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The map label for this gene is rnc [H]

Identifier: 159898112

GI number: 159898112

Start: 1842793

End: 1843497

Strand: Direct

Name: rnc [H]

Synonym: Haur_1588

Alternate gene names: 159898112

Gene position: 1842793-1843497 (Clockwise)

Preceding gene: 159898111

Following gene: 159898116

Centisome position: 29.04

GC content: 50.07

Gene sequence:

>705_bases
ATGGATCTAAACAAACTACAAGCTGAACTTGGTTACACATTCAACGACTTGAATTTTTTGCGGGCGGCAATGCTGCATCG
CTCGTATGTGCACGAACACCCTGAAGCTGGCTCAGAATCGAACGAACGCCTAGAATTTTTGGGCGATGCACTTTTAAATT
TTATTTGTGGTTCTTTCTTATTTCACGAGTTTCCTGAGCTTGGTGAAGGCGATTTGACTAAAACTCGCGCGATGTTGGTG
CAAACCCGAACCTTGGCAGGTTTGGCACGCCGTTTCAATTTGGGCAGTTATGTGCAAATTAGTCGTGGCGAGGAACGTGC
CAAAGCTCGCGAACGCGACAATTTGCTGGCCGATGCCTTTGAGGCCTTGTTGGCGGCAATCGCGCTTGATGGTGGTTGGG
AAGCTGCCCGTAATTTTGTCTTGCCGTTGCTGAAGTCGGTCAAGGCCAGCGGCGTGCAAAACCAAGATTACAAGACCGAT
TTACAACAATATGTCCAAGGCCGAATCAACCTAACTCCTAGTTACCGCGAAGTTAATGTGACTGGCCCCGACCATGAACG
AACGTGGACGATTGAGGTTTGGGCGGGTGATGCACTGTTGGGAGTTGGGGTCGGAACTTCAAAAACTATGGCTTCACAGG
CGGCGGCGCGGGCAGCACTGGAAGCGCTCCAAAGCGAACAAACTACCTTACCTGAACAACGCTAA

Upstream 100 bases:

>100_bases
AACGTTAGTCTGTTGTTCAAGGCTTTTGAAGCCTAAAAAACCGCGCAAGCTAGGTAGATTCTTGGGATCTGCCTAGCTTG
CTTAGCTTAACATTGCTGCT

Downstream 100 bases:

>100_bases
TCTGAGGCTGGTGCTGGCCAGCCTCAAACTTCTGCCATTTAGCGATTAATCCGTTTGATCAATAAACCCATGCCAAAAGC
AACGCTCAAGCCACCCGCAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MDLNKLQAELGYTFNDLNFLRAAMLHRSYVHEHPEAGSESNERLEFLGDALLNFICGSFLFHEFPELGEGDLTKTRAMLV
QTRTLAGLARRFNLGSYVQISRGEERAKARERDNLLADAFEALLAAIALDGGWEAARNFVLPLLKSVKASGVQNQDYKTD
LQQYVQGRINLTPSYREVNVTGPDHERTWTIEVWAGDALLGVGVGTSKTMASQAAARAALEALQSEQTTLPEQR

Sequences:

>Translated_234_residues
MDLNKLQAELGYTFNDLNFLRAAMLHRSYVHEHPEAGSESNERLEFLGDALLNFICGSFLFHEFPELGEGDLTKTRAMLV
QTRTLAGLARRFNLGSYVQISRGEERAKARERDNLLADAFEALLAAIALDGGWEAARNFVLPLLKSVKASGVQNQDYKTD
LQQYVQGRINLTPSYREVNVTGPDHERTWTIEVWAGDALLGVGVGTSKTMASQAAARAALEALQSEQTTLPEQR
>Mature_234_residues
MDLNKLQAELGYTFNDLNFLRAAMLHRSYVHEHPEAGSESNERLEFLGDALLNFICGSFLFHEFPELGEGDLTKTRAMLV
QTRTLAGLARRFNLGSYVQISRGEERAKARERDNLLADAFEALLAAIALDGGWEAARNFVLPLLKSVKASGVQNQDYKTD
LQQYVQGRINLTPSYREVNVTGPDHERTWTIEVWAGDALLGVGVGTSKTMASQAAARAALEALQSEQTTLPEQR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=237, Percent_Identity=30.8016877637131, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI155030236, Length=237, Percent_Identity=30.8016877637131, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI29294649, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI29294651, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1788920, Length=228, Percent_Identity=39.4736842105263, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=28.755364806867, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=28.755364806867, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=31.4410480349345, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25972; Mature: 25972

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNKLQAELGYTFNDLNFLRAAMLHRSYVHEHPEAGSESNERLEFLGDALLNFICGSFL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FHEFPELGEGDLTKTRAMLVQTRTLAGLARRFNLGSYVQISRGEERAKARERDNLLADAF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
EALLAAIALDGGWEAARNFVLPLLKSVKASGVQNQDYKTDLQQYVQGRINLTPSYREVNV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEC
TGPDHERTWTIEVWAGDALLGVGVGTSKTMASQAAARAALEALQSEQTTLPEQR
CCCCCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLNKLQAELGYTFNDLNFLRAAMLHRSYVHEHPEAGSESNERLEFLGDALLNFICGSFL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FHEFPELGEGDLTKTRAMLVQTRTLAGLARRFNLGSYVQISRGEERAKARERDNLLADAF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
EALLAAIALDGGWEAARNFVLPLLKSVKASGVQNQDYKTDLQQYVQGRINLTPSYREVNV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEC
TGPDHERTWTIEVWAGDALLGVGVGTSKTMASQAAARAALEALQSEQTTLPEQR
CCCCCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA