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The map label for this gene is hpd [H]

Identifier: 159898412

GI number: 159898412

Start: 2276722

End: 2277822

Strand: Reverse

Name: hpd [H]

Synonym: Haur_1888

Alternate gene names: 159898412

Gene position: 2277822-2276722 (Counterclockwise)

Preceding gene: 159898413

Following gene: 159898411

Centisome position: 35.89

GC content: 50.14

Gene sequence:

>1101_bases
ATGACTAGCCCAACATCACTAGACACCACGCCGCAACTCGACGATTTCGATTACGTTGAATTCTATGTTGGAAATGCTCG
TCAGACTGCCCACTTTTTACGCACCGCCTTTGGCTTCAAACCAATTGCCTACGCTGGACTCGAAACAGGCGTACGCGATC
GCGCCTCGATTTTGCTGCAACAAGGTGCGATTCGCCTGATCATCACCGAAGCACTCGACCCTGAAAGCCCAATCGCCGAC
CACGTAAAATTGCATGGCGATAGTATTAAGGATATTGCCTTTACGGTTGCCAATGTGCATAGCGCCTTCGAGGCCGCCGT
TAAACGTGGTGCCCGCCCAATCTTAGAACCAGTGACAATCGAAAGCCCCCAAGGAAGCATCATCAAGGCCACCATTGGCA
CCTATGGTGATACAACCCACTCATTGATCCAGCGAGTCGATCTTGCTGATAATGCTTTCCCCCAATTTCAGCCAATCGAA
AATCCGGCTCACGTAATTGATGGCGGCTTCTCAGTCGTCGATCACGTTGCGATTAGCCTAGAGCCAGGTCGCTTGGCCGA
ATGGGTCGATTTCTACATCAATGTGCTTGGTTTCCATCAATCGCACGAAGAAAATATTGTTACCGAATATAGTGGCATGA
ACTCGCGGGTCGTCCAGAACCACGCTGGCACGATTAAATTCCCTATGCAAGAGCCGATTCAAGGCAAACGGCGTTCGCAA
GTTGAAGAATTCTTGACCTTTCATCATGGAGCCGGAGCCCAGCACTTGGCCATCCTCACTGATGATATTATTCACTCGAT
CCAGACGCTGCGGGCCAACGGAATCGAGTTTGTGCGCACGCCCGCAACCTACTATGAAAATCTCCAAGAGCGGGTTGGCT
TAATTGATGAAGATATTGCGATGCTGCGCGATTTGCATATTTTGGTAGATCGCGATAGCTCGGGCTATTTGCTGCAAATT
TTCACCAAGCCGCTGCAAAGCCGACCAACGATGTTCTTTGAAATTATTCAGCGCAAAAATGCCATTGGCTTCGGCAGTGG
CAACATCAAAGCACTCTTTGCCGCCGTCGAACGCGAGCAAGCTTTGCGGGGAAATCTCTAA

Upstream 100 bases:

>100_bases
GGCAGATTATCGCTATCCTAAGCGCTGGCATAGTTCGGATGATCGATCGGCACATTTCCAATTATGGCACTCATTTCATC
GTTTCTAGGGAGATGACCTT

Downstream 100 bases:

>100_bases
TGGCTGCGATTGCAACAACTCCTAGCCAATTTGAACTCGCTGCTTGGGCTAAGACCATCACACCCTCGGCGCTGCAAGAT
ATGCTTTCGGCAACTGCCAA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTSPTSLDTTPQLDDFDYVEFYVGNARQTAHFLRTAFGFKPIAYAGLETGVRDRASILLQQGAIRLIITEALDPESPIAD
HVKLHGDSIKDIAFTVANVHSAFEAAVKRGARPILEPVTIESPQGSIIKATIGTYGDTTHSLIQRVDLADNAFPQFQPIE
NPAHVIDGGFSVVDHVAISLEPGRLAEWVDFYINVLGFHQSHEENIVTEYSGMNSRVVQNHAGTIKFPMQEPIQGKRRSQ
VEEFLTFHHGAGAQHLAILTDDIIHSIQTLRANGIEFVRTPATYYENLQERVGLIDEDIAMLRDLHILVDRDSSGYLLQI
FTKPLQSRPTMFFEIIQRKNAIGFGSGNIKALFAAVEREQALRGNL

Sequences:

>Translated_366_residues
MTSPTSLDTTPQLDDFDYVEFYVGNARQTAHFLRTAFGFKPIAYAGLETGVRDRASILLQQGAIRLIITEALDPESPIAD
HVKLHGDSIKDIAFTVANVHSAFEAAVKRGARPILEPVTIESPQGSIIKATIGTYGDTTHSLIQRVDLADNAFPQFQPIE
NPAHVIDGGFSVVDHVAISLEPGRLAEWVDFYINVLGFHQSHEENIVTEYSGMNSRVVQNHAGTIKFPMQEPIQGKRRSQ
VEEFLTFHHGAGAQHLAILTDDIIHSIQTLRANGIEFVRTPATYYENLQERVGLIDEDIAMLRDLHILVDRDSSGYLLQI
FTKPLQSRPTMFFEIIQRKNAIGFGSGNIKALFAAVEREQALRGNL
>Mature_365_residues
TSPTSLDTTPQLDDFDYVEFYVGNARQTAHFLRTAFGFKPIAYAGLETGVRDRASILLQQGAIRLIITEALDPESPIADH
VKLHGDSIKDIAFTVANVHSAFEAAVKRGARPILEPVTIESPQGSIIKATIGTYGDTTHSLIQRVDLADNAFPQFQPIEN
PAHVIDGGFSVVDHVAISLEPGRLAEWVDFYINVLGFHQSHEENIVTEYSGMNSRVVQNHAGTIKFPMQEPIQGKRRSQV
EEFLTFHHGAGAQHLAILTDDIIHSIQTLRANGIEFVRTPATYYENLQERVGLIDEDIAMLRDLHILVDRDSSGYLLQIF
TKPLQSRPTMFFEIIQRKNAIGFGSGNIKALFAAVEREQALRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=366, Percent_Identity=40.9836065573771, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI285002264, Length=345, Percent_Identity=40.5797101449275, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI14249394, Length=363, Percent_Identity=26.9972451790634, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555220, Length=366, Percent_Identity=43.1693989071038, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17550752, Length=368, Percent_Identity=36.4130434782609, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24667510, Length=382, Percent_Identity=41.6230366492147, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI21356105, Length=294, Percent_Identity=42.8571428571429, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40656; Mature: 40524

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPTSLDTTPQLDDFDYVEFYVGNARQTAHFLRTAFGFKPIAYAGLETGVRDRASILLQ
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
QGAIRLIITEALDPESPIADHVKLHGDSIKDIAFTVANVHSAFEAAVKRGARPILEPVTI
CCCEEEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ESPQGSIIKATIGTYGDTTHSLIQRVDLADNAFPQFQPIENPAHVIDGGFSVVDHVAISL
ECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHEEEEE
EPGRLAEWVDFYINVLGFHQSHEENIVTEYSGMNSRVVQNHAGTIKFPMQEPIQGKRRSQ
CCCHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCHHHHCCCCEEECCCCCCCCCHHHHH
VEEFLTFHHGAGAQHLAILTDDIIHSIQTLRANGIEFVRTPATYYENLQERVGLIDEDIA
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCHHHHH
MLRDLHILVDRDSSGYLLQIFTKPLQSRPTMFFEIIQRKNAIGFGSGNIKALFAAVEREQ
HHHHEEEEEECCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALRGNL
HHCCCC
>Mature Secondary Structure 
TSPTSLDTTPQLDDFDYVEFYVGNARQTAHFLRTAFGFKPIAYAGLETGVRDRASILLQ
CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
QGAIRLIITEALDPESPIADHVKLHGDSIKDIAFTVANVHSAFEAAVKRGARPILEPVTI
CCCEEEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ESPQGSIIKATIGTYGDTTHSLIQRVDLADNAFPQFQPIENPAHVIDGGFSVVDHVAISL
ECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHEEEEE
EPGRLAEWVDFYINVLGFHQSHEENIVTEYSGMNSRVVQNHAGTIKFPMQEPIQGKRRSQ
CCCHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCHHHHCCCCEEECCCCCCCCCHHHHH
VEEFLTFHHGAGAQHLAILTDDIIHSIQTLRANGIEFVRTPATYYENLQERVGLIDEDIA
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCHHHHH
MLRDLHILVDRDSSGYLLQIFTKPLQSRPTMFFEIIQRKNAIGFGSGNIKALFAAVEREQ
HHHHEEEEEECCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALRGNL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]