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The map label for this gene is 159899783

Identifier: 159899783

GI number: 159899783

Start: 4126663

End: 4128414

Strand: Reverse

Name: 159899783

Synonym: Haur_3265

Alternate gene names: NA

Gene position: 4128414-4126663 (Counterclockwise)

Preceding gene: 159899784

Following gene: 159899782

Centisome position: 65.05

GC content: 52.8

Gene sequence:

>1752_bases
TTGAAGCGTCTGTTTGTTTCATTCGTCTTGATCTGCAGTCTTGTCATTATCTTCAGTGCTCCCAACCCATCATTTGGTCA
AAGCCGAACTCCTGCGAAACCAGTTGATCGCGTTGATTTTGCTGCTCCAGCAGTAGCGGGCCAATTTGTGGTCAAATTCA
AAGCCACAACCAGCAAAGCCAACCGCAGCTCGGCCCTCAAAGCCCTCGGCGCGGTACAAATCGATCGCATTGCAGCGCTT
GATGCAGAAGTGATCGAAGTTGCGAGCCTCAAGAGCAACGATACCCTCGCAGGTCGCGAAGCTGTCTTGGCTGGCTTGAA
GCAAAATCCCAATGTCGAATATGCCGAACCCAACTTTATTTATAATGTGAATTTTACGCCCAATGACCCAAGCCAAAGCT
CACAATGGGCATGGGGTGTCATCCGTGCATATACCGGTTGGGATATAACCCAAGGCAGCAGCAGCGTGGTGATTGCAGTT
GTTGATACAGGGGTTCAAGGCACCCACCCTGATCTTGATGCCAAGATGGTGGCTGGCTACGACTATATCGACAACGACTC
AACGCCAACCGACGGCAATGGCCACGGTACCCACGTTGCAGGTACAAGCGCCGCTGAAACGAATAACAGCACTGGTGGTG
CTGGCACATGTCCAAATTGTAAGGTGATGCCAGTGCGGGTATTGGGCAACGATGGTAGTGGGACGTTGGCTGGTGTGGCC
AATGGGATCACCTACGCTGCCGACAATGGCGCAAAAGTCATCAATTTGAGCCTTGGTGGTGGTGGTTCGACCGCATTGCA
AAATGCTGTTGACTACGCTTGGGGCCGTGGGGTGTTCTTGGCTTGTGCTGCTGGTAATAGCAACACCTCAAGCACCACCA
GCTCGTATCCAGCTGCTTACACCAACTGTTTTGCGATCGCCTCAACCACCTCAAGCGATGCTCGTTCATCGTTCTCGAAC
TACGGTTCGTGGGTTGAAGTGGCTGCCCCAGGTTCGAGCATCTACTCAACTTGGATCAACAGTGGCTACAACACGATCAA
TGGTACTTCAATGGCTACCCCACACGTTGCTGGTTTGGCTGGCTTGTTGGCCTCACAAGGCTTGACCAATAGCCAAATTC
GCGACCGCATCTGCTCGACCTCAGATCGCATCACGGGCACAGGCAGCACTTGGACTTGTGGTCGGATCAACGTCTACAAT
GCTGTCAACAACGGTGGCTCAACCCCAACCCCAACGCCTCCAACCAGCACGCCAAATCCAACCACCCCAACCGTGGTTCC
ACCAACCGCAACCCCACCTCCAGGCGGCGGTAGCATTGTCAATGGTGGCTTCGAAAGTGGCACAACTGGCTGGACCCAAG
CCTCAAGCGGTGGTTATAACGTAATTGATACCACTCGCCCACGCACTGGTAGCTACAGCGTTTACATGGGTGGCTACAAC
AATGCCAGCGAAGGGATCTACCAAACGTTGACCGTGCCAGCAGGCAAGTCATTGAGCTTCTACTGGTATCAAACCACTGC
CGAAGGCAGCACGACAGCTTACGACTACCTGCGCGTTCGGGTCTACAACACCAGCGGAACCTTATTGGGAACCTTGGCTA
CTCGCTCGAATGTCAACACCAAGAACGCTTGGGTGGCTGAAAGCTTGAGCTTGGCAGCCTATGCTGGTCAAACGGTTCGT
ATCCGCTTTGAAACCACAACAGATAGCTCATTGATCACATCGTTCTTTGTTGACGATGTAAGCCTTCAATAA

Upstream 100 bases:

>100_bases
ATTCCTTCGAAACAATGATGTGTACGTGCGGTAATCCAACCACTGTCGGTTTTGGGATTGCCCATGGTAAATTTGCAATC
CACATATTGAGGAGGCACCC

Downstream 100 bases:

>100_bases
GCTGCTCGTTCTTCCTTAGTTTGCAATCGAACAACGTCAGTCACACCCGTCAACAGCAATGTTGGCGGGTGTGGCGTTTT
ACAAGCGCCTTGCGTTACGC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MKRLFVSFVLICSLVIIFSAPNPSFGQSRTPAKPVDRVDFAAPAVAGQFVVKFKATTSKANRSSALKALGAVQIDRIAAL
DAEVIEVASLKSNDTLAGREAVLAGLKQNPNVEYAEPNFIYNVNFTPNDPSQSSQWAWGVIRAYTGWDITQGSSSVVIAV
VDTGVQGTHPDLDAKMVAGYDYIDNDSTPTDGNGHGTHVAGTSAAETNNSTGGAGTCPNCKVMPVRVLGNDGSGTLAGVA
NGITYAADNGAKVINLSLGGGGSTALQNAVDYAWGRGVFLACAAGNSNTSSTTSSYPAAYTNCFAIASTTSSDARSSFSN
YGSWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLASQGLTNSQIRDRICSTSDRITGTGSTWTCGRINVYN
AVNNGGSTPTPTPPTSTPNPTTPTVVPPTATPPPGGGSIVNGGFESGTTGWTQASSGGYNVIDTTRPRTGSYSVYMGGYN
NASEGIYQTLTVPAGKSLSFYWYQTTAEGSTTAYDYLRVRVYNTSGTLLGTLATRSNVNTKNAWVAESLSLAAYAGQTVR
IRFETTTDSSLITSFFVDDVSLQ

Sequences:

>Translated_583_residues
MKRLFVSFVLICSLVIIFSAPNPSFGQSRTPAKPVDRVDFAAPAVAGQFVVKFKATTSKANRSSALKALGAVQIDRIAAL
DAEVIEVASLKSNDTLAGREAVLAGLKQNPNVEYAEPNFIYNVNFTPNDPSQSSQWAWGVIRAYTGWDITQGSSSVVIAV
VDTGVQGTHPDLDAKMVAGYDYIDNDSTPTDGNGHGTHVAGTSAAETNNSTGGAGTCPNCKVMPVRVLGNDGSGTLAGVA
NGITYAADNGAKVINLSLGGGGSTALQNAVDYAWGRGVFLACAAGNSNTSSTTSSYPAAYTNCFAIASTTSSDARSSFSN
YGSWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLASQGLTNSQIRDRICSTSDRITGTGSTWTCGRINVYN
AVNNGGSTPTPTPPTSTPNPTTPTVVPPTATPPPGGGSIVNGGFESGTTGWTQASSGGYNVIDTTRPRTGSYSVYMGGYN
NASEGIYQTLTVPAGKSLSFYWYQTTAEGSTTAYDYLRVRVYNTSGTLLGTLATRSNVNTKNAWVAESLSLAAYAGQTVR
IRFETTTDSSLITSFFVDDVSLQ
>Mature_583_residues
MKRLFVSFVLICSLVIIFSAPNPSFGQSRTPAKPVDRVDFAAPAVAGQFVVKFKATTSKANRSSALKALGAVQIDRIAAL
DAEVIEVASLKSNDTLAGREAVLAGLKQNPNVEYAEPNFIYNVNFTPNDPSQSSQWAWGVIRAYTGWDITQGSSSVVIAV
VDTGVQGTHPDLDAKMVAGYDYIDNDSTPTDGNGHGTHVAGTSAAETNNSTGGAGTCPNCKVMPVRVLGNDGSGTLAGVA
NGITYAADNGAKVINLSLGGGGSTALQNAVDYAWGRGVFLACAAGNSNTSSTTSSYPAAYTNCFAIASTTSSDARSSFSN
YGSWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLASQGLTNSQIRDRICSTSDRITGTGSTWTCGRINVYN
AVNNGGSTPTPTPPTSTPNPTTPTVVPPTATPPPGGGSIVNGGFESGTTGWTQASSGGYNVIDTTRPRTGSYSVYMGGYN
NASEGIYQTLTVPAGKSLSFYWYQTTAEGSTTAYDYLRVRVYNTSGTLLGTLATRSNVNTKNAWVAESLSLAAYAGQTVR
IRFETTTDSSLITSFFVDDVSLQ

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=428, Percent_Identity=22.4299065420561, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320775, Length=285, Percent_Identity=37.1929824561403, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324576, Length=291, Percent_Identity=31.6151202749141, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319893, Length=277, Percent_Identity=31.4079422382672, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 60540; Mature: 60540

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLFVSFVLICSLVIIFSAPNPSFGQSRTPAKPVDRVDFAAPAVAGQFVVKFKATTSKA
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCCC
NRSSALKALGAVQIDRIAALDAEVIEVASLKSNDTLAGREAVLAGLKQNPNVEYAEPNFI
CHHHHHHHHCCCEEHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECCCCEE
YNVNFTPNDPSQSSQWAWGVIRAYTGWDITQGSSSVVIAVVDTGVQGTHPDLDAKMVAGY
EEEEECCCCCCCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCCCEEEECC
DYIDNDSTPTDGNGHGTHVAGTSAAETNNSTGGAGTCPNCKVMPVRVLGNDGSGTLAGVA
EEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECC
NGITYAADNGAKVINLSLGGGGSTALQNAVDYAWGRGVFLACAAGNSNTSSTTSSYPAAY
CCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHH
TNCFAIASTTSSDARSSFSNYGSWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLA
HEEEEEEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GLLASQGLTNSQIRDRICSTSDRITGTGSTWTCGRINVYNAVNNGGSTPTPTPPTSTPNP
HHHHHCCCCHHHHHHHHHCCCCCEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCCCCC
TTPTVVPPTATPPPGGGSIVNGGFESGTTGWTQASSGGYNVIDTTRPRTGSYSVYMGGYN
CCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCC
NASEGIYQTLTVPAGKSLSFYWYQTTAEGSTTAYDYLRVRVYNTSGTLLGTLATRSNVNT
CCCCCEEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCC
KNAWVAESLSLAAYAGQTVRIRFETTTDSSLITSFFVDDVSLQ
CCCCHHHHCEEEEECCCEEEEEEECCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRLFVSFVLICSLVIIFSAPNPSFGQSRTPAKPVDRVDFAAPAVAGQFVVKFKATTSKA
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCCC
NRSSALKALGAVQIDRIAALDAEVIEVASLKSNDTLAGREAVLAGLKQNPNVEYAEPNFI
CHHHHHHHHCCCEEHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECCCCEE
YNVNFTPNDPSQSSQWAWGVIRAYTGWDITQGSSSVVIAVVDTGVQGTHPDLDAKMVAGY
EEEEECCCCCCCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCCCEEEECC
DYIDNDSTPTDGNGHGTHVAGTSAAETNNSTGGAGTCPNCKVMPVRVLGNDGSGTLAGVA
EEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECC
NGITYAADNGAKVINLSLGGGGSTALQNAVDYAWGRGVFLACAAGNSNTSSTTSSYPAAY
CCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHH
TNCFAIASTTSSDARSSFSNYGSWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLA
HEEEEEEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GLLASQGLTNSQIRDRICSTSDRITGTGSTWTCGRINVYNAVNNGGSTPTPTPPTSTPNP
HHHHHCCCCHHHHHHHHHCCCCCEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCCCCC
TTPTVVPPTATPPPGGGSIVNGGFESGTTGWTQASSGGYNVIDTTRPRTGSYSVYMGGYN
CCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCC
NASEGIYQTLTVPAGKSLSFYWYQTTAEGSTTAYDYLRVRVYNTSGTLLGTLATRSNVNT
CCCCCEEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCC
KNAWVAESLSLAAYAGQTVRIRFETTTDSSLITSFFVDDVSLQ
CCCCHHHHCEEEEECCCEEEEEEECCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]