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The map label for this gene is hisD [H]

Identifier: 159898537

GI number: 159898537

Start: 2502613

End: 2503947

Strand: Direct

Name: hisD [H]

Synonym: Haur_2013

Alternate gene names: 159898537

Gene position: 2502613-2503947 (Clockwise)

Preceding gene: 159898535

Following gene: 159898539

Centisome position: 39.43

GC content: 53.03

Gene sequence:

>1335_bases
ATGCCAATTCAGCTTTATACCGATCTTGCGCAGGCTCAACAAGGCCCATTAGCACGAGTCGCCTTCGATACGGTCGAAGT
TCCAGAGCGTTTACAACAAAGCCTCGACCACATGTTTGGGGTTGGCACAACGCCTGCCGCTGCGGTTGATCAGATCTTAG
CCAGTGTGCGGCGCGATGGCGATGCGGCCTTAGAGCACTGGAGCCGCACGATCGAAGGCGTTGAATTAAGCCAATTTGAG
GTCGATCGCTCGGCGATTGAAGCCGCCTATAGCCAACTTGATCCATTATTGGTTGAAGCGTTACGGATCTCTGCTGCCGA
GATCGAGCGTTTTCATCGTAAGCAAACCCGCCAAAGTTGGGTTGATTGGTCGGATGAAGGAGCACTGGGTCAGATTGTTC
TACCACTTGAGCGGATTGGGGCGTATGCGCCAGGTGGCACAGCTCCCCTTCCATCGTCATTATTGATGGGGGTAATTCCA
GCTAAGGTAGCTGGAGTACGCGAGATTATTGTGTGCTCGCCGCCGCAACGTGATACTGGCGAGATCTCGCCGTTGGTCTT
GGTAGCTGCCGATATTGCTGGAGTCCACCGAATTTTTCGTTTGGGCGGGGCACAGGCCATTGCTGCGATGGCCTATGGCA
CGAATAGTGTGCCACATGTCGATAAAATTATCGGTCCAGGCAATCTGTTTGTGGTGTTGGCCAAAAAGGCGGTGTATGGC
ACGGTTGATATTGAAGCCTTGCCCGGCCCTACCGAAACCATGGTGATTGCCGATGCTGATGCTAACCCTGAGCTAGTGGC
TGCCGATTTACTCGCCCAAGCCGAACATGATTTGCTGGCTTCGGCGATTTTGCTTACGCCTTCGTTGGAATTGGCCGAAA
AAGTCCAGGTCGCGGTTGCTCGTCAACTCGAAGAGCTTGAACGAGCTGAAATCGCGGCCCAAGCGCTCACCAATCGCTCA
GGGATTGTGCTTGTCCCTTCATTAGAGGTTGCATTCGATTTAAGTAATGCCTATGGCCCTGAGCACCTCTGTTTATTAGT
CAACGATCCTTGGCAATATGTGGGTAAAGTACGCAATGCTGGGGGCATTTTCCTTGGTGAACGTTCGTTTGAAGTGTTGG
GTGATTATGTGGCTGGGCCATCGCACATTATGCCCACTGGTGGTACGGCTCGCTATGCCTCGCCAGTCAATGTTGACCAC
TTCCGAAAAGTTATTTCGTTGGTTGGCTTGAACGAAAAAGCCTTGCAACGATTAGGGCCAGTCGCTCAGCGTTTGGCTGA
GGCCGAAGGACTGACCGCCCATGCGGCGGCTGTACGCCGCCGTTTAGAGCAATAA

Upstream 100 bases:

>100_bases
AGCATCTGGATCACCATTGTGCTGCCATGCTTCGCCTTCATTTGCGCTCAACGCCGAATTTGGTAGCATGCTGCTAGTTC
ATTGGATAGATGGAGCATAC

Downstream 100 bases:

>100_bases
TGTCGTTTATCAGTGGATACTTCTCTTGTGCTTTGTGATAGGCCAAAACGGCTGCGGGGTGCGAGACCAGCAAGCCTACC
TTGTATTGCTGGCATCCACT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPIQLYTDLAQAQQGPLARVAFDTVEVPERLQQSLDHMFGVGTTPAAAVDQILASVRRDGDAALEHWSRTIEGVELSQFE
VDRSAIEAAYSQLDPLLVEALRISAAEIERFHRKQTRQSWVDWSDEGALGQIVLPLERIGAYAPGGTAPLPSSLLMGVIP
AKVAGVREIIVCSPPQRDTGEISPLVLVAADIAGVHRIFRLGGAQAIAAMAYGTNSVPHVDKIIGPGNLFVVLAKKAVYG
TVDIEALPGPTETMVIADADANPELVAADLLAQAEHDLLASAILLTPSLELAEKVQVAVARQLEELERAEIAAQALTNRS
GIVLVPSLEVAFDLSNAYGPEHLCLLVNDPWQYVGKVRNAGGIFLGERSFEVLGDYVAGPSHIMPTGGTARYASPVNVDH
FRKVISLVGLNEKALQRLGPVAQRLAEAEGLTAHAAAVRRRLEQ

Sequences:

>Translated_444_residues
MPIQLYTDLAQAQQGPLARVAFDTVEVPERLQQSLDHMFGVGTTPAAAVDQILASVRRDGDAALEHWSRTIEGVELSQFE
VDRSAIEAAYSQLDPLLVEALRISAAEIERFHRKQTRQSWVDWSDEGALGQIVLPLERIGAYAPGGTAPLPSSLLMGVIP
AKVAGVREIIVCSPPQRDTGEISPLVLVAADIAGVHRIFRLGGAQAIAAMAYGTNSVPHVDKIIGPGNLFVVLAKKAVYG
TVDIEALPGPTETMVIADADANPELVAADLLAQAEHDLLASAILLTPSLELAEKVQVAVARQLEELERAEIAAQALTNRS
GIVLVPSLEVAFDLSNAYGPEHLCLLVNDPWQYVGKVRNAGGIFLGERSFEVLGDYVAGPSHIMPTGGTARYASPVNVDH
FRKVISLVGLNEKALQRLGPVAQRLAEAEGLTAHAAAVRRRLEQ
>Mature_443_residues
PIQLYTDLAQAQQGPLARVAFDTVEVPERLQQSLDHMFGVGTTPAAAVDQILASVRRDGDAALEHWSRTIEGVELSQFEV
DRSAIEAAYSQLDPLLVEALRISAAEIERFHRKQTRQSWVDWSDEGALGQIVLPLERIGAYAPGGTAPLPSSLLMGVIPA
KVAGVREIIVCSPPQRDTGEISPLVLVAADIAGVHRIFRLGGAQAIAAMAYGTNSVPHVDKIIGPGNLFVVLAKKAVYGT
VDIEALPGPTETMVIADADANPELVAADLLAQAEHDLLASAILLTPSLELAEKVQVAVARQLEELERAEIAAQALTNRSG
IVLVPSLEVAFDLSNAYGPEHLCLLVNDPWQYVGKVRNAGGIFLGERSFEVLGDYVAGPSHIMPTGGTARYASPVNVDHF
RKVISLVGLNEKALQRLGPVAQRLAEAEGLTAHAAAVRRRLEQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=40.5, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=38.9705882352941, Blast_Score=263, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47476; Mature: 47345

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQLYTDLAQAQQGPLARVAFDTVEVPERLQQSLDHMFGVGTTPAAAVDQILASVRRDG
CCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
DAALEHWSRTIEGVELSQFEVDRSAIEAAYSQLDPLLVEALRISAAEIERFHRKQTRQSW
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDWSDEGALGQIVLPLERIGAYAPGGTAPLPSSLLMGVIPAKVAGVREIIVCSPPQRDTG
CCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCC
EISPLVLVAADIAGVHRIFRLGGAQAIAAMAYGTNSVPHVDKIIGPGNLFVVLAKKAVYG
CCCHHEEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECHHEEE
TVDIEALPGPTETMVIADADANPELVAADLLAQAEHDLLASAILLTPSLELAEKVQVAVA
EEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RQLEELERAEIAAQALTNRSGIVLVPSLEVAFDLSNAYGPEHLCLLVNDPWQYVGKVRNA
HHHHHHHHHHHHHHHHCCCCCEEEEECHHEEEECCCCCCCCEEEEEECCCHHHHHHHCCC
GGIFLGERSFEVLGDYVAGPSHIMPTGGTARYASPVNVDHFRKVISLVGLNEKALQRLGP
CCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
VAQRLAEAEGLTAHAAAVRRRLEQ
HHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PIQLYTDLAQAQQGPLARVAFDTVEVPERLQQSLDHMFGVGTTPAAAVDQILASVRRDG
CCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
DAALEHWSRTIEGVELSQFEVDRSAIEAAYSQLDPLLVEALRISAAEIERFHRKQTRQSW
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDWSDEGALGQIVLPLERIGAYAPGGTAPLPSSLLMGVIPAKVAGVREIIVCSPPQRDTG
CCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCC
EISPLVLVAADIAGVHRIFRLGGAQAIAAMAYGTNSVPHVDKIIGPGNLFVVLAKKAVYG
CCCHHEEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECHHEEE
TVDIEALPGPTETMVIADADANPELVAADLLAQAEHDLLASAILLTPSLELAEKVQVAVA
EEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RQLEELERAEIAAQALTNRSGIVLVPSLEVAFDLSNAYGPEHLCLLVNDPWQYVGKVRNA
HHHHHHHHHHHHHHHHCCCCCEEEEECHHEEEECCCCCCCCEEEEEECCCHHHHHHHCCC
GGIFLGERSFEVLGDYVAGPSHIMPTGGTARYASPVNVDHFRKVISLVGLNEKALQRLGP
CCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
VAQRLAEAEGLTAHAAAVRRRLEQ
HHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]