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The map label for this gene is trpA

Identifier: 159898217

GI number: 159898217

Start: 1967519

End: 1968334

Strand: Direct

Name: trpA

Synonym: Haur_1693

Alternate gene names: 159898217

Gene position: 1967519-1968334 (Clockwise)

Preceding gene: 159898216

Following gene: 159898218

Centisome position: 31.0

GC content: 53.43

Gene sequence:

>816_bases
ATGAGCCGAATTGCCCAAACTTTTGAACGCTTAGCCAGCCAAGGTCGGACAGCCCTGATGCCATTTTTGACGATTGGCTA
CCCTGAGCGTGATTCTGCCCTGAGTTTAGCCCAAGCCTTGGTTGCTGGCGGCGCAGATATGCTTGAGCTTGGCATGCCCT
TTTCTGATCCGTTGGCCGATGGCGCGACGATTCAACGTACCACCGATATTGCCCTAACCAATGGAGTGGATATTGGGTTT
TGTTTGGAGACGGTGCGCCAATTACGAGCGACTGGCATGAGCATTCCGTTATTGCTGATGGGCTATTTCAACCCTATGTT
TCAATATGGCGTTGAACGGTTTGTGGCCGAAGCTAAAGCGGCGGGTGCTGATGGTTTTATCGTGCCTGATTTACCACCTG
AGGAGGCCGACGAATTTCATGCTGCGGCCAAAGCCCATGAGTTGGATTTGGTGTTCTTGTTGGCTCCAACCTCGACTGAT
GCCCGTATCGCCAAGATTGCCAGCCTGTCGTCGGGGTTTATCTACTGTGTGGCATTGCGCGGCGTAACTGGTGCGCGGGC
TGCGTTGGCAGACGATTTGGGTGATTTCTTGGCGCGAGTACGCCAATATAGCCAATTGCCGCGTGCGGTTGGCTTTGGCA
TCTCCAAACCTGAACATGTGGCCGCAGTTGCCAAAATGGCTGAAGGGGCAATTTGCGCCAGTGCCTTGCTCGATTATATT
GGCAATTTGCCCGCCGAAGAGCGTGCTACTGGAGCGCAACAGTTTGTGCAAAGCTTGCGCGATGCTGCTGATCGGGCTAC
GGGCTATCAACAATAA

Upstream 100 bases:

>100_bases
TGCAACGGGCAAGTATCAACGCTTGCGCCTGCAAGAACTCTTTGCCGAATGGAATGACAGCCAGTTTCGTGAGTAGGTGG
CTGCTGTAGTTGAGGACGCT

Downstream 100 bases:

>100_bases
TTTAGATGGTTGATCTCCGCATCTTGCTTTAAATGAGCTGGGTGTGGGGATCAACCATCTATCGACCTTGATTGTGCTGT
TTTCAGCGATGGTATTTTCG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSRIAQTFERLASQGRTALMPFLTIGYPERDSALSLAQALVAGGADMLELGMPFSDPLADGATIQRTTDIALTNGVDIGF
CLETVRQLRATGMSIPLLLMGYFNPMFQYGVERFVAEAKAAGADGFIVPDLPPEEADEFHAAAKAHELDLVFLLAPTSTD
ARIAKIASLSSGFIYCVALRGVTGARAALADDLGDFLARVRQYSQLPRAVGFGISKPEHVAAVAKMAEGAICASALLDYI
GNLPAEERATGAQQFVQSLRDAADRATGYQQ

Sequences:

>Translated_271_residues
MSRIAQTFERLASQGRTALMPFLTIGYPERDSALSLAQALVAGGADMLELGMPFSDPLADGATIQRTTDIALTNGVDIGF
CLETVRQLRATGMSIPLLLMGYFNPMFQYGVERFVAEAKAAGADGFIVPDLPPEEADEFHAAAKAHELDLVFLLAPTSTD
ARIAKIASLSSGFIYCVALRGVTGARAALADDLGDFLARVRQYSQLPRAVGFGISKPEHVAAVAKMAEGAICASALLDYI
GNLPAEERATGAQQFVQSLRDAADRATGYQQ
>Mature_270_residues
SRIAQTFERLASQGRTALMPFLTIGYPERDSALSLAQALVAGGADMLELGMPFSDPLADGATIQRTTDIALTNGVDIGFC
LETVRQLRATGMSIPLLLMGYFNPMFQYGVERFVAEAKAAGADGFIVPDLPPEEADEFHAAAKAHELDLVFLLAPTSTDA
RIAKIASLSSGFIYCVALRGVTGARAALADDLGDFLARVRQYSQLPRAVGFGISKPEHVAAVAKMAEGAICASALLDYIG
NLPAEERATGAQQFVQSLRDAADRATGYQQ

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=220, Percent_Identity=37.7272727272727, Blast_Score=154, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321412, Length=264, Percent_Identity=40.530303030303, Blast_Score=228, Evalue=9e-61,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_HERA2 (A9B6M7)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544464.1
- ProteinModelPortal:   A9B6M7
- SMR:   A9B6M7
- GeneID:   5733577
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1693
- HOGENOM:   HBG391690
- OMA:   VILMTYY
- ProtClustDB:   PRK13111
- BioCyc:   HAUR316274:HAUR_1693-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28792; Mature: 28661

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIAQTFERLASQGRTALMPFLTIGYPERDSALSLAQALVAGGADMLELGMPFSDPLAD
CCHHHHHHHHHHHCCCCEEHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCC
GATIQRTTDIALTNGVDIGFCLETVRQLRATGMSIPLLLMGYFNPMFQYGVERFVAEAKA
CCEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGADGFIVPDLPPEEADEFHAAAKAHELDLVFLLAPTSTDARIAKIASLSSGFIYCVALR
CCCCCEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEC
GVTGARAALADDLGDFLARVRQYSQLPRAVGFGISKPEHVAAVAKMAEGAICASALLDYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GNLPAEERATGAQQFVQSLRDAADRATGYQQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRIAQTFERLASQGRTALMPFLTIGYPERDSALSLAQALVAGGADMLELGMPFSDPLAD
CHHHHHHHHHHHCCCCEEHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCC
GATIQRTTDIALTNGVDIGFCLETVRQLRATGMSIPLLLMGYFNPMFQYGVERFVAEAKA
CCEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGADGFIVPDLPPEEADEFHAAAKAHELDLVFLLAPTSTDARIAKIASLSSGFIYCVALR
CCCCCEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEC
GVTGARAALADDLGDFLARVRQYSQLPRAVGFGISKPEHVAAVAKMAEGAICASALLDYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GNLPAEERATGAQQFVQSLRDAADRATGYQQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA