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The map label for this gene is kbl [C]

Identifier: 159898819

GI number: 159898819

Start: 2938535

End: 2939722

Strand: Direct

Name: kbl [C]

Synonym: Haur_2298

Alternate gene names: 159898819

Gene position: 2938535-2939722 (Clockwise)

Preceding gene: 159898817

Following gene: 159898820

Centisome position: 46.3

GC content: 51.77

Gene sequence:

>1188_bases
ATGCCGCATTCATTTGAAGCATATCTTGATGAGCAACTGAATAGTTTGCGTGAGCAGGGGGTTTTTCGCACATTGCGCGA
ATTGCAAAGCCCAACTGGCCCACGCTCAACCATCGATGGCAAATCGGTGATCAATCTCTCATCAAATAATTATTTGGGCT
TGGCTAATCATCCCGCCTTGAAAGCCGCCGCAATCAAAGCAATCGAGGAATGGGGCGTTGGTTCAGGCGCAGTTCGCACA
ATTATTGGCACCATGAGCATCCACGAGGAGCTTGAACAACGCTTAACTGAATTCAAGCATACCGAAGCGGTGTTGGTGCT
GCAATCGGGATTTACTGCCAATGCTGCTGTGTTGGGCGTTGTGCTCAACGATGGCGATTTGGTGATCAGTGATGCACTAA
ATCATGCCTCGATCATCGATGGAATTCGCCTCACCAAAGCGGCGCGGGCGGTCTATCAACACAATGATATGGACGATTTG
GAACGGGTTTTGCAGGCCAACCAAGGCAAATATCGCAACACGGTAATTGTGACCGACGGCGTATTTAGCATGGATGGTGA
TATTGCGCCCTTGCCACGCATCGCCGAGCTAGCCGAGCATTACGGTGCAATCACCATGGTCGATGATGCCCACGCTTCGG
GCGTGTTGGGCAAAAATGGCAGCGGCACAGTCAGCCATTATGGCATCAACCATTGGGATATTCAGGTTGGTACGCTTTCC
AAGGCAATTGGCGCGGTTGGCGGCTACGTTGCCACATCGAGCAAATTACGCCAATTGATGGAGCATCGCGCCCGACCATT
TTTATTCAGCACCTCGCACCCACCAGCGGTTGTTGCCAGCTGTTTGGCGGCCATCAAACTGCTGCAAAGTGCCGAGGGCG
AGCAATTGCACCAACAACTTTGGGAAAATACCAAATTTTTCAAGGCTGGGTTGAACAAGCTTGGTTTCAACACTGGCATC
TCTGAAACCCCGATTACCCCCGTAATTGTGGGCGATGGAGCCAAGTCGATGCAATTCTCCAATGCGTTGTTCCAAGCAGG
CGTATTTGCCCAAGGCATCGCCTTCCCAACCGTGGCGCGAGACAAAGGGCGGGTGCGCACAATCGTCACTGCCAGCCATA
GCAACGCCGATCTAGCTGAAGCCCTCAACATCTTCGAACATGTTGGACGGAGCATGCAGCTAATTTAA

Upstream 100 bases:

>100_bases
TCCATAAGCCGCAGCAACAAATGCCGCTTATGCACTATAATGCATCTGAACCAGATGGCGTTTGGTCATCGGTGCAACTA
GCGTGTTATTGGGGGCGATG

Downstream 100 bases:

>100_bases
GGTTTCATGGTACACTGGAAGCAGAAAATACAGTTCTAGAAATGTGGAGGTCCACCTATCGAAGCGCAAGTTCTTGCCCG
CCGTGCTGTTGATTTAGCAG

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MPHSFEAYLDEQLNSLREQGVFRTLRELQSPTGPRSTIDGKSVINLSSNNYLGLANHPALKAAAIKAIEEWGVGSGAVRT
IIGTMSIHEELEQRLTEFKHTEAVLVLQSGFTANAAVLGVVLNDGDLVISDALNHASIIDGIRLTKAARAVYQHNDMDDL
ERVLQANQGKYRNTVIVTDGVFSMDGDIAPLPRIAELAEHYGAITMVDDAHASGVLGKNGSGTVSHYGINHWDIQVGTLS
KAIGAVGGYVATSSKLRQLMEHRARPFLFSTSHPPAVVASCLAAIKLLQSAEGEQLHQQLWENTKFFKAGLNKLGFNTGI
SETPITPVIVGDGAKSMQFSNALFQAGVFAQGIAFPTVARDKGRVRTIVTASHSNADLAEALNIFEHVGRSMQLI

Sequences:

>Translated_395_residues
MPHSFEAYLDEQLNSLREQGVFRTLRELQSPTGPRSTIDGKSVINLSSNNYLGLANHPALKAAAIKAIEEWGVGSGAVRT
IIGTMSIHEELEQRLTEFKHTEAVLVLQSGFTANAAVLGVVLNDGDLVISDALNHASIIDGIRLTKAARAVYQHNDMDDL
ERVLQANQGKYRNTVIVTDGVFSMDGDIAPLPRIAELAEHYGAITMVDDAHASGVLGKNGSGTVSHYGINHWDIQVGTLS
KAIGAVGGYVATSSKLRQLMEHRARPFLFSTSHPPAVVASCLAAIKLLQSAEGEQLHQQLWENTKFFKAGLNKLGFNTGI
SETPITPVIVGDGAKSMQFSNALFQAGVFAQGIAFPTVARDKGRVRTIVTASHSNADLAEALNIFEHVGRSMQLI
>Mature_394_residues
PHSFEAYLDEQLNSLREQGVFRTLRELQSPTGPRSTIDGKSVINLSSNNYLGLANHPALKAAAIKAIEEWGVGSGAVRTI
IGTMSIHEELEQRLTEFKHTEAVLVLQSGFTANAAVLGVVLNDGDLVISDALNHASIIDGIRLTKAARAVYQHNDMDDLE
RVLQANQGKYRNTVIVTDGVFSMDGDIAPLPRIAELAEHYGAITMVDDAHASGVLGKNGSGTVSHYGINHWDIQVGTLSK
AIGAVGGYVATSSKLRQLMEHRARPFLFSTSHPPAVVASCLAAIKLLQSAEGEQLHQQLWENTKFFKAGLNKLGFNTGIS
ETPITPVIVGDGAKSMQFSNALFQAGVFAQGIAFPTVARDKGRVRTIVTASHSNADLAEALNIFEHVGRSMQLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=40.6735751295337, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI284448556, Length=412, Percent_Identity=38.1067961165049, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI83977442, Length=343, Percent_Identity=35.8600583090379, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI83977440, Length=343, Percent_Identity=35.8600583090379, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI83977444, Length=343, Percent_Identity=35.8600583090379, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=32.4324324324324, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4502025, Length=390, Percent_Identity=33.8461538461538, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI40316939, Length=390, Percent_Identity=33.8461538461538, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=29.4594594594595, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=33.203125, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1790046, Length=400, Percent_Identity=40.5, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=33.7175792507205, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=39.7984886649874, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=29.4765840220386, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=28.2191780821918, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=28.2191780821918, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71982625, Length=263, Percent_Identity=25.8555133079848, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=263, Percent_Identity=25.8555133079848, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=32.7014218009479, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=29.6195652173913, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323954, Length=260, Percent_Identity=29.6153846153846, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24662918, Length=392, Percent_Identity=40.8163265306122, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI17137420, Length=408, Percent_Identity=34.8039215686275, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=31.9034852546917, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653280, Length=301, Percent_Identity=27.5747508305648, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653276, Length=301, Percent_Identity=27.5747508305648, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653278, Length=301, Percent_Identity=27.5747508305648, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42485; Mature: 42354

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSFEAYLDEQLNSLREQGVFRTLRELQSPTGPRSTIDGKSVINLSSNNYLGLANHPAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCHH
KAAAIKAIEEWGVGSGAVRTIIGTMSIHEELEQRLTEFKHTEAVLVLQSGFTANAAVLGV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEE
VLNDGDLVISDALNHASIIDGIRLTKAARAVYQHNDMDDLERVLQANQGKYRNTVIVTDG
EECCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECC
VFSMDGDIAPLPRIAELAEHYGAITMVDDAHASGVLGKNGSGTVSHYGINHWDIQVGTLS
EEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEHHHHH
KAIGAVGGYVATSSKLRQLMEHRARPFLFSTSHPPAVVASCLAAIKLLQSAEGEQLHQQL
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
WENTKFFKAGLNKLGFNTGISETPITPVIVGDGAKSMQFSNALFQAGVFAQGIAFPTVAR
HHCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DKGRVRTIVTASHSNADLAEALNIFEHVGRSMQLI
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PHSFEAYLDEQLNSLREQGVFRTLRELQSPTGPRSTIDGKSVINLSSNNYLGLANHPAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCHH
KAAAIKAIEEWGVGSGAVRTIIGTMSIHEELEQRLTEFKHTEAVLVLQSGFTANAAVLGV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEE
VLNDGDLVISDALNHASIIDGIRLTKAARAVYQHNDMDDLERVLQANQGKYRNTVIVTDG
EECCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECC
VFSMDGDIAPLPRIAELAEHYGAITMVDDAHASGVLGKNGSGTVSHYGINHWDIQVGTLS
EEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEHHHHH
KAIGAVGGYVATSSKLRQLMEHRARPFLFSTSHPPAVVASCLAAIKLLQSAEGEQLHQQL
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
WENTKFFKAGLNKLGFNTGISETPITPVIVGDGAKSMQFSNALFQAGVFAQGIAFPTVAR
HHCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DKGRVRTIVTASHSNADLAEALNIFEHVGRSMQLI
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA