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The map label for this gene is drrB [H]

Identifier: 159898930

GI number: 159898930

Start: 3071595

End: 3072356

Strand: Reverse

Name: drrB [H]

Synonym: Haur_2409

Alternate gene names: 159898930

Gene position: 3072356-3071595 (Counterclockwise)

Preceding gene: 159898931

Following gene: 159898929

Centisome position: 48.41

GC content: 52.62

Gene sequence:

>762_bases
ATGCAATCGCTACGTGATACATGGCTGCTGTTTAAACATTATCTCACCATGACCATGCGCAACCCAGTAATGGTGATTGT
CGGCCTTTTTCAACCAGTGGTGCAATTGTTATTATTTGCACCCTTGTTAGAGCCAATTGCTGGGACTGAGGGCTTTCCCG
AAGGCGGCGCAATCGGAGTTTTTACCCCAGGTTTGCTGGTGATGTTGGGCATTACTGGCTCGTTGTTTGTGGTATTTGGC
TTTATTGCCGAGTTACGGGCGGGCGTGCTTGAGCGCATGCGGGTTACGCCGCTGAGCCGTTTGGCGCTGGTGCTTGGACG
TTTGCTGCGCGATGTCACGATGTTGCTGCTGCAAGCCTTGGTGCTGGTTGGCGTGGCATGGCTGATGGGCTTGCGGGCTG
ATCCTGCTGGCGTAGCACTTTCGCTGTTGATTGTGGTGCTGCTGGGCTTGTTGGTTTCTTCATGCTCATATGCGGTTGCG
CTCATTTTGCAGGATGAAAACACAGTTGCCTCGTTGCTCAACTTTTTGATCTTGCCAATTTTGCTGCTTTCAGGCATTAC
CCTACCGCTCACTTTAGCGCCCGATTGGATTCGCAATGTCGCGGGAGTTAATCCATTTGCCTATGCTGTTGATGCCTCGC
GGGCCTTGTTTATTGGCCAACTTGAGCATCCGGCGGTTTGGCAAGGCTTTGCAGTGATGGGCGTATTGTCGTTCTTGGGT
GTTTTTTGGGCGGTGCGCTCCTTTCGTCAAGGCGTGGCCTAG

Upstream 100 bases:

>100_bases
TTCAAACCGTCGAACTTTCGCGCCCTTCGCTGGATGATGTTTTTCTTAAGCAAACTGGTCGTTCATTACGCGAGTCTGCC
AACTAGCTCGAGGATATTCA

Downstream 100 bases:

>100_bases
TTGCGCTCCCTCACCCCCTAGCCCCCTCTCCCGCCCGCGAGGCGAGGGGGAACCATCAAACCAAACGCCCCTCGCCCACC
GCAATGCGAGAAGGATTAGG

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MQSLRDTWLLFKHYLTMTMRNPVMVIVGLFQPVVQLLLFAPLLEPIAGTEGFPEGGAIGVFTPGLLVMLGITGSLFVVFG
FIAELRAGVLERMRVTPLSRLALVLGRLLRDVTMLLLQALVLVGVAWLMGLRADPAGVALSLLIVVLLGLLVSSCSYAVA
LILQDENTVASLLNFLILPILLLSGITLPLTLAPDWIRNVAGVNPFAYAVDASRALFIGQLEHPAVWQGFAVMGVLSFLG
VFWAVRSFRQGVA

Sequences:

>Translated_253_residues
MQSLRDTWLLFKHYLTMTMRNPVMVIVGLFQPVVQLLLFAPLLEPIAGTEGFPEGGAIGVFTPGLLVMLGITGSLFVVFG
FIAELRAGVLERMRVTPLSRLALVLGRLLRDVTMLLLQALVLVGVAWLMGLRADPAGVALSLLIVVLLGLLVSSCSYAVA
LILQDENTVASLLNFLILPILLLSGITLPLTLAPDWIRNVAGVNPFAYAVDASRALFIGQLEHPAVWQGFAVMGVLSFLG
VFWAVRSFRQGVA
>Mature_253_residues
MQSLRDTWLLFKHYLTMTMRNPVMVIVGLFQPVVQLLLFAPLLEPIAGTEGFPEGGAIGVFTPGLLVMLGITGSLFVVFG
FIAELRAGVLERMRVTPLSRLALVLGRLLRDVTMLLLQALVLVGVAWLMGLRADPAGVALSLLIVVLLGLLVSSCSYAVA
LILQDENTVASLLNFLILPILLLSGITLPLTLAPDWIRNVAGVNPFAYAVDASRALFIGQLEHPAVWQGFAVMGVLSFLG
VFWAVRSFRQGVA

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 27306; Mature: 27306

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLRDTWLLFKHYLTMTMRNPVMVIVGLFQPVVQLLLFAPLLEPIAGTEGFPEGGAIGV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FTPGLLVMLGITGSLFVVFGFIAELRAGVLERMRVTPLSRLALVLGRLLRDVTMLLLQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VLVGVAWLMGLRADPAGVALSLLIVVLLGLLVSSCSYAVALILQDENTVASLLNFLILPI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
LLLSGITLPLTLAPDWIRNVAGVNPFAYAVDASRALFIGQLEHPAVWQGFAVMGVLSFLG
HHHCCCCCEEEECHHHHHHHCCCCHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHH
VFWAVRSFRQGVA
HHHHHHHHHHCCC
>Mature Secondary Structure
MQSLRDTWLLFKHYLTMTMRNPVMVIVGLFQPVVQLLLFAPLLEPIAGTEGFPEGGAIGV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FTPGLLVMLGITGSLFVVFGFIAELRAGVLERMRVTPLSRLALVLGRLLRDVTMLLLQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VLVGVAWLMGLRADPAGVALSLLIVVLLGLLVSSCSYAVALILQDENTVASLLNFLILPI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
LLLSGITLPLTLAPDWIRNVAGVNPFAYAVDASRALFIGQLEHPAVWQGFAVMGVLSFLG
HHHCCCCCEEEECHHHHHHHCCCCHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHH
VFWAVRSFRQGVA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]