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The map label for this gene is thiD [H]

Identifier: 159898959

GI number: 159898959

Start: 3123437

End: 3124231

Strand: Reverse

Name: thiD [H]

Synonym: Haur_2438

Alternate gene names: 159898959

Gene position: 3124231-3123437 (Counterclockwise)

Preceding gene: 159898960

Following gene: 159898954

Centisome position: 49.23

GC content: 51.7

Gene sequence:

>795_bases
ATGCGAGCAAAAGCATTAACTATCGCTGGCTCCGATTCGGGTGGCGGCGCGGGCATTCAGGCCGATCTCAAAACCTTTCA
TACCTATCAAGTTTATGGTAGCAGCGTAATTACGGCAATTACCGCTCAAAATACAATTGGAGTTCAAGCCTTTGAATTAG
TTAGCCCAAGCTTGATCGAACGCCAAATTGTGGCGGTTTTGGCTGATATTGGAGCTGATGCGATTAAAACGGGCATGCTT
GGCAACGCCGCGATCATCGAAACGGTGGCGAATAGCTTGCGTCAATATCCGGTGGCGTTGGTGGTTGATCCAGTGATGGT
TGCCAAGAGTGGCGATCGCTTATTAGCTGAGGAGGCGGTGCAGGCTTTATGTGAGCATTTAGTGCCAATCGCCAGCCTAA
TTACGCCCAATTTGCCTGAAGCCAGCGTTATGCTTGGCCGCGAAATTGCTGATGAACGCACGATGTATGCAGCGTTGGAT
GATTTGCTGAAGCTTGGCGCGAAGGCAGTTTTGCTCAAAGGTGGGCATCTCAAAGGCCAGCCGCTGGATTTATTTGCCGA
TGGCCAACAGGTGCTCGAACTGCGCTCAGAACGAATCGACACCCCCAACACTCACGGGACTGGCTGCACCTATGCGGCGG
CGATCACAGCATTGCTGGCGCGAGGCGAAGATTTAGTCAGTGCGGTTTGTCAAGCTCATGCATTTTTATACGCGGCGATT
GCGAGCGCCGAATCGATTGGAGCTGGCCATAGTCCGGTTAATCATTGGGCTTGGCTGAATGAGCGAACTGTTTAA

Upstream 100 bases:

>100_bases
GGTCAATCAACATAGCTACAATTTGGCCAGTGCCGCTCAGGCCTATCGCTATGCCATGCAATGTGAATACGATTTTTTTG
AAGCAGTGTGGAGTAACTAA

Downstream 100 bases:

>100_bases
CCCACTCCTTGCCCCTCATCTGTTTGGGTGTGAGGGGCAACCTTACTCCAACGAATGATTGGCTTGTTCGGCATTCCAGC
GTACCCAATCGCCATGGGCA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRAKALTIAGSDSGGGAGIQADLKTFHTYQVYGSSVITAITAQNTIGVQAFELVSPSLIERQIVAVLADIGADAIKTGML
GNAAIIETVANSLRQYPVALVVDPVMVAKSGDRLLAEEAVQALCEHLVPIASLITPNLPEASVMLGREIADERTMYAALD
DLLKLGAKAVLLKGGHLKGQPLDLFADGQQVLELRSERIDTPNTHGTGCTYAAAITALLARGEDLVSAVCQAHAFLYAAI
ASAESIGAGHSPVNHWAWLNERTV

Sequences:

>Translated_264_residues
MRAKALTIAGSDSGGGAGIQADLKTFHTYQVYGSSVITAITAQNTIGVQAFELVSPSLIERQIVAVLADIGADAIKTGML
GNAAIIETVANSLRQYPVALVVDPVMVAKSGDRLLAEEAVQALCEHLVPIASLITPNLPEASVMLGREIADERTMYAALD
DLLKLGAKAVLLKGGHLKGQPLDLFADGQQVLELRSERIDTPNTHGTGCTYAAAITALLARGEDLVSAVCQAHAFLYAAI
ASAESIGAGHSPVNHWAWLNERTV
>Mature_264_residues
MRAKALTIAGSDSGGGAGIQADLKTFHTYQVYGSSVITAITAQNTIGVQAFELVSPSLIERQIVAVLADIGADAIKTGML
GNAAIIETVANSLRQYPVALVVDPVMVAKSGDRLLAEEAVQALCEHLVPIASLITPNLPEASVMLGREIADERTMYAALD
DLLKLGAKAVLLKGGHLKGQPLDLFADGQQVLELRSERIDTPNTHGTGCTYAAAITALLARGEDLVSAVCQAHAFLYAAI
ASAESIGAGHSPVNHWAWLNERTV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=265, Percent_Identity=46.7924528301887, Blast_Score=202, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6325378, Length=275, Percent_Identity=31.6363636363636, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324997, Length=269, Percent_Identity=35.6877323420074, Blast_Score=121, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324517, Length=269, Percent_Identity=34.2007434944238, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27648; Mature: 27648

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKALTIAGSDSGGGAGIQADLKTFHTYQVYGSSVITAITAQNTIGVQAFELVSPSLIE
CCCEEEEEECCCCCCCCCCCHHHHHHHHHEECCCHHEEEEECCCCCCCHHHHHHCHHHHH
RQIVAVLADIGADAIKTGMLGNAAIIETVANSLRQYPVALVVDPVMVAKSGDRLLAEEAV
HHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEECHHHEECCCCHHHHHHHH
QALCEHLVPIASLITPNLPEASVMLGREIADERTMYAALDDLLKLGAKAVLLKGGHLKGQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PLDLFADGQQVLELRSERIDTPNTHGTGCTYAAAITALLARGEDLVSAVCQAHAFLYAAI
CCCHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ASAESIGAGHSPVNHWAWLNERTV
HHHHHCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MRAKALTIAGSDSGGGAGIQADLKTFHTYQVYGSSVITAITAQNTIGVQAFELVSPSLIE
CCCEEEEEECCCCCCCCCCCHHHHHHHHHEECCCHHEEEEECCCCCCCHHHHHHCHHHHH
RQIVAVLADIGADAIKTGMLGNAAIIETVANSLRQYPVALVVDPVMVAKSGDRLLAEEAV
HHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEECHHHEECCCCHHHHHHHH
QALCEHLVPIASLITPNLPEASVMLGREIADERTMYAALDDLLKLGAKAVLLKGGHLKGQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PLDLFADGQQVLELRSERIDTPNTHGTGCTYAAAITALLARGEDLVSAVCQAHAFLYAAI
CCCHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ASAESIGAGHSPVNHWAWLNERTV
HHHHHCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]