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The map label for this gene is yrhP [H]

Identifier: 159899081

GI number: 159899081

Start: 3286709

End: 3287344

Strand: Direct

Name: yrhP [H]

Synonym: Haur_2562

Alternate gene names: 159899081

Gene position: 3286709-3287344 (Clockwise)

Preceding gene: 159899080

Following gene: 159899082

Centisome position: 51.79

GC content: 51.42

Gene sequence:

>636_bases
ATGTTTGATGCTCAGTTAATTGGTTACACGCTCGCCGTCGCCTTATTAACCATCACGCCTGGCGCTGATACGCTGTTGGT
TATGCGCAACGTTTTGGCGCGTGGCCGCAAAGCTGGAATACTAGCGACGCTCGGCGTTAGTTCAGGCTTGTTCATCCATG
CACTGCTCTCAGGCCTTGGCTTATCGCTGATTTTAACTCGCTCGGCGCTGGCATTTAGCGTGGTCAAATGGGCAGGAGCG
CTCTACTTATGCTATCTTGGGGTGCAATCGCTACGCAGCGCCCTCAAACCCAATCTAGTAACCAACGAAATATCAAGCAC
TGCTGAGCCAAGCCTCAACCCGTGGCATGCCTACCGCGAAGGCTTGATCACCAACGTCTTGAACCCCAAAGTTGCCCTAT
TTTATCTGGCCTTCCTGCCCCAATTCATTCGCCCGAATGATCCAGTGATGCTGCGCTCATTGCTATTAACCTCGATTCAT
TTTGTGCTCGGCATCGTTTGGTTAGGCCTGATTACCCTAAGTTTGGATAAAATGCGCAGTTGGATGCTCAAACCACGGGT
GCGGGCTTGGATCGAAGGCAGTACGGGGCTTATTCTATTTGGATTTGGCATCCGCTTGGCGCTATCCAAACGTTAA

Upstream 100 bases:

>100_bases
TTCCGCGTGAAAGCTGTGTTTGAGGAATAATCGTTAGCTCAACCTACCCCTCTCTTGTCAGCAAACAGGAGAGGGGCTTT
ACTTTATATGGGAGCAGCCT

Downstream 100 bases:

>100_bases
CGCAACAATTCAGAGCTGGCTGCCGTATCATCCACAGCAAACCAAACGGGGGTTTACCCGTTCTAGGAGGTTCTGATGAA
AAATCAACGCGATACCATGA

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MFDAQLIGYTLAVALLTITPGADTLLVMRNVLARGRKAGILATLGVSSGLFIHALLSGLGLSLILTRSALAFSVVKWAGA
LYLCYLGVQSLRSALKPNLVTNEISSTAEPSLNPWHAYREGLITNVLNPKVALFYLAFLPQFIRPNDPVMLRSLLLTSIH
FVLGIVWLGLITLSLDKMRSWMLKPRVRAWIEGSTGLILFGFGIRLALSKR

Sequences:

>Translated_211_residues
MFDAQLIGYTLAVALLTITPGADTLLVMRNVLARGRKAGILATLGVSSGLFIHALLSGLGLSLILTRSALAFSVVKWAGA
LYLCYLGVQSLRSALKPNLVTNEISSTAEPSLNPWHAYREGLITNVLNPKVALFYLAFLPQFIRPNDPVMLRSLLLTSIH
FVLGIVWLGLITLSLDKMRSWMLKPRVRAWIEGSTGLILFGFGIRLALSKR
>Mature_211_residues
MFDAQLIGYTLAVALLTITPGADTLLVMRNVLARGRKAGILATLGVSSGLFIHALLSGLGLSLILTRSALAFSVVKWAGA
LYLCYLGVQSLRSALKPNLVTNEISSTAEPSLNPWHAYREGLITNVLNPKVALFYLAFLPQFIRPNDPVMLRSLLLTSIH
FVLGIVWLGLITLSLDKMRSWMLKPRVRAWIEGSTGLILFGFGIRLALSKR

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=179, Percent_Identity=32.9608938547486, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994978, Length=198, Percent_Identity=29.7979797979798, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788099, Length=201, Percent_Identity=28.8557213930348, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786522, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 23074; Mature: 23074

Theoretical pI: Translated: 11.15; Mature: 11.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDAQLIGYTLAVALLTITPGADTLLVMRNVLARGRKAGILATLGVSSGLFIHALLSGLG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
LSLILTRSALAFSVVKWAGALYLCYLGVQSLRSALKPNLVTNEISSTAEPSLNPWHAYRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHH
GLITNVLNPKVALFYLAFLPQFIRPNDPVMLRSLLLTSIHFVLGIVWLGLITLSLDKMRS
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WMLKPRVRAWIEGSTGLILFGFGIRLALSKR
HHHCHHHHHHCCCCCCEEEEECCCEEEECCC
>Mature Secondary Structure
MFDAQLIGYTLAVALLTITPGADTLLVMRNVLARGRKAGILATLGVSSGLFIHALLSGLG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
LSLILTRSALAFSVVKWAGALYLCYLGVQSLRSALKPNLVTNEISSTAEPSLNPWHAYRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHH
GLITNVLNPKVALFYLAFLPQFIRPNDPVMLRSLLLTSIHFVLGIVWLGLITLSLDKMRS
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WMLKPRVRAWIEGSTGLILFGFGIRLALSKR
HHHCHHHHHHCCCCCCEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]