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The map label for this gene is trpE [H]

Identifier: 159899481

GI number: 159899481

Start: 3736977

End: 3738494

Strand: Reverse

Name: trpE [H]

Synonym: Haur_2962

Alternate gene names: 159899481

Gene position: 3738494-3736977 (Counterclockwise)

Preceding gene: 159899482

Following gene: 159899480

Centisome position: 58.91

GC content: 51.84

Gene sequence:

>1518_bases
ATGGCTTCGCCAACATTTGAACAAGTGCAAGCATGGGCTGCGGCTGGCTACACCCAATGTGCAGTCTATCGTGAGTTAGT
CGCCGATTTGGAAACGCCAGTGTCGGCGTACTTGAAGGTTGCTCAGGGTCATTATAGTTTCTTGCTTGAAAGTGTTGAGG
GTGGCGAGCAAATTGGTCGCTATTCATTTATTGGCTGTGAGCCTCATTTAATTATTCGTGGCCTTGGCCAGCAAAGTATT
ATTGAAACTGCCAATGGCGAACGTACCAGCTTTGATGATCTGACGACGCTTGATCAATTAGAACGCTTGGTGGTTGGCAC
GCAACGGGCTAACCCTGCGCCTCAACCTGATTTGCCGCGCTTTACGGGCGGGGCGGTTGGCTTTTTGGGCTATGAAACTG
TGCGCACGTTTGAACGTTTGCCCGCGCCAACCCTGCGCCCATTGCAAATTCCCGATGGCGTGTGGATGGTGGTCAAAACG
GTTTTGGCTTTCGACCATGTGCGCCATACGATCAAAATTATGAGCACACTGGTGTTTGATTCGGCGGTAGATTTGGCAAC
TCAATTTGCCGAAGCCAACCAAGCGATCGAAGCCATGACCAAAAAATTGGTACGGCCATTAGCACCCGAAGTCTATAGCT
CAAGCGCCGCCTCGCCCAGCTTACCCGAACTCAACGAGCAATTGCAATCAAATCAATCGTTTAGCGAATTTAGCACCGCG
ATTGAAAAGGCTCGCGAATATATTCGGGCTGGCGATATTTTTCAAGTGGTGTTATCGCAGCGTTTTCAGCGTGAAACCGA
TGCCGAGCCATTTGCGGTCTATCGAGCACTGCGCACGGTCAATCCATCACCATACATGTTCTTTTTGAATGTGCCTGATG
CGGCGATTATTGGGGCATCGCCCGAAATGTTGGTGCGGGTTGAAGATGGCATTATTGAGACCCACCCAATTGCTGGTACG
CGCCGCCGTGGCCGCGATGCCGATGACGAAGCTCGCATGCAGGCTGAATTATTAGCCGACGAAAAAGAACGGGCTGAGCA
TTTGATGCTGGTTGATCTTGGGCGCAACGATGTGGGGCGGGTTTCGCTGCCTGGCACCGTCCACGTGCCCAAATTTATGC
AAATTGAAAAATATTCGCATGTGATGCACTTAGTTTCGGTGGTCAAAGGCACGCTGGATACCTCGCGCTACTCGCCATTG
CATGCCTTACGCGCCTGCTTCCCTGCTGGCACGCTGACTGGTGCGCCCAAAGTGCGGGCCATGGAAATTATCGCTGAATT
AGAGCCAAGCCAACGCGGGCCATATGGTGGTTGCGTTGGCTATGTCTCGTTTGGCGGGTTGTCGCTTGACACAGCGATTA
CTATTCGCACAATGGTTATCAAAGATGGCGTAGCCTATATGCAAGCTGGCGCGGGGATTGTCGCCGATAGCGATGTTAAA
TTGGAAGATCTCGAAACCCGCAACAAAGCTGGTTCGCTGATTCGCGCCTTGCACGTCGCCGAGATGTTGGAGTTGTAA

Upstream 100 bases:

>100_bases
TTTAGGCTGATTTTACAATTGATCTTTTTTTTACATTCCTCGAACTAATCCCTGGCATCTGACCCCTGACCCCTCTTCTT
ATAGTTTTTATGGAGCGTTC

Downstream 100 bases:

>100_bases
TGTTGGGGGTCGGAGATCGGTTGTTGGAGGTCGGGTTAAGGTCGAAGTCATTTTAGCCAATTTGGGAATATTGATTTAAG
CTATAAATGACTATAACCTT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MASPTFEQVQAWAAAGYTQCAVYRELVADLETPVSAYLKVAQGHYSFLLESVEGGEQIGRYSFIGCEPHLIIRGLGQQSI
IETANGERTSFDDLTTLDQLERLVVGTQRANPAPQPDLPRFTGGAVGFLGYETVRTFERLPAPTLRPLQIPDGVWMVVKT
VLAFDHVRHTIKIMSTLVFDSAVDLATQFAEANQAIEAMTKKLVRPLAPEVYSSSAASPSLPELNEQLQSNQSFSEFSTA
IEKAREYIRAGDIFQVVLSQRFQRETDAEPFAVYRALRTVNPSPYMFFLNVPDAAIIGASPEMLVRVEDGIIETHPIAGT
RRRGRDADDEARMQAELLADEKERAEHLMLVDLGRNDVGRVSLPGTVHVPKFMQIEKYSHVMHLVSVVKGTLDTSRYSPL
HALRACFPAGTLTGAPKVRAMEIIAELEPSQRGPYGGCVGYVSFGGLSLDTAITIRTMVIKDGVAYMQAGAGIVADSDVK
LEDLETRNKAGSLIRALHVAEMLEL

Sequences:

>Translated_505_residues
MASPTFEQVQAWAAAGYTQCAVYRELVADLETPVSAYLKVAQGHYSFLLESVEGGEQIGRYSFIGCEPHLIIRGLGQQSI
IETANGERTSFDDLTTLDQLERLVVGTQRANPAPQPDLPRFTGGAVGFLGYETVRTFERLPAPTLRPLQIPDGVWMVVKT
VLAFDHVRHTIKIMSTLVFDSAVDLATQFAEANQAIEAMTKKLVRPLAPEVYSSSAASPSLPELNEQLQSNQSFSEFSTA
IEKAREYIRAGDIFQVVLSQRFQRETDAEPFAVYRALRTVNPSPYMFFLNVPDAAIIGASPEMLVRVEDGIIETHPIAGT
RRRGRDADDEARMQAELLADEKERAEHLMLVDLGRNDVGRVSLPGTVHVPKFMQIEKYSHVMHLVSVVKGTLDTSRYSPL
HALRACFPAGTLTGAPKVRAMEIIAELEPSQRGPYGGCVGYVSFGGLSLDTAITIRTMVIKDGVAYMQAGAGIVADSDVK
LEDLETRNKAGSLIRALHVAEMLEL
>Mature_504_residues
ASPTFEQVQAWAAAGYTQCAVYRELVADLETPVSAYLKVAQGHYSFLLESVEGGEQIGRYSFIGCEPHLIIRGLGQQSII
ETANGERTSFDDLTTLDQLERLVVGTQRANPAPQPDLPRFTGGAVGFLGYETVRTFERLPAPTLRPLQIPDGVWMVVKTV
LAFDHVRHTIKIMSTLVFDSAVDLATQFAEANQAIEAMTKKLVRPLAPEVYSSSAASPSLPELNEQLQSNQSFSEFSTAI
EKAREYIRAGDIFQVVLSQRFQRETDAEPFAVYRALRTVNPSPYMFFLNVPDAAIIGASPEMLVRVEDGIIETHPIAGTR
RRGRDADDEARMQAELLADEKERAEHLMLVDLGRNDVGRVSLPGTVHVPKFMQIEKYSHVMHLVSVVKGTLDTSRYSPLH
ALRACFPAGTLTGAPKVRAMEIIAELEPSQRGPYGGCVGYVSFGGLSLDTAITIRTMVIKDGVAYMQAGAGIVADSDVKL
EDLETRNKAGSLIRALHVAEMLEL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=385, Percent_Identity=41.038961038961, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1788114, Length=457, Percent_Identity=33.9168490153173, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1786809, Length=264, Percent_Identity=29.9242424242424, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082077, Length=264, Percent_Identity=28.4090909090909, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=470, Percent_Identity=41.7021276595745, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324361, Length=419, Percent_Identity=25.0596658711217, Blast_Score=119, Evalue=9e-28,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55413; Mature: 55282

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPTFEQVQAWAAAGYTQCAVYRELVADLETPVSAYLKVAQGHYSFLLESVEGGEQIGR
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCHHHHCC
YSFIGCEPHLIIRGLGQQSIIETANGERTSFDDLTTLDQLERLVVGTQRANPAPQPDLPR
EEEECCCHHHHEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FTGGAVGFLGYETVRTFERLPAPTLRPLQIPDGVWMVVKTVLAFDHVRHTIKIMSTLVFD
CCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVDLATQFAEANQAIEAMTKKLVRPLAPEVYSSSAASPSLPELNEQLQSNQSFSEFSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHH
IEKAREYIRAGDIFQVVLSQRFQRETDAEPFAVYRALRTVNPSPYMFFLNVPDAAIIGAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECCC
PEMLVRVEDGIIETHPIAGTRRRGRDADDEARMQAELLADEKERAEHLMLVDLGRNDVGR
CCEEEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCCEEEEEECCCCCCCE
VSLPGTVHVPKFMQIEKYSHVMHLVSVVKGTLDTSRYSPLHALRACFPAGTLTGAPKVRA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHH
MEIIAELEPSQRGPYGGCVGYVSFGGLSLDTAITIRTMVIKDGVAYMQAGAGIVADSDVK
HHHHHHCCCCCCCCCCCEEHHHHCCCEEECHHHHEEHHHHHCCHHHHHCCCCEEECCCCC
LEDLETRNKAGSLIRALHVAEMLEL
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASPTFEQVQAWAAAGYTQCAVYRELVADLETPVSAYLKVAQGHYSFLLESVEGGEQIGR
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCHHHHCC
YSFIGCEPHLIIRGLGQQSIIETANGERTSFDDLTTLDQLERLVVGTQRANPAPQPDLPR
EEEECCCHHHHEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FTGGAVGFLGYETVRTFERLPAPTLRPLQIPDGVWMVVKTVLAFDHVRHTIKIMSTLVFD
CCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVDLATQFAEANQAIEAMTKKLVRPLAPEVYSSSAASPSLPELNEQLQSNQSFSEFSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHH
IEKAREYIRAGDIFQVVLSQRFQRETDAEPFAVYRALRTVNPSPYMFFLNVPDAAIIGAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECCC
PEMLVRVEDGIIETHPIAGTRRRGRDADDEARMQAELLADEKERAEHLMLVDLGRNDVGR
CCEEEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCCEEEEEECCCCCCCE
VSLPGTVHVPKFMQIEKYSHVMHLVSVVKGTLDTSRYSPLHALRACFPAGTLTGAPKVRA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHH
MEIIAELEPSQRGPYGGCVGYVSFGGLSLDTAITIRTMVIKDGVAYMQAGAGIVADSDVK
HHHHHHCCCCCCCCCCCEEHHHHCCCEEECHHHHEEHHHHHCCHHHHHCCCCEEECCCCC
LEDLETRNKAGSLIRALHVAEMLEL
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]