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The map label for this gene is nrdA [H]

Identifier: 159899094

GI number: 159899094

Start: 3300850

End: 3303270

Strand: Reverse

Name: nrdA [H]

Synonym: Haur_2575

Alternate gene names: 159899094

Gene position: 3303270-3300850 (Counterclockwise)

Preceding gene: 159899099

Following gene: 159899093

Centisome position: 52.05

GC content: 51.55

Gene sequence:

>2421_bases
ATGAATGAGATCGAGGTCGGGGCTAGCGCCTCTCCTGAACAGGCTCCATGGCTTTATCAATTAATCGTTGAAGCTTGTGC
TGCTTATCCCCAAACAACTGACGCGAATACGCTCTGGCAGGCGGCGAGTTTGGGCTTTTATCCCAATATGGCGGTTGCCG
AGCAATTGCAGGCCTGTTGCTTAACCGCTCGAAGCTGGATTGAGCAGGAGCCGGATTATAGTTTTGTGGCCGCCGCGCTC
TTGGCCAGCCAACTGCACTTTGAGGTGCTTGGCGAATATTTGGCGACTCCAGCGGTTGTGCCACGCTATGCGAGTGCTTT
TGTTGATTATATTCAGGCTGGAATTGCCCAAGGCTTGCTCGACCCCAAACTGGCTAGCTTCGATTTGGCTCGTTTAGCAG
CGGCAATTGTGCCCGAGCGCGATGCTCTTTTGGCTTATCCTGGCCTGCAAACCCTGTATGACCGCTATTTTATTCAGTGG
CAGGGCTTGCGCCGTGAGTTGCCGCAAATCTTTTGGATGCGTGTTGCAATGGGTTTGGCCTTGAATGAGGCTGATCGTGA
AGCCCAAACCTTGCGTTTTTACGAGGTGCTGTCGCAATTCCACTTTACTTCGGCTACCCCAACCTTGTTCAATGCTGCCA
CTACCCATCCCCAATTATCGTCGTGCTATCTCTCGACGGTCGGCGATGATCTTGAGGCAATCTTCGGGGCGATCAGCGAT
AACGCTATGCTTTCAAAATGGGCGGGCGGTTTGGGTAACGATTGGACTCCGGTTCGCGCCCTTGGCGCACCAATTCATGG
CACAAATGGTGTGAGCCAAGGGGTAATTCCCTTTCTCAAAATTGTCAATGATACGGCGATTGCGGTTAATCAAGGCGGCA
AACGTAAAGGTGCGGTTTGCGCCTATCTCGAAGCATGGCACGCTGATCTTGAAGATTTTCTCGATTTGCGCAAGCCAACT
GGCGATGAACGCCGCCGTACCCACGATATGCACACGGCCTTGTGGGTTCCCGATTTGTTGATGGAACGGGTGTTGAGCAA
TGGCTCATGGAGCTTGTTTTCGCCCGATGAAGTCCCCGATTTGCACGATTTGTATGGTCAAGACTTTGCGGTGCGCTACG
CCGAATATGAGGCGCTAGCGGCTCAAGGCTTGATGCGTTCAGCACGTCAGGTTGAGGCGGTAGCACTCTGGCGCAAAGTC
TTGACGCGCCTGTTTGAAACCGGCCATCCTTGGATTACTTGGAAGGATGCTGCCAATGTGCGCTCGCCCCAAGATCATGT
TGGGGTGATTCATAGCAGTAATTTATGCACCGAAATTCTGCTGAATACCTCGGCAGATGAGATTGCAGTTTGTAATCTTG
GCTCGATTAATTTGGCGGCGCATATTCGTGATGGTTCACTTGACCTTGAAAAATTGCGTACCACGGTTACGACCGCAGTG
CGCATGCTCGATAACGTGATCGATATTAATTTTTATCCGCGTCCCCAAGCGGCTCAAGCCAATGCCCGCCATCGCCCAAT
TGGCTTGGGTTTGATGGGTTTTCAGGATGCTTTGTATGCATTGAAGATTGGCTATGCCAGCCAAGCAGCGGTCGAATTTT
CCGATCGTTCGATGGAAGCCATTGCCTATTTTGCGGTTGCTGCCTCAATTGAGTTGGCGCGGGAACGCGGGGCATACCCT
AGTTTTCGTGGCTCAAAATGGGATCGCGGCATGTTGCCGATCGATAGTTTGGCAATTTTAGCCGAGCAGCGCGACAGCAA
GCCCGAACTTGATCACAGCAGCCATTACGATTGGCAGCCGCTGCGCGAGGCTTTGGCTCAATATGGCATTCGTAATAGCA
ATTTGTTGGCAATTGCTCCGACCGCTACGATTGCCAATATCGTTGGCACAAGTCAATCAATTGAGCCAACCTATCGCCAT
TTGTACGTCAAAAGCAATCTTTCGGGTGATTTCACCACGGTCAATCGGGCTTTGGTCGATGCGCTCAAAGCTCGCGGTTT
GTGGGATGTTGATCTGCTGGCCGAATTGAAATATTACGATGGCGCAATCAGCCAAATCGAACGAATTCCTGCTGAACTCA
AAACTCAATTTTTGACTGCCTTCGAGATTGCCCCCGAATGGCTGATTGCCTGCGCTGCTCGTCGCCAAAAATGGATCGAT
ATGGGTCAATCGCTCAATTTGTATGTGGCTGAAACCAGCGGCAAACGCTTGAATGAGATTTATCTGACGGCGTGGCGTAT
GGGATTAAAAACCACCTATTACCTGCGCACGCTAGCCGCGACCCAAATTGAAAAATCGACCTTGGATATCAATCGTTTTG
GGGTGCAACCACGCTGGATGCGCAACCGCAGCGAATCGGCCAGCGTGCTGAGCGATAACGTTTGTCCAATCGATGACCCT
AGTTGCGAAGCCTGTGAGTAG

Upstream 100 bases:

>100_bases
AATTAATGCCCATGGGCTGCTGCCCATGGTTTGGTAATGGTTTATGCCTGTTCCGCTAGGGAGCAGGCATTTTTTTATTT
AGCTCAATTAAGGATGCTCT

Downstream 100 bases:

>100_bases
CGAGGAATGTTGCATGACTGAACAATTTGGCCGCTTTAATGCCAGCGATAAACGCCTGATCAATTGTAATCAAGTTGATG
TAAACCAATTAATGCCGTTG

Product: ribonucleoside-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MNEIEVGASASPEQAPWLYQLIVEACAAYPQTTDANTLWQAASLGFYPNMAVAEQLQACCLTARSWIEQEPDYSFVAAAL
LASQLHFEVLGEYLATPAVVPRYASAFVDYIQAGIAQGLLDPKLASFDLARLAAAIVPERDALLAYPGLQTLYDRYFIQW
QGLRRELPQIFWMRVAMGLALNEADREAQTLRFYEVLSQFHFTSATPTLFNAATTHPQLSSCYLSTVGDDLEAIFGAISD
NAMLSKWAGGLGNDWTPVRALGAPIHGTNGVSQGVIPFLKIVNDTAIAVNQGGKRKGAVCAYLEAWHADLEDFLDLRKPT
GDERRRTHDMHTALWVPDLLMERVLSNGSWSLFSPDEVPDLHDLYGQDFAVRYAEYEALAAQGLMRSARQVEAVALWRKV
LTRLFETGHPWITWKDAANVRSPQDHVGVIHSSNLCTEILLNTSADEIAVCNLGSINLAAHIRDGSLDLEKLRTTVTTAV
RMLDNVIDINFYPRPQAAQANARHRPIGLGLMGFQDALYALKIGYASQAAVEFSDRSMEAIAYFAVAASIELARERGAYP
SFRGSKWDRGMLPIDSLAILAEQRDSKPELDHSSHYDWQPLREALAQYGIRNSNLLAIAPTATIANIVGTSQSIEPTYRH
LYVKSNLSGDFTTVNRALVDALKARGLWDVDLLAELKYYDGAISQIERIPAELKTQFLTAFEIAPEWLIACAARRQKWID
MGQSLNLYVAETSGKRLNEIYLTAWRMGLKTTYYLRTLAATQIEKSTLDINRFGVQPRWMRNRSESASVLSDNVCPIDDP
SCEACE

Sequences:

>Translated_806_residues
MNEIEVGASASPEQAPWLYQLIVEACAAYPQTTDANTLWQAASLGFYPNMAVAEQLQACCLTARSWIEQEPDYSFVAAAL
LASQLHFEVLGEYLATPAVVPRYASAFVDYIQAGIAQGLLDPKLASFDLARLAAAIVPERDALLAYPGLQTLYDRYFIQW
QGLRRELPQIFWMRVAMGLALNEADREAQTLRFYEVLSQFHFTSATPTLFNAATTHPQLSSCYLSTVGDDLEAIFGAISD
NAMLSKWAGGLGNDWTPVRALGAPIHGTNGVSQGVIPFLKIVNDTAIAVNQGGKRKGAVCAYLEAWHADLEDFLDLRKPT
GDERRRTHDMHTALWVPDLLMERVLSNGSWSLFSPDEVPDLHDLYGQDFAVRYAEYEALAAQGLMRSARQVEAVALWRKV
LTRLFETGHPWITWKDAANVRSPQDHVGVIHSSNLCTEILLNTSADEIAVCNLGSINLAAHIRDGSLDLEKLRTTVTTAV
RMLDNVIDINFYPRPQAAQANARHRPIGLGLMGFQDALYALKIGYASQAAVEFSDRSMEAIAYFAVAASIELARERGAYP
SFRGSKWDRGMLPIDSLAILAEQRDSKPELDHSSHYDWQPLREALAQYGIRNSNLLAIAPTATIANIVGTSQSIEPTYRH
LYVKSNLSGDFTTVNRALVDALKARGLWDVDLLAELKYYDGAISQIERIPAELKTQFLTAFEIAPEWLIACAARRQKWID
MGQSLNLYVAETSGKRLNEIYLTAWRMGLKTTYYLRTLAATQIEKSTLDINRFGVQPRWMRNRSESASVLSDNVCPIDDP
SCEACE
>Mature_806_residues
MNEIEVGASASPEQAPWLYQLIVEACAAYPQTTDANTLWQAASLGFYPNMAVAEQLQACCLTARSWIEQEPDYSFVAAAL
LASQLHFEVLGEYLATPAVVPRYASAFVDYIQAGIAQGLLDPKLASFDLARLAAAIVPERDALLAYPGLQTLYDRYFIQW
QGLRRELPQIFWMRVAMGLALNEADREAQTLRFYEVLSQFHFTSATPTLFNAATTHPQLSSCYLSTVGDDLEAIFGAISD
NAMLSKWAGGLGNDWTPVRALGAPIHGTNGVSQGVIPFLKIVNDTAIAVNQGGKRKGAVCAYLEAWHADLEDFLDLRKPT
GDERRRTHDMHTALWVPDLLMERVLSNGSWSLFSPDEVPDLHDLYGQDFAVRYAEYEALAAQGLMRSARQVEAVALWRKV
LTRLFETGHPWITWKDAANVRSPQDHVGVIHSSNLCTEILLNTSADEIAVCNLGSINLAAHIRDGSLDLEKLRTTVTTAV
RMLDNVIDINFYPRPQAAQANARHRPIGLGLMGFQDALYALKIGYASQAAVEFSDRSMEAIAYFAVAASIELARERGAYP
SFRGSKWDRGMLPIDSLAILAEQRDSKPELDHSSHYDWQPLREALAQYGIRNSNLLAIAPTATIANIVGTSQSIEPTYRH
LYVKSNLSGDFTTVNRALVDALKARGLWDVDLLAELKYYDGAISQIERIPAELKTQFLTAFEIAPEWLIACAARRQKWID
MGQSLNLYVAETSGKRLNEIYLTAWRMGLKTTYYLRTLAATQIEKSTLDINRFGVQPRWMRNRSESASVLSDNVCPIDDP
SCEACE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=709, Percent_Identity=39.4922425952045, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI2367133, Length=743, Percent_Identity=29.07133243607, Blast_Score=258, Evalue=1e-69,
Organism=Escherichia coli, GI1789030, Length=624, Percent_Identity=30.7692307692308, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17555242, Length=739, Percent_Identity=38.0243572395129, Blast_Score=486, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320914, Length=749, Percent_Identity=37.1161548731642, Blast_Score=472, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322123, Length=749, Percent_Identity=36.3150867823765, Blast_Score=463, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17352481, Length=758, Percent_Identity=37.598944591029, Blast_Score=500, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 89564; Mature: 89564

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIEVGASASPEQAPWLYQLIVEACAAYPQTTDANTLWQAASLGFYPNMAVAEQLQACC
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LTARSWIEQEPDYSFVAAALLASQLHFEVLGEYLATPAVVPRYASAFVDYIQAGIAQGLL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
DPKLASFDLARLAAAIVPERDALLAYPGLQTLYDRYFIQWQGLRRELPQIFWMRVAMGLA
CCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEADREAQTLRFYEVLSQFHFTSATPTLFNAATTHPQLSSCYLSTVGDDLEAIFGAISD
HCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHCC
NAMLSKWAGGLGNDWTPVRALGAPIHGTNGVSQGVIPFLKIVNDTAIAVNQGGKRKGAVC
CHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHH
AYLEAWHADLEDFLDLRKPTGDERRRTHDMHTALWVPDLLMERVLSNGSWSLFSPDEVPD
HHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LHDLYGQDFAVRYAEYEALAAQGLMRSARQVEAVALWRKVLTRLFETGHPWITWKDAANV
HHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
RSPQDHVGVIHSSNLCTEILLNTSADEIAVCNLGSINLAAHIRDGSLDLEKLRTTVTTAV
CCCHHHEEEEECCCHHHHHHHCCCCCCEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHH
RMLDNVIDINFYPRPQAAQANARHRPIGLGLMGFQDALYALKIGYASQAAVEFSDRSMEA
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHEEECCCHHHH
IAYFAVAASIELARERGAYPSFRGSKWDRGMLPIDSLAILAEQRDSKPELDHSSHYDWQP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
LREALAQYGIRNSNLLAIAPTATIANIVGTSQSIEPTYRHLYVKSNLSGDFTTVNRALVD
HHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHH
ALKARGLWDVDLLAELKYYDGAISQIERIPAELKTQFLTAFEIAPEWLIACAARRQKWID
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGQSLNLYVAETSGKRLNEIYLTAWRMGLKTTYYLRTLAATQIEKSTLDINRFGVQPRWM
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHH
RNRSESASVLSDNVCPIDDPSCEACE
HCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNEIEVGASASPEQAPWLYQLIVEACAAYPQTTDANTLWQAASLGFYPNMAVAEQLQACC
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LTARSWIEQEPDYSFVAAALLASQLHFEVLGEYLATPAVVPRYASAFVDYIQAGIAQGLL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
DPKLASFDLARLAAAIVPERDALLAYPGLQTLYDRYFIQWQGLRRELPQIFWMRVAMGLA
CCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEADREAQTLRFYEVLSQFHFTSATPTLFNAATTHPQLSSCYLSTVGDDLEAIFGAISD
HCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHCC
NAMLSKWAGGLGNDWTPVRALGAPIHGTNGVSQGVIPFLKIVNDTAIAVNQGGKRKGAVC
CHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHH
AYLEAWHADLEDFLDLRKPTGDERRRTHDMHTALWVPDLLMERVLSNGSWSLFSPDEVPD
HHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LHDLYGQDFAVRYAEYEALAAQGLMRSARQVEAVALWRKVLTRLFETGHPWITWKDAANV
HHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
RSPQDHVGVIHSSNLCTEILLNTSADEIAVCNLGSINLAAHIRDGSLDLEKLRTTVTTAV
CCCHHHEEEEECCCHHHHHHHCCCCCCEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHH
RMLDNVIDINFYPRPQAAQANARHRPIGLGLMGFQDALYALKIGYASQAAVEFSDRSMEA
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHEEECCCHHHH
IAYFAVAASIELARERGAYPSFRGSKWDRGMLPIDSLAILAEQRDSKPELDHSSHYDWQP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
LREALAQYGIRNSNLLAIAPTATIANIVGTSQSIEPTYRHLYVKSNLSGDFTTVNRALVD
HHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHH
ALKARGLWDVDLLAELKYYDGAISQIERIPAELKTQFLTAFEIAPEWLIACAARRQKWID
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGQSLNLYVAETSGKRLNEIYLTAWRMGLKTTYYLRTLAATQIEKSTLDINRFGVQPRWM
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHH
RNRSESASVLSDNVCPIDDPSCEACE
HCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]