCGCTCGATTTATGCCATGCTTGAGCCTGCAACCGTTGAACAAGCCTTGCCTGCAAAAAATTCAGTCTATCAACGCTT
AATCGCGCTCAAACAGCGCTCGCAAACAATCATCAACCAAACGTTGCCGCAACCGCAAGCAGCAGTTTTGGTCGGAATGT
TGCTGGGAGTCAAAAGCAGCGTGCCTCAAACTGTGTGGGATACCTTCAATCGCACTGGGCTTTCGCATATCTTAATCATC
TCAGGCTGGAATATTACAATTGTGGTGGCGGCGTTATTGGGTTTGGGCAAGGCCTTAAAGCTTAGTCAACGCCACGCCAC
CATGGTGGCAATTGGCGCAATTGTGGTGTATGTAGCCTTTGTGGGAGCTAGCGGGGCTGTGATTCGCGCTGCCTTGATGG
GCGCAATCGTGGCACTAGCCCAGCCGCTTGGTCGCAAATCCGATGCTTGGGCGGCACTCGCGGCAGCAACTTGGCTCATG
ACCCTGATCGATCCGCACACCTTATGGGATTTAGGCTTTCAACTATCAGCTTTGGCCACGGCGAGCTTGTTTGCTTGGGG
CAAGCCAATTGAAGCTCAATTGCGGCAGTGGCTGCGTTGGCGCTGGCTCGAATGGATGATCGAGCCATTGACCGCAACAT
TGGCCGCCCAAATTTGGACACTGCCGATCATTCTGTATCATTTTGGTAATCTCTCGTTGATTGCACCCGTCGCCAATGTA
CTGATTGTGCCAGTTGTGCCGTTGATTATGGCCAGCGGCGCAATGCTAGCATGCTTGGGGTTGTTTGGCCGTTGGTTAGC
ATTGCTGGCCTTGCCAATCACATGGGCGGCATTAACTTGGGTCGTTGAGGCCGCCGAATGGCTGGCCGATTTATCTTGGG
CAGCGGTCGAAATTCCTAGGTTTGGCATGAGCTGGCTGGTGCTGGCGTATGGCTTGAGCGTTGGGGCGAAGGCGTGGATG
GTTAACCACGAAGAACGCGAAGGACGCGAAGTAAGAATTTAA

Upstream 100 bases:

>100_bases
TATTTTACTATTTTTCACCACCATCCAGTGGCAATAGTGACATGGGGGATTTTTAGGGGATTGCGGCTCTAAAAAACCAG
CATTATTGAGGAGTTTGCAT

Downstream 100 bases:

>100_bases
CGCAGAGGCAAAGAGAGGGCTAGGGGCCAAGAAACATAGTGGTAAACCAGAAAACAACTTAGAGCTAGCAGAAAATCAAA
CAAATCAGGGGCTAAAAATG

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MRLCGFTAGWLLGLWLNDRLQIAWYLYFMASIAIILLIIYIRKSWRVMLIAIYAGTMLGVVRMAVSQNSSNLDDIRQQIG
MTTRLEGVIVGQPQWTPQQQRVVLAVHAYQDNQQRVATTGKIMLTLPAEPPRSNGERLLVSGTIITPTASPNFDYADYLR
RRSIYAMLEPATVEQALPAKNSVYQRLIALKQRSQTIINQTLPQPQAAVLVGMLLGVKSSVPQTVWDTFNRTGLSHILII
SGWNITIVVAALLGLGKALKLSQRHATMVAIGAIVVYVAFVGASGAVIRAALMGAIVALAQPLGRKSDAWAALAAATWLM
TLIDPHTLWDLGFQLSALATASLFAWGKPIEAQLRQWLRWRWLEWMIEPLTATLAAQIWTLPIILYHFGNLSLIAPVANV
LIVPVVPLIMASGAMLACLGLFGRWLALLALPITWAALTWVVEAAEWLADLSWAAVEIPRFGMSWLVLAYGLSVGAKAWM
VNHEEREGREVRI

Sequences:

>Translated_493_residues
MRLCGFTAGWLLGLWLNDRLQIAWYLYFMASIAIILLIIYIRKSWRVMLIAIYAGTMLGVVRMAVSQNSSNLDDIRQQIG
MTTRLEGVIVGQPQWTPQQQRVVLAVHAYQDNQQRVATTGKIMLTLPAEPPRSNGERLLVSGTIITPTASPNFDYADYLR
RRSIYAMLEPATVEQALPAKNSVYQRLIALKQRSQTIINQTLPQPQAAVLVGMLLGVKSSVPQTVWDTFNRTGLSHILII
SGWNITIVVAALLGLGKALKLSQRHATMVAIGAIVVYVAFVGASGAVIRAALMGAIVALAQPLGRKSDAWAALAAATWLM
TLIDPHTLWDLGFQLSALATASLFAWGKPIEAQLRQWLRWRWLEWMIEPLTATLAAQIWTLPIILYHFGNLSLIAPVANV
LIVPVVPLIMASGAMLACLGLFGRWLALLALPITWAALTWVVEAAEWLADLSWAAVEIPRFGMSWLVLAYGLSVGAKAWM
VNHEEREGREVRI
>Mature_493_residues
MRLCGFTAGWLLGLWLNDRLQIAWYLYFMASIAIILLIIYIRKSWRVMLIAIYAGTMLGVVRMAVSQNSSNLDDIRQQIG
MTTRLEGVIVGQPQWTPQQQRVVLAVHAYQDNQQRVATTGKIMLTLPAEPPRSNGERLLVSGTIITPTASPNFDYADYLR
RRSIYAMLEPATVEQALPAKNSVYQRLIALKQRSQTIINQTLPQPQAAVLVGMLLGVKSSVPQTVWDTFNRTGLSHILII
SGWNITIVVAALLGLGKALKLSQRHATMVAIGAIVVYVAFVGASGAVIRAALMGAIVALAQPLGRKSDAWAALAAATWLM
TLIDPHTLWDLGFQLSALATASLFAWGKPIEAQLRQWLRWRWLEWMIEPLTATLAAQIWTLPIILYHFGNLSLIAPVANV
LIVPVVPLIMASGAMLACLGLFGRWLALLALPITWAALTWVVEAAEWLADLSWAAVEIPRFGMSWLVLAYGLSVGAKAWM
VNHEEREGREVRI

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 54454; Mature: 54454

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLCGFTAGWLLGLWLNDRLQIAWYLYFMASIAIILLIIYIRKSWRVMLIAIYAGTMLGV
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VRMAVSQNSSNLDDIRQQIGMTTRLEGVIVGQPQWTPQQQRVVLAVHAYQDNQQRVATTG
HHHHHHCCCCCHHHHHHHHCCCEEECEEEECCCCCCCCCCEEEEEEEECCCCCHHEEECC
KIMLTLPAEPPRSNGERLLVSGTIITPTASPNFDYADYLRRRSIYAMLEPATVEQALPAK
EEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHEECCHHHHHHCCCH
NSVYQRLIALKQRSQTIINQTLPQPQAAVLVGMLLGVKSSVPQTVWDTFNRTGLSHILII
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEE
SGWNITIVVAALLGLGKALKLSQRHATMVAIGAIVVYVAFVGASGAVIRAALMGAIVALA
ECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QPLGRKSDAWAALAAATWLMTLIDPHTLWDLGFQLSALATASLFAWGKPIEAQLRQWLRW
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RWLEWMIEPLTATLAAQIWTLPIILYHFGNLSLIAPVANVLIVPVVPLIMASGAMLACLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LFGRWLALLALPITWAALTWVVEAAEWLADLSWAAVEIPRFGMSWLVLAYGLSVGAKAWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCHHHHHHHHHHHCCCCEEE
VNHEEREGREVRI
ECCHHCCCCCCCC
>Mature Secondary Structure
MRLCGFTAGWLLGLWLNDRLQIAWYLYFMASIAIILLIIYIRKSWRVMLIAIYAGTMLGV
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VRMAVSQNSSNLDDIRQQIGMTTRLEGVIVGQPQWTPQQQRVVLAVHAYQDNQQRVATTG
HHHHHHCCCCCHHHHHHHHCCCEEECEEEECCCCCCCCCCEEEEEEEECCCCCHHEEECC
KIMLTLPAEPPRSNGERLLVSGTIITPTASPNFDYADYLRRRSIYAMLEPATVEQALPAK
EEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHEECCHHHHHHCCCH
NSVYQRLIALKQRSQTIINQTLPQPQAAVLVGMLLGVKSSVPQTVWDTFNRTGLSHILII
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEE
SGWNITIVVAALLGLGKALKLSQRHATMVAIGAIVVYVAFVGASGAVIRAALMGAIVALA
ECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QPLGRKSDAWAALAAATWLMTLIDPHTLWDLGFQLSALATASLFAWGKPIEAQLRQWLRW
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RWLEWMIEPLTATLAAQIWTLPIILYHFGNLSLIAPVANVLIVPVVPLIMASGAMLACLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LFGRWLALLALPITWAALTWVVEAAEWLADLSWAAVEIPRFGMSWLVLAYGLSVGAKAWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCHHHHHHHHHHHCCCCEEE
VNHEEREGREVRI
ECCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]