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The map label for this gene is tycC [H]

Identifier: 159898934

GI number: 159898934

Start: 3081398

End: 3086107

Strand: Direct

Name: tycC [H]

Synonym: Haur_2413

Alternate gene names: 159898934

Gene position: 3081398-3086107 (Clockwise)

Preceding gene: 159898933

Following gene: 159898935

Centisome position: 48.55

GC content: 50.76

Gene sequence:

>4710_bases
ATGACTGATTTTGCTGCAAAAATTGCTGCATTACCACCAGAAAAACAAGCGCTGTTGATTCGCCGACTGCAACAAGCAGC
CAACGAGCCACCAGCCTTGGTTGCCCAACCACGGACAACCAATACGCTGCCGTTATCGTTTGCCCAAGAGCGCCAATGGG
TGTTGTATCAGTGGGACCCAACCAGCCCGCTGTATAACATCGTTTATGGGGTGCGCTACCGTGGCAAGCTTGATATTGCC
GCCTTGCAAGCAGGCTTCAACACCATTGCCCAGCGCCATGAGGTGTTGCGCACGACCTTTTTGCTGGTTGATACAGTGCC
CCATCAGCAGATCCATGCTGAGCTTAAGCCAGGGTTTAGCGTGGTCGATTTACGCGATCTGGCCGAAACTGAGCGCGATA
CCGCCATCCAAGCGCAGATTCAAGCCGAAACCCAGCTGCCGTTTGATTTGCAAACTGGGCCATTATTGCGCGTGCTGTTG
CTGCACATCCGCGATCACGAATATATCAAATTGGTCAGTGTGCATCATAGTGTTTTTGACGGCTGGTCAGCTGGAGTGAT
CATCTCCGAATTGAATCATTTGCTGAATGCGGCCTATGCTGGCGAGCCAAGCAGCTTGCCAGCCTTGCCAATTCAATACG
CCGATTATGCGGTTTGGCAACGCAATTGGCTACAAGGTAAGGTGTTGGAGCAGCAACTGCAATATTGGAAAGAACAACTC
GCTGGCGAATTGCCAATTCTGCAATTACCGACTGATCGGCCTTATCCACCAGTTGAATCGTCGCGTGGCGCACATTATCG
GGTGCAATTGAGTGCCGATTTGGTTGAACGATTGGTCAATTGGAGTCGCAGCGAGGGCTATACACTCAACATTATTTTGC
TCACCATCTGGAAAACCCTGCTCTTTCGTTACACCAACCAAACCGATTTGCTGGTCGGCATGCCGATCGCCAATCGCCAT
TACAACGATTTGCAAGCCTTAATCGGCTATTTCGTCAATACCTTGGTGATTCGCACCAAAGCCGCTGGCGACCTCAGTTT
CCGCAGCTTTTTGGATCAAGTGCGAGCGGCGAATTTGGCAGCGCAAGAGCATCAAGATTTGCCATTTGAGCAATTGGTCG
AGGCTTTGCAGCCTGATCGTAATTTGGCACATACGCCAATTTTTCAAAGCTTGTTTGTGTTTCAGCGCGATACGGTCAAT
AGTTTTCAAATGCCTGAGCTTTCGGTTGAGCCATTGCCAATTGAAACTGGTACGGCCAAGTTTGCCCTTAGCCTTGAAGC
CGTCTCGCTTGATCAGCAAATCAAGCTCAATTTCGAGTATAAAACTGATCTGTTTGATCCAGCGACGATTGAACGCTTGG
CCCAACATTACCAAAATTTACTCGAAGCAGTGCTTGCTTCGCCCGATTTGGAGCTTTCGCGCTTACCCATGTTGGGCAAG
GCTGAGCTAGCCCAATTGTTGCCAACGCCAACAGCGCTCGAAGCAAACTTGTTGCCCTTGCACCAACGCTTTGAGCAGCA
GGTGCAGGCCAATCCGCAAGCGATTGCGGTACGCTTTGAGCAAAGCCAACTAAGCTACGCCGAGCTAAATAGCCGCGCCA
ACCAACTGGCCCATCAACTCAAAACGCTCGACGTTGGCCCAGATACCTTGGTTGGGCTATGTGTTGAGCCATCGCTCGAT
ACAATCATTGGAATTTTGGCAATTCTCAAGGCTGGCGGCGCATATCTGCCGATCGATCCTGCACATCCTCAAGAGCGAAT
TGTTTGGTTGTTGGCTGATGCCAAGGTTGGCTTGGTGGTTACCCAAGCTCGTTGTGTCAACAAATTACCCCAAGCTGGGT
TGCAATTGATTGTGCTTGATGCCGTCGATTCAGCGCTGAGCAATCAGCCAACCAGTAATCTGCCAGCTAGCGCCCAGCTC
GATGACTTGGCCTATATGATTTACACCTCAGGCTCGACTGGCACGCCCAAAGGTGCATTGATCACCCATCGCAACGTGGC
GCGACTGTTTAGTTCAACCGAAGCATGGTTCAACTTCAACAACCACGATGTCTGGAGTTTGTTCCATTCGTTCGCCTTCG
ATTTCTCAGTTTGGGAAATTTGGGGAGCCTTGCTGTATGGTGGTCGCGTGGTCGTCGTGCCATTTATGACCACCCGCAAC
CCCGCTGGCTTCTATCAATTGCTGGTTGATGAAGGCGTGACGGTGCTCAACCAAACGCCCTCGGCCTTCCGCCAATTGAT
CATCAGCGATGCTGAACATGACTTGCCATCGCGCCTAGCCTTGCGTTATGTCATCTTCGGTGGCGAAGCACTGAACGTTG
GGGCATTGCAACCATGGTTCGAGCGCCATGGCGATCTACGCCCGCAGTTAGTCAATATGTATGGCATTACTGAAACCACC
GTCCATGTGACCTACCGACCGCTGAGCATGCACGATGTTGAAAATCCCCAAAGCAGCCCGATTGGCACGGCAATTCCCGA
TTTGGATCTGTATGTGCTTGATGATCATTGTTTGCCAGTGCCATTGGGAATTACTGGCGAACTATATGTGGGCGGCGCGG
GCTTGGCTCGCGGCTATTGGAATCGACCCGAACTAACCAACGAGCGCTTTATCAAGCATCCCTTTGCTGAAACAGGCCGC
CTCTATAAAACTGGCGATTTAGTGCGGCGCTTGGCTAATAATGAGATCGAATATCTGGGGCGGCGTGACAACCAAGTCAA
AATTCGCGGCTTCCGAATTGAGCTAGGCGAAATTCAGGCCACCCTGATGAGCCACCCCGCGATCACCGATGCGATTGTGG
CGGTCAATACAATCTCAGCCGATGATCAGCGCTTGGTGGCCTATTTGGTAACCCAGCCTAATCAAGTGCCACGCTTTAGC
CAATTGCGCACATTTCTCAAGCAACGCCTGCCAGAATATATGGTGCCAACCTCATTCATTATGCTTGAGCGTATTCCGCT
GACTGCCAACGGCAAAATCGATTATCGCGCTTTGCCCAGCCAACAACAGACCAAACAACTTGAGCGCAGCCAACCGATCG
CGGCTCCAACCAGTGTTACCGAGCAATCGTTGATCGCGATTTGGAGCAATTTGCTGGGAGTAACCCAAGTTGGCATTCAG
GATAATTTCTTTGATTTGGGTGGGCACTCATTGTTGGCAACCCAAGTTATTTCACGGGTGCGCGAGGTGTTTAATGTTAG
CCTCAACTTGCGCGATTTCTTCCTCAACCCAACCATCAAGGGCTTAGCCAGCGTTATCGAGCAGGCCAACCAAAAACCAG
AGCAAACGCCAATTATCGCGATTCACAAAGCTGATCCGCAGGCACGTTTGCCACTTTCCTATGCCCAACAGCGCATTTGG
TTCTTGGCTCAAATCGATCCAACCAGCAGTTTTTATACTGTCCCTGTGGCCTTAGAAATTACTGGCCCCTTGCAAGTTGC
CGCTTTAGAACGCACCTTGAGCGAGATTGTGCAGCGCCATCATGGCTTGCGCACCCTGTTTGTGAGCCACGAAGGCCAAA
CGCTTCAGCAAGTCCAAGCAGCTCAGCCAATTCAATTGCCAATTCATGATCTCAGTGATTTAGCTGAGGCAGCCCAAGAA
ACAGCGATCAACCAATTATTGGAGCAGGAGATTAATCAACCCTTCCAGCTTGATCGCGATCAACTGTTGCGCGGGCGCTT
GCTCAAACTAGCTCCAACCAAGCATGTGCTCGGCCTAAGCATTCATCATATTGCCTTTGATGATTGGTCGCAGGGCATTT
TGTTTGATGAAATGACCAAGCTCTACCAGGCCTTTGCCAACAATCAAGCCTCGCCATTGCCCGAGCTAGCTTTGCAATAC
CCTGATTTTGCCGCTTGGCAACGTCAATGGTTGCAAGGCGAAGTTTTACAAAACCAATTGAATTACTGGAAACAGCAATT
GAGTGGCAAATTACCATTGCTCGAAATGCCGCTGGATTACCCACGGCCTAGCGTACAAAGTTTCAATGGCGCACACGAAA
TGCTGAGCATCGAGCCAGAACTGTATCGCAAACTTAATCAATTGGCGCGAGATAACGAAGCAACCATGTTTATGTTGCTG
ATGGCAGCATGGGCGATTTTGCTCAATCGTTATAGCAATCAAACTGATATTGTTATCGGCACGCCAATCGCCAACCGCAA
CCGCCAAGAGCTAGAGGGCATCATCGGGTTCTTTGCGAATACCCTGGCCATTCGCGCCGATTTAACTGGCGATCCAACGC
TTCAACAAGTGGTGCAACGGATTCGCGAAACCGCCCTAAATGGCTATAGCCACCAAGATTTACCGTTCGATTTGTTGGTC
AGCGAGCTTTTGCCTGAACGACAAGCCAATCGCTCACCAATTTTCCAAGCTATGTTGGTGCTGCAAAACGCCTCACAGAG
CAGCAACCTCGATTTGGCCGAGGTGCAGATTGCGCCGCGCAGCGTTGAAACCAACTCGGCTAAGTTTGAGCTAAGTTTGG
TGCTCTACGACAACGGCTCAAGCATCGACGCTTGGATTGAATACAACACCGACCTGTTTAAACCCACCACGATTGGCCGC
ATGGTCGAGCAGTTACAACAATTGCTCACCAGCATGACCACCGATCCACAACAACGCATCAGCCAAGTTTCGTTGGTCAG
TTCGGCAGAAAAAGAACGGCTACTCGGCGGCTGGTCGCAAGGAAGCGACGACGACTACGATTTGTTCTAG

Upstream 100 bases:

>100_bases
AGCGATCACGACCAGATCGCTCAAATACTTGCTGAATTAGAACAACTCTCCACTGATGAGGCTAAATCTCGTCTGGTTGG
GTGAGGTATGGAGATTTCAC

Downstream 100 bases:

>100_bases
ATCTACGTCGATCAAGGGCTGGTTCAGGCCGACCCTTGGTTACGTGTGCAAAGGGTGAAATGGAAATGGATTTTCAGAGT
ATCCAGCGACGTTTTGCAAC

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1569; Mature: 1568

Protein sequence:

>1569_residues
MTDFAAKIAALPPEKQALLIRRLQQAANEPPALVAQPRTTNTLPLSFAQERQWVLYQWDPTSPLYNIVYGVRYRGKLDIA
ALQAGFNTIAQRHEVLRTTFLLVDTVPHQQIHAELKPGFSVVDLRDLAETERDTAIQAQIQAETQLPFDLQTGPLLRVLL
LHIRDHEYIKLVSVHHSVFDGWSAGVIISELNHLLNAAYAGEPSSLPALPIQYADYAVWQRNWLQGKVLEQQLQYWKEQL
AGELPILQLPTDRPYPPVESSRGAHYRVQLSADLVERLVNWSRSEGYTLNIILLTIWKTLLFRYTNQTDLLVGMPIANRH
YNDLQALIGYFVNTLVIRTKAAGDLSFRSFLDQVRAANLAAQEHQDLPFEQLVEALQPDRNLAHTPIFQSLFVFQRDTVN
SFQMPELSVEPLPIETGTAKFALSLEAVSLDQQIKLNFEYKTDLFDPATIERLAQHYQNLLEAVLASPDLELSRLPMLGK
AELAQLLPTPTALEANLLPLHQRFEQQVQANPQAIAVRFEQSQLSYAELNSRANQLAHQLKTLDVGPDTLVGLCVEPSLD
TIIGILAILKAGGAYLPIDPAHPQERIVWLLADAKVGLVVTQARCVNKLPQAGLQLIVLDAVDSALSNQPTSNLPASAQL
DDLAYMIYTSGSTGTPKGALITHRNVARLFSSTEAWFNFNNHDVWSLFHSFAFDFSVWEIWGALLYGGRVVVVPFMTTRN
PAGFYQLLVDEGVTVLNQTPSAFRQLIISDAEHDLPSRLALRYVIFGGEALNVGALQPWFERHGDLRPQLVNMYGITETT
VHVTYRPLSMHDVENPQSSPIGTAIPDLDLYVLDDHCLPVPLGITGELYVGGAGLARGYWNRPELTNERFIKHPFAETGR
LYKTGDLVRRLANNEIEYLGRRDNQVKIRGFRIELGEIQATLMSHPAITDAIVAVNTISADDQRLVAYLVTQPNQVPRFS
QLRTFLKQRLPEYMVPTSFIMLERIPLTANGKIDYRALPSQQQTKQLERSQPIAAPTSVTEQSLIAIWSNLLGVTQVGIQ
DNFFDLGGHSLLATQVISRVREVFNVSLNLRDFFLNPTIKGLASVIEQANQKPEQTPIIAIHKADPQARLPLSYAQQRIW
FLAQIDPTSSFYTVPVALEITGPLQVAALERTLSEIVQRHHGLRTLFVSHEGQTLQQVQAAQPIQLPIHDLSDLAEAAQE
TAINQLLEQEINQPFQLDRDQLLRGRLLKLAPTKHVLGLSIHHIAFDDWSQGILFDEMTKLYQAFANNQASPLPELALQY
PDFAAWQRQWLQGEVLQNQLNYWKQQLSGKLPLLEMPLDYPRPSVQSFNGAHEMLSIEPELYRKLNQLARDNEATMFMLL
MAAWAILLNRYSNQTDIVIGTPIANRNRQELEGIIGFFANTLAIRADLTGDPTLQQVVQRIRETALNGYSHQDLPFDLLV
SELLPERQANRSPIFQAMLVLQNASQSSNLDLAEVQIAPRSVETNSAKFELSLVLYDNGSSIDAWIEYNTDLFKPTTIGR
MVEQLQQLLTSMTTDPQQRISQVSLVSSAEKERLLGGWSQGSDDDYDLF

Sequences:

>Translated_1569_residues
MTDFAAKIAALPPEKQALLIRRLQQAANEPPALVAQPRTTNTLPLSFAQERQWVLYQWDPTSPLYNIVYGVRYRGKLDIA
ALQAGFNTIAQRHEVLRTTFLLVDTVPHQQIHAELKPGFSVVDLRDLAETERDTAIQAQIQAETQLPFDLQTGPLLRVLL
LHIRDHEYIKLVSVHHSVFDGWSAGVIISELNHLLNAAYAGEPSSLPALPIQYADYAVWQRNWLQGKVLEQQLQYWKEQL
AGELPILQLPTDRPYPPVESSRGAHYRVQLSADLVERLVNWSRSEGYTLNIILLTIWKTLLFRYTNQTDLLVGMPIANRH
YNDLQALIGYFVNTLVIRTKAAGDLSFRSFLDQVRAANLAAQEHQDLPFEQLVEALQPDRNLAHTPIFQSLFVFQRDTVN
SFQMPELSVEPLPIETGTAKFALSLEAVSLDQQIKLNFEYKTDLFDPATIERLAQHYQNLLEAVLASPDLELSRLPMLGK
AELAQLLPTPTALEANLLPLHQRFEQQVQANPQAIAVRFEQSQLSYAELNSRANQLAHQLKTLDVGPDTLVGLCVEPSLD
TIIGILAILKAGGAYLPIDPAHPQERIVWLLADAKVGLVVTQARCVNKLPQAGLQLIVLDAVDSALSNQPTSNLPASAQL
DDLAYMIYTSGSTGTPKGALITHRNVARLFSSTEAWFNFNNHDVWSLFHSFAFDFSVWEIWGALLYGGRVVVVPFMTTRN
PAGFYQLLVDEGVTVLNQTPSAFRQLIISDAEHDLPSRLALRYVIFGGEALNVGALQPWFERHGDLRPQLVNMYGITETT
VHVTYRPLSMHDVENPQSSPIGTAIPDLDLYVLDDHCLPVPLGITGELYVGGAGLARGYWNRPELTNERFIKHPFAETGR
LYKTGDLVRRLANNEIEYLGRRDNQVKIRGFRIELGEIQATLMSHPAITDAIVAVNTISADDQRLVAYLVTQPNQVPRFS
QLRTFLKQRLPEYMVPTSFIMLERIPLTANGKIDYRALPSQQQTKQLERSQPIAAPTSVTEQSLIAIWSNLLGVTQVGIQ
DNFFDLGGHSLLATQVISRVREVFNVSLNLRDFFLNPTIKGLASVIEQANQKPEQTPIIAIHKADPQARLPLSYAQQRIW
FLAQIDPTSSFYTVPVALEITGPLQVAALERTLSEIVQRHHGLRTLFVSHEGQTLQQVQAAQPIQLPIHDLSDLAEAAQE
TAINQLLEQEINQPFQLDRDQLLRGRLLKLAPTKHVLGLSIHHIAFDDWSQGILFDEMTKLYQAFANNQASPLPELALQY
PDFAAWQRQWLQGEVLQNQLNYWKQQLSGKLPLLEMPLDYPRPSVQSFNGAHEMLSIEPELYRKLNQLARDNEATMFMLL
MAAWAILLNRYSNQTDIVIGTPIANRNRQELEGIIGFFANTLAIRADLTGDPTLQQVVQRIRETALNGYSHQDLPFDLLV
SELLPERQANRSPIFQAMLVLQNASQSSNLDLAEVQIAPRSVETNSAKFELSLVLYDNGSSIDAWIEYNTDLFKPTTIGR
MVEQLQQLLTSMTTDPQQRISQVSLVSSAEKERLLGGWSQGSDDDYDLF
>Mature_1568_residues
TDFAAKIAALPPEKQALLIRRLQQAANEPPALVAQPRTTNTLPLSFAQERQWVLYQWDPTSPLYNIVYGVRYRGKLDIAA
LQAGFNTIAQRHEVLRTTFLLVDTVPHQQIHAELKPGFSVVDLRDLAETERDTAIQAQIQAETQLPFDLQTGPLLRVLLL
HIRDHEYIKLVSVHHSVFDGWSAGVIISELNHLLNAAYAGEPSSLPALPIQYADYAVWQRNWLQGKVLEQQLQYWKEQLA
GELPILQLPTDRPYPPVESSRGAHYRVQLSADLVERLVNWSRSEGYTLNIILLTIWKTLLFRYTNQTDLLVGMPIANRHY
NDLQALIGYFVNTLVIRTKAAGDLSFRSFLDQVRAANLAAQEHQDLPFEQLVEALQPDRNLAHTPIFQSLFVFQRDTVNS
FQMPELSVEPLPIETGTAKFALSLEAVSLDQQIKLNFEYKTDLFDPATIERLAQHYQNLLEAVLASPDLELSRLPMLGKA
ELAQLLPTPTALEANLLPLHQRFEQQVQANPQAIAVRFEQSQLSYAELNSRANQLAHQLKTLDVGPDTLVGLCVEPSLDT
IIGILAILKAGGAYLPIDPAHPQERIVWLLADAKVGLVVTQARCVNKLPQAGLQLIVLDAVDSALSNQPTSNLPASAQLD
DLAYMIYTSGSTGTPKGALITHRNVARLFSSTEAWFNFNNHDVWSLFHSFAFDFSVWEIWGALLYGGRVVVVPFMTTRNP
AGFYQLLVDEGVTVLNQTPSAFRQLIISDAEHDLPSRLALRYVIFGGEALNVGALQPWFERHGDLRPQLVNMYGITETTV
HVTYRPLSMHDVENPQSSPIGTAIPDLDLYVLDDHCLPVPLGITGELYVGGAGLARGYWNRPELTNERFIKHPFAETGRL
YKTGDLVRRLANNEIEYLGRRDNQVKIRGFRIELGEIQATLMSHPAITDAIVAVNTISADDQRLVAYLVTQPNQVPRFSQ
LRTFLKQRLPEYMVPTSFIMLERIPLTANGKIDYRALPSQQQTKQLERSQPIAAPTSVTEQSLIAIWSNLLGVTQVGIQD
NFFDLGGHSLLATQVISRVREVFNVSLNLRDFFLNPTIKGLASVIEQANQKPEQTPIIAIHKADPQARLPLSYAQQRIWF
LAQIDPTSSFYTVPVALEITGPLQVAALERTLSEIVQRHHGLRTLFVSHEGQTLQQVQAAQPIQLPIHDLSDLAEAAQET
AINQLLEQEINQPFQLDRDQLLRGRLLKLAPTKHVLGLSIHHIAFDDWSQGILFDEMTKLYQAFANNQASPLPELALQYP
DFAAWQRQWLQGEVLQNQLNYWKQQLSGKLPLLEMPLDYPRPSVQSFNGAHEMLSIEPELYRKLNQLARDNEATMFMLLM
AAWAILLNRYSNQTDIVIGTPIANRNRQELEGIIGFFANTLAIRADLTGDPTLQQVVQRIRETALNGYSHQDLPFDLLVS
ELLPERQANRSPIFQAMLVLQNASQSSNLDLAEVQIAPRSVETNSAKFELSLVLYDNGSSIDAWIEYNTDLFKPTTIGRM
VEQLQQLLTSMTTDPQQRISQVSLVSSAEKERLLGGWSQGSDDDYDLF

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=587, Percent_Identity=24.0204429301533, Blast_Score=123, Evalue=1e-27,
Organism=Homo sapiens, GI187761345, Length=534, Percent_Identity=24.3445692883895, Blast_Score=108, Evalue=4e-23,
Organism=Homo sapiens, GI187761343, Length=534, Percent_Identity=24.3445692883895, Blast_Score=108, Evalue=4e-23,
Organism=Homo sapiens, GI28416953, Length=584, Percent_Identity=23.8013698630137, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI38505220, Length=386, Percent_Identity=24.8704663212435, Blast_Score=91, Evalue=1e-17,
Organism=Homo sapiens, GI115511026, Length=406, Percent_Identity=24.6305418719212, Blast_Score=80, Evalue=2e-14,
Organism=Homo sapiens, GI13375727, Length=398, Percent_Identity=21.8592964824121, Blast_Score=79, Evalue=4e-14,
Organism=Homo sapiens, GI122937307, Length=368, Percent_Identity=22.8260869565217, Blast_Score=75, Evalue=6e-13,
Organism=Homo sapiens, GI42544132, Length=512, Percent_Identity=19.921875, Blast_Score=74, Evalue=1e-12,
Organism=Homo sapiens, GI157311624, Length=470, Percent_Identity=20.4255319148936, Blast_Score=71, Evalue=1e-11,
Organism=Homo sapiens, GI157311622, Length=470, Percent_Identity=20.4255319148936, Blast_Score=71, Evalue=1e-11,
Organism=Escherichia coli, GI1786801, Length=1187, Percent_Identity=26.7902274641954, Blast_Score=303, Evalue=8e-83,
Organism=Escherichia coli, GI145693145, Length=526, Percent_Identity=24.5247148288973, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI221142682, Length=503, Percent_Identity=25.2485089463221, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788107, Length=375, Percent_Identity=26.1333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1786810, Length=520, Percent_Identity=26.1538461538462, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1790505, Length=589, Percent_Identity=23.0899830220713, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1789201, Length=379, Percent_Identity=26.9129287598945, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788595, Length=506, Percent_Identity=23.5177865612648, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17550940, Length=1083, Percent_Identity=23.8227146814404, Blast_Score=182, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556356, Length=596, Percent_Identity=24.8322147651007, Blast_Score=152, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32564420, Length=549, Percent_Identity=23.4972677595628, Blast_Score=89, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564422, Length=454, Percent_Identity=24.4493392070485, Blast_Score=89, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=380, Percent_Identity=24.4736842105263, Blast_Score=88, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=385, Percent_Identity=23.8961038961039, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=410, Percent_Identity=23.4146341463415, Blast_Score=70, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=410, Percent_Identity=23.4146341463415, Blast_Score=70, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=902, Percent_Identity=25.9423503325942, Blast_Score=248, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6319699, Length=398, Percent_Identity=22.8643216080402, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648676, Length=650, Percent_Identity=30, Blast_Score=233, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24581924, Length=558, Percent_Identity=24.1935483870968, Blast_Score=95, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667955, Length=395, Percent_Identity=23.5443037974684, Blast_Score=84, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24667959, Length=395, Percent_Identity=23.5443037974684, Blast_Score=84, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24582852, Length=389, Percent_Identity=26.7352185089974, Blast_Score=84, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472339, Length=395, Percent_Identity=23.5443037974684, Blast_Score=84, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 176371; Mature: 176239

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00584 PFKB_KINASES_2 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFAAKIAALPPEKQALLIRRLQQAANEPPALVAQPRTTNTLPLSFAQERQWVLYQWDP
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECC
TSPLYNIVYGVRYRGKLDIAALQAGFNTIAQRHEVLRTTFLLVDTVPHQQIHAELKPGFS
CCHHHHHHHHEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
VVDLRDLAETERDTAIQAQIQAETQLPFDLQTGPLLRVLLLHIRDHEYIKLVSVHHSVFD
EEEHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHC
GWSAGVIISELNHLLNAAYAGEPSSLPALPIQYADYAVWQRNWLQGKVLEQQLQYWKEQL
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGELPILQLPTDRPYPPVESSRGAHYRVQLSADLVERLVNWSRSEGYTLNIILLTIWKTL
CCCCCEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
LFRYTNQTDLLVGMPIANRHYNDLQALIGYFVNTLVIRTKAAGDLSFRSFLDQVRAANLA
HHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
AQEHQDLPFEQLVEALQPDRNLAHTPIFQSLFVFQRDTVNSFQMPELSVEPLPIETGTAK
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
FALSLEAVSLDQQIKLNFEYKTDLFDPATIERLAQHYQNLLEAVLASPDLELSRLPMLGK
EEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCH
AELAQLLPTPTALEANLLPLHQRFEQQVQANPQAIAVRFEQSQLSYAELNSRANQLAHQL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHH
KTLDVGPDTLVGLCVEPSLDTIIGILAILKAGGAYLPIDPAHPQERIVWLLADAKVGLVV
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEECCCEEEEE
TQARCVNKLPQAGLQLIVLDAVDSALSNQPTSNLPASAQLDDLAYMIYTSGSTGTPKGAL
HHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCE
ITHRNVARLFSSTEAWFNFNNHDVWSLFHSFAFDFSVWEIWGALLYGGRVVVVPFMTTRN
EEHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEEEEECCC
PAGFYQLLVDEGVTVLNQTPSAFRQLIISDAEHDLPSRLALRYVIFGGEALNVGALQPWF
CCHHHHHHHHCCCCEECCCHHHHHHHHHHCCCCCCHHHHEEEEEEECCCEECCCCCCHHH
ERHGDLRPQLVNMYGITETTVHVTYRPLSMHDVENPQSSPIGTAIPDLDLYVLDDHCLPV
HHCCCCCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEC
PLGITGELYVGGAGLARGYWNRPELTNERFIKHPFAETGRLYKTGDLVRRLANNEIEYLG
CCCCCCEEEECCCHHHCCCCCCCCCCCCHHHCCCHHHCCCEEEHHHHHHHHHCCCHHHCC
RRDNQVKIRGFRIELGEIQATLMSHPAITDAIVAVNTISADDQRLVAYLVTQPNQVPRFS
CCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHEEEECCCCCCEEEEEEECCCCCCCCHH
QLRTFLKQRLPEYMVPTSFIMLERIPLTANGKIDYRALPSQQQTKQLERSQPIAAPTSVT
HHHHHHHHHCCHHHCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHH
EQSLIAIWSNLLGVTQVGIQDNFFDLGGHSLLATQVISRVREVFNVSLNLRDFFLNPTIK
HHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEECCCHHH
GLASVIEQANQKPEQTPIIAIHKADPQARLPLSYAQQRIWFLAQIDPTSSFYTVPVALEI
HHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHCEEEEEEEECCCCCEEEEEEEEEE
TGPLQVAALERTLSEIVQRHHGLRTLFVSHEGQTLQQVQAAQPIQLPIHDLSDLAEAAQE
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
TAINQLLEQEINQPFQLDRDQLLRGRLLKLAPTKHVLGLSIHHIAFDDWSQGILFDEMTK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEEEEECCCCCCCHHHHHHH
LYQAFANNQASPLPELALQYPDFAAWQRQWLQGEVLQNQLNYWKQQLSGKLPLLEMPLDY
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PRPSVQSFNGAHEMLSIEPELYRKLNQLARDNEATMFMLLMAAWAILLNRYSNQTDIVIG
CCCCHHCCCCCHHHEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
TPIANRNRQELEGIIGFFANTLAIRADLTGDPTLQQVVQRIRETALNGYSHQDLPFDLLV
CCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SELLPERQANRSPIFQAMLVLQNASQSSNLDLAEVQIAPRSVETNSAKFELSLVLYDNGS
HHHCCHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCC
SIDAWIEYNTDLFKPTTIGRMVEQLQQLLTSMTTDPQQRISQVSLVSSAEKERLLGGWSQ
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GSDDDYDLF
CCCCCCCCC
>Mature Secondary Structure 
TDFAAKIAALPPEKQALLIRRLQQAANEPPALVAQPRTTNTLPLSFAQERQWVLYQWDP
CCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECC
TSPLYNIVYGVRYRGKLDIAALQAGFNTIAQRHEVLRTTFLLVDTVPHQQIHAELKPGFS
CCHHHHHHHHEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
VVDLRDLAETERDTAIQAQIQAETQLPFDLQTGPLLRVLLLHIRDHEYIKLVSVHHSVFD
EEEHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHC
GWSAGVIISELNHLLNAAYAGEPSSLPALPIQYADYAVWQRNWLQGKVLEQQLQYWKEQL
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGELPILQLPTDRPYPPVESSRGAHYRVQLSADLVERLVNWSRSEGYTLNIILLTIWKTL
CCCCCEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
LFRYTNQTDLLVGMPIANRHYNDLQALIGYFVNTLVIRTKAAGDLSFRSFLDQVRAANLA
HHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
AQEHQDLPFEQLVEALQPDRNLAHTPIFQSLFVFQRDTVNSFQMPELSVEPLPIETGTAK
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
FALSLEAVSLDQQIKLNFEYKTDLFDPATIERLAQHYQNLLEAVLASPDLELSRLPMLGK
EEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCH
AELAQLLPTPTALEANLLPLHQRFEQQVQANPQAIAVRFEQSQLSYAELNSRANQLAHQL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHH
KTLDVGPDTLVGLCVEPSLDTIIGILAILKAGGAYLPIDPAHPQERIVWLLADAKVGLVV
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEECCCEEEEE
TQARCVNKLPQAGLQLIVLDAVDSALSNQPTSNLPASAQLDDLAYMIYTSGSTGTPKGAL
HHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCE
ITHRNVARLFSSTEAWFNFNNHDVWSLFHSFAFDFSVWEIWGALLYGGRVVVVPFMTTRN
EEHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEEEEECCC
PAGFYQLLVDEGVTVLNQTPSAFRQLIISDAEHDLPSRLALRYVIFGGEALNVGALQPWF
CCHHHHHHHHCCCCEECCCHHHHHHHHHHCCCCCCHHHHEEEEEEECCCEECCCCCCHHH
ERHGDLRPQLVNMYGITETTVHVTYRPLSMHDVENPQSSPIGTAIPDLDLYVLDDHCLPV
HHCCCCCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEC
PLGITGELYVGGAGLARGYWNRPELTNERFIKHPFAETGRLYKTGDLVRRLANNEIEYLG
CCCCCCEEEECCCHHHCCCCCCCCCCCCHHHCCCHHHCCCEEEHHHHHHHHHCCCHHHCC
RRDNQVKIRGFRIELGEIQATLMSHPAITDAIVAVNTISADDQRLVAYLVTQPNQVPRFS
CCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHEEEECCCCCCEEEEEEECCCCCCCCHH
QLRTFLKQRLPEYMVPTSFIMLERIPLTANGKIDYRALPSQQQTKQLERSQPIAAPTSVT
HHHHHHHHHCCHHHCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHH
EQSLIAIWSNLLGVTQVGIQDNFFDLGGHSLLATQVISRVREVFNVSLNLRDFFLNPTIK
HHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEECCCHHH
GLASVIEQANQKPEQTPIIAIHKADPQARLPLSYAQQRIWFLAQIDPTSSFYTVPVALEI
HHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHCEEEEEEEECCCCCEEEEEEEEEE
TGPLQVAALERTLSEIVQRHHGLRTLFVSHEGQTLQQVQAAQPIQLPIHDLSDLAEAAQE
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
TAINQLLEQEINQPFQLDRDQLLRGRLLKLAPTKHVLGLSIHHIAFDDWSQGILFDEMTK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEEEEECCCCCCCHHHHHHH
LYQAFANNQASPLPELALQYPDFAAWQRQWLQGEVLQNQLNYWKQQLSGKLPLLEMPLDY
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PRPSVQSFNGAHEMLSIEPELYRKLNQLARDNEATMFMLLMAAWAILLNRYSNQTDIVIG
CCCCHHCCCCCHHHEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
TPIANRNRQELEGIIGFFANTLAIRADLTGDPTLQQVVQRIRETALNGYSHQDLPFDLLV
CCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SELLPERQANRSPIFQAMLVLQNASQSSNLDLAEVQIAPRSVETNSAKFELSLVLYDNGS
HHHCCHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCC
SIDAWIEYNTDLFKPTTIGRMVEQLQQLLTSMTTDPQQRISQVSLVSSAEKERLLGGWSQ
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GSDDDYDLF
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]