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The map label for this gene is tdh [H]

Identifier: 159899084

GI number: 159899084

Start: 3288938

End: 3290002

Strand: Reverse

Name: tdh [H]

Synonym: Haur_2565

Alternate gene names: 159899084

Gene position: 3290002-3288938 (Counterclockwise)

Preceding gene: 159899085

Following gene: 159899079

Centisome position: 51.84

GC content: 53.43

Gene sequence:

>1065_bases
ATGGCAAATAATACGATGCGGGCGGTGCAAAAACCATCGGCAGCTCCAGGAGCCAAGCTGATCACTGCGCCGATTCCTCA
GCCAAAGCGTGATGAAGTGCTGATTCGAGTGCGAGCTTCGACGATTTGTGGCACCGACTTGCATATTTATAAATGGGACC
CGTGGGCACAAAGCCGCTTCAAAGCGCCGATGATTTTCGGCCATGAATTGGCTGGCGATGTGGTCGAGGTTGGCAGCGAT
GTGACGATGGTCAAGGTTGGCGATTTTGTCTCCGCCGAAACCCATATTGTCTGTGGTTATTGCTACCAGTGTCGCACTGG
CGCAGCCCATATTTGCCGCAACGTCGAAATTATTGGGGTTGATCGGCCTGGCTGTTTCGCTGAATATATTGCGGTTCCGG
CGGTCAATGTTTGGCGCAACGACCCAAATATGCCACCAGCCTTGGCTGCGGCTCAAGAGCCATTTGGCAATGCGGTGCAT
ACCGCCTTGGCAACCAACCTTTCAACTCGCAATGTCTTGGTGACTGGTTGTGGCCCGATTGGCTTGTTTGCGGTGGGGAT
CGCGCACGCAGCAGGAGCCAAGCAAATTTTCGCCACCGATATCAACCCCAAGCGCTTAGAAATGGCGCGAACCATGGGTG
CAACCCATGCTTTGGATTCACGCGACGATGTGGTGCATCATGTGCTGGCGGCGACCGAAGGCGAAGGCGTTGATGTGCTG
CTCGAAATGTCGGGCCATCCTAGTGCAATTGATCAGGGCTTTCGATCGTTGCGTTATGGTGGTTTTGCCTCATTGCTGGG
TTTACCACCCAACGGCTTGCCCGATTTCGACCTTGCCAACCATGTGGTGTTCAAAGGTGCGACCGTGTATGGCGTTTCAG
GCCGCAAAATGTTTGAAACCTGGTATCAAACCCAAGCCTTGGTGGCGGGCAATAAGGTCGATTTGCGTCCGATTATCACT
CATCACTTGCCTTTGGAAGAATTTGAAACCGCGTTTGAATTGATGCTGCGTGGCGAGGCTGCCAAAGTGGCTTTGTATCC
GCATGGGCTTGATGGTGCTTGGTAA

Upstream 100 bases:

>100_bases
TCCTGCCCGAAACCTTCGTGCCAATGAATCAAATGCTATTTGGGTGAAACAATGCAAACAATAAACGATCGTCCATGGGT
TTCAACGAGGAGACCAAACT

Downstream 100 bases:

>100_bases
TTAAACCCAAAGGCCGTTCAGTACGCCAACTGAGCGGCCTGCTCACTTAATCATTAATACGGCGTAAAGTATAACGACTG
CTATGGTTGATTTCCACTAG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MANNTMRAVQKPSAAPGAKLITAPIPQPKRDEVLIRVRASTICGTDLHIYKWDPWAQSRFKAPMIFGHELAGDVVEVGSD
VTMVKVGDFVSAETHIVCGYCYQCRTGAAHICRNVEIIGVDRPGCFAEYIAVPAVNVWRNDPNMPPALAAAQEPFGNAVH
TALATNLSTRNVLVTGCGPIGLFAVGIAHAAGAKQIFATDINPKRLEMARTMGATHALDSRDDVVHHVLAATEGEGVDVL
LEMSGHPSAIDQGFRSLRYGGFASLLGLPPNGLPDFDLANHVVFKGATVYGVSGRKMFETWYQTQALVAGNKVDLRPIIT
HHLPLEEFETAFELMLRGEAAKVALYPHGLDGAW

Sequences:

>Translated_354_residues
MANNTMRAVQKPSAAPGAKLITAPIPQPKRDEVLIRVRASTICGTDLHIYKWDPWAQSRFKAPMIFGHELAGDVVEVGSD
VTMVKVGDFVSAETHIVCGYCYQCRTGAAHICRNVEIIGVDRPGCFAEYIAVPAVNVWRNDPNMPPALAAAQEPFGNAVH
TALATNLSTRNVLVTGCGPIGLFAVGIAHAAGAKQIFATDINPKRLEMARTMGATHALDSRDDVVHHVLAATEGEGVDVL
LEMSGHPSAIDQGFRSLRYGGFASLLGLPPNGLPDFDLANHVVFKGATVYGVSGRKMFETWYQTQALVAGNKVDLRPIIT
HHLPLEEFETAFELMLRGEAAKVALYPHGLDGAW
>Mature_353_residues
ANNTMRAVQKPSAAPGAKLITAPIPQPKRDEVLIRVRASTICGTDLHIYKWDPWAQSRFKAPMIFGHELAGDVVEVGSDV
TMVKVGDFVSAETHIVCGYCYQCRTGAAHICRNVEIIGVDRPGCFAEYIAVPAVNVWRNDPNMPPALAAAQEPFGNAVHT
ALATNLSTRNVLVTGCGPIGLFAVGIAHAAGAKQIFATDINPKRLEMARTMGATHALDSRDDVVHHVLAATEGEGVDVLL
EMSGHPSAIDQGFRSLRYGGFASLLGLPPNGLPDFDLANHVVFKGATVYGVSGRKMFETWYQTQALVAGNKVDLRPIITH
HLPLEEFETAFELMLRGEAAKVALYPHGLDGAW

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=28.3132530120482, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI71743840, Length=349, Percent_Identity=28.9398280802292, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI262073058, Length=349, Percent_Identity=28.9398280802292, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=28.125, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=28.3236994219653, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=29.2613636363636, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=29.9435028248588, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71565152, Length=356, Percent_Identity=26.4044943820225, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=381, Percent_Identity=26.7716535433071, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1790045, Length=342, Percent_Identity=44.1520467836257, Blast_Score=311, Evalue=3e-86,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=30, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=28.9389067524116, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788407, Length=342, Percent_Identity=29.8245614035088, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787863, Length=236, Percent_Identity=31.3559322033898, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=28.0555555555556, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=28.1984334203655, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790718, Length=322, Percent_Identity=26.7080745341615, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=28.3707865168539, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=29.5212765957447, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=29.0625, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787572, Length=225, Percent_Identity=28, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=29.3413173652695, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17562878, Length=341, Percent_Identity=25.8064516129032, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=275, Percent_Identity=28.7272727272727, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562584, Length=276, Percent_Identity=29.7101449275362, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=202, Percent_Identity=36.1386138613861, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=381, Percent_Identity=24.9343832020997, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=383, Percent_Identity=24.8041775456919, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=376, Percent_Identity=23.4042553191489, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=346, Percent_Identity=29.1907514450867, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=346, Percent_Identity=29.1907514450867, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=29.3956043956044, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=310, Percent_Identity=27.741935483871, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319621, Length=265, Percent_Identity=32.4528301886792, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=266, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=266, Percent_Identity=31.203007518797, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=276, Percent_Identity=28.2608695652174, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=266, Percent_Identity=29.3233082706767, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=269, Percent_Identity=28.6245353159851, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17737897, Length=341, Percent_Identity=29.9120234604106, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17137530, Length=345, Percent_Identity=29.8550724637681, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=27.7310924369748, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221457811, Length=172, Percent_Identity=29.0697674418605, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551930, Length=172, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550770, Length=172, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38127; Mature: 37996

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNTMRAVQKPSAAPGAKLITAPIPQPKRDEVLIRVRASTICGTDLHIYKWDPWAQSRF
CCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEEEEECEEECCCEEEEEECCHHHHHC
KAPMIFGHELAGDVVEVGSDVTMVKVGDFVSAETHIVCGYCYQCRTGAAHICRNVEIIGV
CCCEEECHHHHCHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHHHHCCCEEEEE
DRPGCFAEYIAVPAVNVWRNDPNMPPALAAAQEPFGNAVHTALATNLSTRNVLVTGCGPI
CCCCHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHH
GLFAVGIAHAAGAKQIFATDINPKRLEMARTMGATHALDSRDDVVHHVLAATEGEGVDVL
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCEEEE
LEMSGHPSAIDQGFRSLRYGGFASLLGLPPNGLPDFDLANHVVFKGATVYGVSGRKMFET
EEECCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCEEEEECEEEEECCCHHHHHH
WYQTQALVAGNKVDLRPIITHHLPLEEFETAFELMLRGEAAKVALYPHGLDGAW
HHHHHHEECCCCEECCCHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
ANNTMRAVQKPSAAPGAKLITAPIPQPKRDEVLIRVRASTICGTDLHIYKWDPWAQSRF
CCCHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEEEEECEEECCCEEEEEECCHHHHHC
KAPMIFGHELAGDVVEVGSDVTMVKVGDFVSAETHIVCGYCYQCRTGAAHICRNVEIIGV
CCCEEECHHHHCHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHHHHCCCEEEEE
DRPGCFAEYIAVPAVNVWRNDPNMPPALAAAQEPFGNAVHTALATNLSTRNVLVTGCGPI
CCCCHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHH
GLFAVGIAHAAGAKQIFATDINPKRLEMARTMGATHALDSRDDVVHHVLAATEGEGVDVL
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCEEEE
LEMSGHPSAIDQGFRSLRYGGFASLLGLPPNGLPDFDLANHVVFKGATVYGVSGRKMFET
EEECCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCEEEEECEEEEECCCHHHHHH
WYQTQALVAGNKVDLRPIITHHLPLEEFETAFELMLRGEAAKVALYPHGLDGAW
HHHHHHEECCCCEECCCHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA