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The map label for this gene is sphR [H]

Identifier: 159898013

GI number: 159898013

Start: 1736436

End: 1737122

Strand: Direct

Name: sphR [H]

Synonym: Haur_1488

Alternate gene names: 159898013

Gene position: 1736436-1737122 (Clockwise)

Preceding gene: 159898012

Following gene: 159898014

Centisome position: 27.36

GC content: 49.78

Gene sequence:

>687_bases
ATGGACTATACCATTTTATTAATTGATGATGAAGCTAAACTGCGCCAAGTGATTCGGCTCTCGCTTGAGCAAGAGGGCTA
TCGCGTGGTTGAGGCTAGTAATGGGCGGGAAGCGCTGTATCGGGCACGGATTGAAAAGCCCGATTTGGTGGTGCTTGACC
TGATGATGCCTGAGATGAATGGAACTGAATTTTTGCTGGCCTTTAGCAAAGAATCCAACACGCCAGTGATTATGCTCACA
GCGCGGGTCGAAGACCACGATAAAATTATTGGCTTGGAATTGGGCGCTGACGATTACATAACCAAGCCGTTTAATATGCG
TGAATTAATTGCGCGGATTCGCGCTGTGCTGCGTCGCACCCATAAACCAACGCTTGAGCCAGATCTGATTCGGGCTGGCG
ATTTGGTGCTCGATCGCGGGTCGGCAACGGTCTTGGTCGGTGAGCAACAACTAAGCCTAACTCGCTCCGAGCTTGAAATT
TTGGCCACCTTTATGACTGCGCCTGGCCTGATTTTCTCGCGGCTCGATTTGCTTGATCGCTTATCGCTTGGCGATGCCTA
CGAAGGCTATGAGCGCTCAATCGATGTGCATATTCGCAATCTGCGCACTAAAATTGAGCCAGATTCACGTCAGCCACGCT
ATATCGAGACGGTGTATGGCATGGGCTATCGCTTTAAAAAACAATGA

Upstream 100 bases:

>100_bases
CAAAATTCCCCTCCGATCCTCACAATTTCTCCATAATTGGCTGCTATGCTAGCGCTTACTGCGGCTGTTTTGGGCTGGTT
AGCGAATGGAGATTTGGCTG

Downstream 100 bases:

>100_bases
GGTGAGCTATGCGCCGAATCTGGCAGCTGCGCCACTCGTTGGCAACCAAGCTGATCTTGGCTTTTTTGTTGGTCGGCTTA
ATTGGAATTTCCTTAGTGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDYTILLIDDEAKLRQVIRLSLEQEGYRVVEASNGREALYRARIEKPDLVVLDLMMPEMNGTEFLLAFSKESNTPVIMLT
ARVEDHDKIIGLELGADDYITKPFNMRELIARIRAVLRRTHKPTLEPDLIRAGDLVLDRGSATVLVGEQQLSLTRSELEI
LATFMTAPGLIFSRLDLLDRLSLGDAYEGYERSIDVHIRNLRTKIEPDSRQPRYIETVYGMGYRFKKQ

Sequences:

>Translated_228_residues
MDYTILLIDDEAKLRQVIRLSLEQEGYRVVEASNGREALYRARIEKPDLVVLDLMMPEMNGTEFLLAFSKESNTPVIMLT
ARVEDHDKIIGLELGADDYITKPFNMRELIARIRAVLRRTHKPTLEPDLIRAGDLVLDRGSATVLVGEQQLSLTRSELEI
LATFMTAPGLIFSRLDLLDRLSLGDAYEGYERSIDVHIRNLRTKIEPDSRQPRYIETVYGMGYRFKKQ
>Mature_228_residues
MDYTILLIDDEAKLRQVIRLSLEQEGYRVVEASNGREALYRARIEKPDLVVLDLMMPEMNGTEFLLAFSKESNTPVIMLT
ARVEDHDKIIGLELGADDYITKPFNMRELIARIRAVLRRTHKPTLEPDLIRAGDLVLDRGSATVLVGEQQLSLTRSELEI
LATFMTAPGLIFSRLDLLDRLSLGDAYEGYERSIDVHIRNLRTKIEPDSRQPRYIETVYGMGYRFKKQ

Specific function: Member of the two-component regulatory system sphR/sphS. Response regulator. Involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to pho

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=42.6666666666667, Blast_Score=171, Evalue=3e-44,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=40.8695652173913, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=38.1165919282511, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.6106194690265, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=38.3259911894273, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=41.991341991342, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=36.2445414847162, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=35.8744394618834, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=33.1818181818182, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=38.6363636363636, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=33.7719298245614, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.8965517241379, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=39.622641509434, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=132, Percent_Identity=31.0606060606061, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788905, Length=166, Percent_Identity=30.7228915662651, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26172; Mature: 26172

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYTILLIDDEAKLRQVIRLSLEQEGYRVVEASNGREALYRARIEKPDLVVLDLMMPEMN
CCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCC
GTEFLLAFSKESNTPVIMLTARVEDHDKIIGLELGADDYITKPFNMRELIARIRAVLRRT
CCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
HKPTLEPDLIRAGDLVLDRGSATVLVGEQQLSLTRSELEILATFMTAPGLIFSRLDLLDR
CCCCCCCCCEECCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSLGDAYEGYERSIDVHIRNLRTKIEPDSRQPRYIETVYGMGYRFKKQ
HCCCCCCCCHHCEEEEEEEEEEECCCCCCCCCCEEEHHHCCCEEEECC
>Mature Secondary Structure
MDYTILLIDDEAKLRQVIRLSLEQEGYRVVEASNGREALYRARIEKPDLVVLDLMMPEMN
CCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCC
GTEFLLAFSKESNTPVIMLTARVEDHDKIIGLELGADDYITKPFNMRELIARIRAVLRRT
CCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
HKPTLEPDLIRAGDLVLDRGSATVLVGEQQLSLTRSELEILATFMTAPGLIFSRLDLLDR
CCCCCCCCCEECCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSLGDAYEGYERSIDVHIRNLRTKIEPDSRQPRYIETVYGMGYRFKKQ
HCCCCCCCCHHCEEEEEEEEEEECCCCCCCCCCEEEHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8497200; 8157591 [H]