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The map label for this gene is nuoL [H]

Identifier: 159899731

GI number: 159899731

Start: 4062908

End: 4064959

Strand: Reverse

Name: nuoL [H]

Synonym: Haur_3213

Alternate gene names: 159899731

Gene position: 4064959-4062908 (Counterclockwise)

Preceding gene: 159899732

Following gene: 159899730

Centisome position: 64.05

GC content: 52.1

Gene sequence:

>2052_bases
ATGGCGGAATTAATTTGGCTTGTGCCGTTGCTGCCACTGCTCGGTGTCGTGATCAATACCCTGTTGGGGCTGAACGATTT
GCGTCTCAGCCGCGCCAACGCCCACCACGACCATGGGCATGATCACGGGCATGGCCACGGTGACGCGCACCATGGACATG
GCGATAATCCCACCGCTAAACGCTCTGGCTTGATTGCCAGCGTCATGGTTGGTTTGGGCTTTGTGCTGACCGTCGCAACC
CTCATCGAGTTGCTGGGCATGCCTGCCAAAACCACATTGGGCGAAAATAATCGTTGGTTCGATGTAACCTATTGGAACTG
GATGGCCTTTGGCGATTTGGAAGTTCCTTTTGGTTTCTTAATCGACCAGCTTTCGGTCACGATGATGCTCTTGGTCACTG
GCGTAGGGACGTTGATTCACCTCTATGCAGTGGGCTATATGAGCCACGACGAACGCCCCACCCGCTTTTTTGTCTACCTC
AACTTATTTATTGTGGCAATGTTGATGCTCGTCATGGGCAACAACTTTGTGATGCTGTTCTTAGGTTGGGAAGGCGTGGG
CTTGTGTTCGTTCTTGTTGATTGGCTTCTGGTTTGAACAACGCGACCCACCATGGGCTTCAGTCAAAGCTTTTGTAACCA
ACCGGGTTGGCGACTTTGGCTTGTTGATGGCGATGTTTGCAATTTGGGCCTTGGCGCGTAAGCCCGATGGCACTTTCTTG
CATTCGTTGGTCTTCCGCGAAGTCTTGGAACAAGGCACGGTCTTCTCGCTGCAACAATACAGCACCTTCTTTATGGGTAC
GCAATACACGGCGGCTGGGGCGATTGCCTTTATGCTGTTGCTTGGCGTAACTGGGAAATCGGCGCAAATTCCGCTGTTTG
TCTGGTTGCCCGATGCAATGGCTGGCCCAACTCCTGTTTCGGCCTTGATTCACGCCGCAACCATGGTTACCGCTGGCGTG
TATTTGATGATCCGCACCCATCCAATCTTTGAATTATCGCCAGCGGTTCAAAGCAGCGTAACCTTTATTGGGGTTGCGAC
CGCTTTGGTCGCTGCTTCAATTGCGCTCGGTCAATACGATATCAAGAAGGTTCTGGCCTTCTCGACCGTCTCGCAATTGG
GCTTTATGGTGGCAGCCGTAGGTATGGGAGCATACGTTGCCGCGATGTTCCACCTGCTGACCCACGGGATTTTCAAGGCG
CTCTTGTTCCTTGGCTCTGGTTCAGTGATTCACGGCTTTGGCAACGAACAAGATATGCGCAAGATGGGCGGTCTGCGCAA
GAAAATGCCTGTTACGTTCTGGACATATATTGTCGGGACGATGGGCTTGATCGGCTTTCCCTTGGTTTCGGGTTTCTGGT
CGAAAGACGAAATCATCGGCCATGCCTTCGATCATGACCATCGCACAGTTGGCATGCTGTTGATTTTGGGCGCAGTCTTG
ACTTCGTTCTACATGGGTCGCCAAATCTCAATGGTTTTCTTTGGCGAACAACGTGATCAACACATTCACGCCCACGAAAG
CAGCCGCTGGATGACGATTCCATTGGCGATTTTGGCAGTCTTGACCCTTGCCAGCGGTTTGATCAATATTGTGGTTCTCC
ACCCATTGACCACATGGCTTGAGCCAATCGTCGAAGAAGAAGCTGCCAAGTTCCACCTCAATATTGCCGCGATTGTGACG
ATCTTAGGTTTGGCATCGTTTGCTGCCGGCTTCTATCTCTACAATTGGGCAGCCAAGCACAAGCGCATCAAGCCCAACCA
ACGCGACCTCTTGCACCACTGGGGCGGCGATTTCTATGCCATCCTTGAGGAAAAATGGGGCTTCGATGCGTTGTATAACG
CGGTGTTGGTCAAGCCCTACAAGGCCTTGGCTAGCTTCTTTGGTAAGTTCTTCGATGTCAAAATTATTGATGGCATCGTT
AATGGCACGGCAGAGCTTGTCGGCTTGTCGGGTCGCGGCTTGCGAACGTTCCAATCGGGCTATGTACGCTCGTATGCACT
GATGTTTGTGATCGGTGTGGTGATCGTGCTTGGCTTCTTTGCGTTGCGCTAG

Upstream 100 bases:

>100_bases
GATTTTCCGTGCCAAAAAGACCACCAACATTGATGACGTGAATACGCTCAAGGGCTAGGCAACGGCCTTGCACCTTGCCG
AAGTGTCTACTGGAGAACTT

Downstream 100 bases:

>100_bases
GACGTGGAGCGCAGGCCTCGGCTTGCAACTTCACAAGGAGTAACCCTTGACGAATACAAACGACTTAGGTTTTACGATCT
TATCGCTGGTGGTGTTTTTA

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MAELIWLVPLLPLLGVVINTLLGLNDLRLSRANAHHDHGHDHGHGHGDAHHGHGDNPTAKRSGLIASVMVGLGFVLTVAT
LIELLGMPAKTTLGENNRWFDVTYWNWMAFGDLEVPFGFLIDQLSVTMMLLVTGVGTLIHLYAVGYMSHDERPTRFFVYL
NLFIVAMLMLVMGNNFVMLFLGWEGVGLCSFLLIGFWFEQRDPPWASVKAFVTNRVGDFGLLMAMFAIWALARKPDGTFL
HSLVFREVLEQGTVFSLQQYSTFFMGTQYTAAGAIAFMLLLGVTGKSAQIPLFVWLPDAMAGPTPVSALIHAATMVTAGV
YLMIRTHPIFELSPAVQSSVTFIGVATALVAASIALGQYDIKKVLAFSTVSQLGFMVAAVGMGAYVAAMFHLLTHGIFKA
LLFLGSGSVIHGFGNEQDMRKMGGLRKKMPVTFWTYIVGTMGLIGFPLVSGFWSKDEIIGHAFDHDHRTVGMLLILGAVL
TSFYMGRQISMVFFGEQRDQHIHAHESSRWMTIPLAILAVLTLASGLINIVVLHPLTTWLEPIVEEEAAKFHLNIAAIVT
ILGLASFAAGFYLYNWAAKHKRIKPNQRDLLHHWGGDFYAILEEKWGFDALYNAVLVKPYKALASFFGKFFDVKIIDGIV
NGTAELVGLSGRGLRTFQSGYVRSYALMFVIGVVIVLGFFALR

Sequences:

>Translated_683_residues
MAELIWLVPLLPLLGVVINTLLGLNDLRLSRANAHHDHGHDHGHGHGDAHHGHGDNPTAKRSGLIASVMVGLGFVLTVAT
LIELLGMPAKTTLGENNRWFDVTYWNWMAFGDLEVPFGFLIDQLSVTMMLLVTGVGTLIHLYAVGYMSHDERPTRFFVYL
NLFIVAMLMLVMGNNFVMLFLGWEGVGLCSFLLIGFWFEQRDPPWASVKAFVTNRVGDFGLLMAMFAIWALARKPDGTFL
HSLVFREVLEQGTVFSLQQYSTFFMGTQYTAAGAIAFMLLLGVTGKSAQIPLFVWLPDAMAGPTPVSALIHAATMVTAGV
YLMIRTHPIFELSPAVQSSVTFIGVATALVAASIALGQYDIKKVLAFSTVSQLGFMVAAVGMGAYVAAMFHLLTHGIFKA
LLFLGSGSVIHGFGNEQDMRKMGGLRKKMPVTFWTYIVGTMGLIGFPLVSGFWSKDEIIGHAFDHDHRTVGMLLILGAVL
TSFYMGRQISMVFFGEQRDQHIHAHESSRWMTIPLAILAVLTLASGLINIVVLHPLTTWLEPIVEEEAAKFHLNIAAIVT
ILGLASFAAGFYLYNWAAKHKRIKPNQRDLLHHWGGDFYAILEEKWGFDALYNAVLVKPYKALASFFGKFFDVKIIDGIV
NGTAELVGLSGRGLRTFQSGYVRSYALMFVIGVVIVLGFFALR
>Mature_682_residues
AELIWLVPLLPLLGVVINTLLGLNDLRLSRANAHHDHGHDHGHGHGDAHHGHGDNPTAKRSGLIASVMVGLGFVLTVATL
IELLGMPAKTTLGENNRWFDVTYWNWMAFGDLEVPFGFLIDQLSVTMMLLVTGVGTLIHLYAVGYMSHDERPTRFFVYLN
LFIVAMLMLVMGNNFVMLFLGWEGVGLCSFLLIGFWFEQRDPPWASVKAFVTNRVGDFGLLMAMFAIWALARKPDGTFLH
SLVFREVLEQGTVFSLQQYSTFFMGTQYTAAGAIAFMLLLGVTGKSAQIPLFVWLPDAMAGPTPVSALIHAATMVTAGVY
LMIRTHPIFELSPAVQSSVTFIGVATALVAASIALGQYDIKKVLAFSTVSQLGFMVAAVGMGAYVAAMFHLLTHGIFKAL
LFLGSGSVIHGFGNEQDMRKMGGLRKKMPVTFWTYIVGTMGLIGFPLVSGFWSKDEIIGHAFDHDHRTVGMLLILGAVLT
SFYMGRQISMVFFGEQRDQHIHAHESSRWMTIPLAILAVLTLASGLINIVVLHPLTTWLEPIVEEEAAKFHLNIAAIVTI
LGLASFAAGFYLYNWAAKHKRIKPNQRDLLHHWGGDFYAILEEKWGFDALYNAVLVKPYKALASFFGKFFDVKIIDGIVN
GTAELVGLSGRGLRTFQSGYVRSYALMFVIGVVIVLGFFALR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=477, Percent_Identity=36.2683438155136, Blast_Score=274, Evalue=2e-73,
Organism=Escherichia coli, GI1788614, Length=610, Percent_Identity=39.672131147541, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788829, Length=449, Percent_Identity=27.8396436525612, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1788831, Length=425, Percent_Identity=28.7058823529412, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788827, Length=478, Percent_Identity=25.9414225941423, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI2367154, Length=445, Percent_Identity=23.8202247191011, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788613, Length=398, Percent_Identity=24.3718592964824, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75229; Mature: 75097

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELIWLVPLLPLLGVVINTLLGLNDLRLSRANAHHDHGHDHGHGHGDAHHGHGDNPTAK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
RSGLIASVMVGLGFVLTVATLIELLGMPAKTTLGENNRWFDVTYWNWMAFGDLEVPFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHH
IDQLSVTMMLLVTGVGTLIHLYAVGYMSHDERPTRFFVYLNLFIVAMLMLVMGNNFVMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEE
LGWEGVGLCSFLLIGFWFEQRDPPWASVKAFVTNRVGDFGLLMAMFAIWALARKPDGTFL
ECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHH
HSLVFREVLEQGTVFSLQQYSTFFMGTQYTAAGAIAFMLLLGVTGKSAQIPLFVWLPDAM
HHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
AGPTPVSALIHAATMVTAGVYLMIRTHPIFELSPAVQSSVTFIGVATALVAASIALGQYD
CCCCHHHHHHHHHHHHHHCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCHHH
IKKVLAFSTVSQLGFMVAAVGMGAYVAAMFHLLTHGIFKALLFLGSGSVIHGFGNEQDMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHH
KMGGLRKKMPVTFWTYIVGTMGLIGFPLVSGFWSKDEIIGHAFDHDHRTVGMLLILGAVL
HHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
TSFYMGRQISMVFFGEQRDQHIHAHESSRWMTIPLAILAVLTLASGLINIVVLHPLTTWL
HHHHHCCEEEEEEECCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EPIVEEEAAKFHLNIAAIVTILGLASFAAGFYLYNWAAKHKRIKPNQRDLLHHWGGDFYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEE
ILEEKWGFDALYNAVLVKPYKALASFFGKFFDVKIIDGIVNGTAELVGLSGRGLRTFQSG
EEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCHHHHHH
YVRSYALMFVIGVVIVLGFFALR
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELIWLVPLLPLLGVVINTLLGLNDLRLSRANAHHDHGHDHGHGHGDAHHGHGDNPTAK
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
RSGLIASVMVGLGFVLTVATLIELLGMPAKTTLGENNRWFDVTYWNWMAFGDLEVPFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHH
IDQLSVTMMLLVTGVGTLIHLYAVGYMSHDERPTRFFVYLNLFIVAMLMLVMGNNFVMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEE
LGWEGVGLCSFLLIGFWFEQRDPPWASVKAFVTNRVGDFGLLMAMFAIWALARKPDGTFL
ECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHH
HSLVFREVLEQGTVFSLQQYSTFFMGTQYTAAGAIAFMLLLGVTGKSAQIPLFVWLPDAM
HHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
AGPTPVSALIHAATMVTAGVYLMIRTHPIFELSPAVQSSVTFIGVATALVAASIALGQYD
CCCCHHHHHHHHHHHHHHCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCHHH
IKKVLAFSTVSQLGFMVAAVGMGAYVAAMFHLLTHGIFKALLFLGSGSVIHGFGNEQDMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHH
KMGGLRKKMPVTFWTYIVGTMGLIGFPLVSGFWSKDEIIGHAFDHDHRTVGMLLILGAVL
HHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
TSFYMGRQISMVFFGEQRDQHIHAHESSRWMTIPLAILAVLTLASGLINIVVLHPLTTWL
HHHHHCCEEEEEEECCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EPIVEEEAAKFHLNIAAIVTILGLASFAAGFYLYNWAAKHKRIKPNQRDLLHHWGGDFYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEE
ILEEKWGFDALYNAVLVKPYKALASFFGKFFDVKIIDGIVNGTAELVGLSGRGLRTFQSG
EEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCHHHHHH
YVRSYALMFVIGVVIVLGFFALR
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]