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The map label for this gene is 159898136

Identifier: 159898136

GI number: 159898136

Start: 1872466

End: 1873470

Strand: Direct

Name: 159898136

Synonym: Haur_1612

Alternate gene names: NA

Gene position: 1872466-1873470 (Clockwise)

Preceding gene: 159898135

Following gene: 159898137

Centisome position: 29.5

GC content: 54.33

Gene sequence:

>1005_bases
ATGAAACAGCTTTCGCATGCGGCAACGGCAGTGGCTTGCGCCAACATTGCGTTTATCAAGTATTGGGGCCAGCACGACTC
GCAACTGACGCTTCCAACCAATGGCTCGATCTCCATGAATCTTGATGGCTGTCTAACCGAGACAACCGTACAATGTTTGC
CCGAAGCCGTGGACGATAGCGTGTGGCTAGCCTTAAGCGGTGGCGAAGAAGTTCAGGCCAAAGGTCGTCAATTTGAGCGG
GTGATTCAGCAGATTGAGCGGTTGCGTCAATTGGCTGGGGTCACCGAGCGGGTTGAAGTGCGTTCGCGCAATAATTTTCC
TTCTGATGCTGGCATCGCTTCGTCGGCGGCAGCGTTTGCGGCGTTGACTCGGGCGGCGGCCTCAGCTTTTCGTTTGGAGC
TTGATGAAGCCGAACTATCACGCTTGACCCGACTTTCTGGCTCAGGCTCGGCCTGCCGCTCGATTCCGGCTGGTTTTGTT
GAATGGTACAACGATGGCACGCATGCTGGCTCATATGCAGCCCAAATTGCCCCACCTGAGCACTGGAATTTGGTCGATAT
TGTGGCAGTGATTAGCACTGAGGCCAAGCATGTGGCTTCAACCAGCGGCCATAGTGTTGCCACGACCAGCCCTTATTTTT
CGGTACGCTTGGAAGGCATTGAGCAACGTTTGGCCGATGTACGCCAAGGTATTCTTGAACGTGATATTGAGCGCTTGGGG
CGAGCCTCGGAAGCTGATGCCATGTCGATGCATGTGATCGCTATGACTGCCCAACCGTCAACGATGTATTGGTTGCCTGG
TACCTTAGCGGTGATGCAAGCGGTGCAACGTTGGCGTGCCCAAGACAATCTACAAAGCTATTGGACGATTGATGCTGGCC
CGAATGTGCATGTGATTTGCGAAGCCAAGGATGCTCCCGAAGTTGAGGCACGGCTCTGCGAGTTGGATGCAGTCCAGTGG
ACGATCGTTAATGGTGCTGGCCCCGAAGCGCGTTTAGTAGGATAA

Upstream 100 bases:

>100_bases
GACAAAGCAAGGCTGTGTGGTCTGTACACCAGCCTAAATTGGCCTAGGGATCTGCTACAATACGACTACTGAATTTGTTT
ATTTGTACGTGAGGAATGGT

Downstream 100 bases:

>100_bases
GGTGCGCCGATGCTGCGACGACTACGAGCCTATTTGGTGATTGTTGGCCTGTTGGTAGCTACCGTAAGTGCTGGCTCAGC
CGAAACTGCGGCGGGACAGC

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKQLSHAATAVACANIAFIKYWGQHDSQLTLPTNGSISMNLDGCLTETTVQCLPEAVDDSVWLALSGGEEVQAKGRQFER
VIQQIERLRQLAGVTERVEVRSRNNFPSDAGIASSAAAFAALTRAAASAFRLELDEAELSRLTRLSGSGSACRSIPAGFV
EWYNDGTHAGSYAAQIAPPEHWNLVDIVAVISTEAKHVASTSGHSVATTSPYFSVRLEGIEQRLADVRQGILERDIERLG
RASEADAMSMHVIAMTAQPSTMYWLPGTLAVMQAVQRWRAQDNLQSYWTIDAGPNVHVICEAKDAPEVEARLCELDAVQW
TIVNGAGPEARLVG

Sequences:

>Translated_334_residues
MKQLSHAATAVACANIAFIKYWGQHDSQLTLPTNGSISMNLDGCLTETTVQCLPEAVDDSVWLALSGGEEVQAKGRQFER
VIQQIERLRQLAGVTERVEVRSRNNFPSDAGIASSAAAFAALTRAAASAFRLELDEAELSRLTRLSGSGSACRSIPAGFV
EWYNDGTHAGSYAAQIAPPEHWNLVDIVAVISTEAKHVASTSGHSVATTSPYFSVRLEGIEQRLADVRQGILERDIERLG
RASEADAMSMHVIAMTAQPSTMYWLPGTLAVMQAVQRWRAQDNLQSYWTIDAGPNVHVICEAKDAPEVEARLCELDAVQW
TIVNGAGPEARLVG
>Mature_334_residues
MKQLSHAATAVACANIAFIKYWGQHDSQLTLPTNGSISMNLDGCLTETTVQCLPEAVDDSVWLALSGGEEVQAKGRQFER
VIQQIERLRQLAGVTERVEVRSRNNFPSDAGIASSAAAFAALTRAAASAFRLELDEAELSRLTRLSGSGSACRSIPAGFV
EWYNDGTHAGSYAAQIAPPEHWNLVDIVAVISTEAKHVASTSGHSVATTSPYFSVRLEGIEQRLADVRQGILERDIERLG
RASEADAMSMHVIAMTAQPSTMYWLPGTLAVMQAVQRWRAQDNLQSYWTIDAGPNVHVICEAKDAPEVEARLCELDAVQW
TIVNGAGPEARLVG

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=307, Percent_Identity=35.1791530944625, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17537201, Length=320, Percent_Identity=31.25, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17537203, Length=228, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324371, Length=329, Percent_Identity=31.9148936170213, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28571205, Length=336, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 36162; Mature: 36162

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLSHAATAVACANIAFIKYWGQHDSQLTLPTNGSISMNLDGCLTETTVQCLPEAVDDS
CCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC
VWLALSGGEEVQAKGRQFERVIQQIERLRQLAGVTERVEVRSRNNFPSDAGIASSAAAFA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHH
ALTRAAASAFRLELDEAELSRLTRLSGSGSACRSIPAGFVEWYNDGTHAGSYAAQIAPPE
HHHHHHHHHHEEECCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCCCCCEEEECCCCC
HWNLVDIVAVISTEAKHVASTSGHSVATTSPYFSVRLEGIEQRLADVRQGILERDIERLG
CCCHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHC
RASEADAMSMHVIAMTAQPSTMYWLPGTLAVMQAVQRWRAQDNLQSYWTIDAGPNVHVIC
CCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEE
EAKDAPEVEARLCELDAVQWTIVNGAGPEARLVG
CCCCCCHHHHHHHHHCCEEEEEEECCCCCCEECC
>Mature Secondary Structure
MKQLSHAATAVACANIAFIKYWGQHDSQLTLPTNGSISMNLDGCLTETTVQCLPEAVDDS
CCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC
VWLALSGGEEVQAKGRQFERVIQQIERLRQLAGVTERVEVRSRNNFPSDAGIASSAAAFA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHH
ALTRAAASAFRLELDEAELSRLTRLSGSGSACRSIPAGFVEWYNDGTHAGSYAAQIAPPE
HHHHHHHHHHEEECCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCCCCCEEEECCCCC
HWNLVDIVAVISTEAKHVASTSGHSVATTSPYFSVRLEGIEQRLADVRQGILERDIERLG
CCCHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHC
RASEADAMSMHVIAMTAQPSTMYWLPGTLAVMQAVQRWRAQDNLQSYWTIDAGPNVHVIC
CCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEE
EAKDAPEVEARLCELDAVQWTIVNGAGPEARLVG
CCCCCCHHHHHHHHHCCEEEEEEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA