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The map label for this gene is vraR [H]

Identifier: 159897838

GI number: 159897838

Start: 1519839

End: 1520459

Strand: Direct

Name: vraR [H]

Synonym: Haur_1309

Alternate gene names: 159897838

Gene position: 1519839-1520459 (Clockwise)

Preceding gene: 159897837

Following gene: 159897839

Centisome position: 23.95

GC content: 50.72

Gene sequence:

>621_bases
ATGATCCGCATTTTGGTGGTTGATGATCATCCGGTGGTGCGCGAGGGCTTGGTGGCAATTCTCAGCACCCAAGCCGATTT
TTCCGTGGTTGGTGAGGCTAGCGCTGGGCTGCAAGCTGTCGAATTGTGTCAGCAATTGCAACCTGATCTGGTATTGCTCG
ACCTTGAGTTGCCTGATCTCGATGGAGTGGCGGTGCTTGAGCGGCTTGATTTGGCGGCGACCAACCGACGCGTGTTGGTA
TTTACCGCGTTTGATACCGATGAACGGATTATTGGCGCGGTGCGGGCTGGTGCTCAGGGCTATTTGCTCAAAGGCGCTCC
GCGTGATGAATTATTTGCAGCAATTCGCTTGATTCATGCTGGTGGCTCGACCTTGCACCCCTTGATTGCCTCGAAATTGT
TGCGCCAAGTGCAGCGCGATACAACCTTGGTTGAATTAACGCCGCGTGAGCATGAAGTATTGCAACATTTAGCCCAAGGC
TTTGCTAATAAGCAAATTGCCTACCAACTTAATATTACCGAGCGCACAGTTAAATTCCATCTGAATAGTATTTTTCAAAA
GCTTGGGGCGCACAATCGCACCGAGGCTGTGGCGATTGCCTATGAACGCCAATTAATTTAG

Upstream 100 bases:

>100_bases
TGAATGAGCGTACTCGGTTGCTGAGCGGCAGCCTTGAAATCAAAAGTACCCTTGGCGCAGGGACTGAGGTTTGTATTGTT
GTGCCACTGGGGAGTTCCAA

Downstream 100 bases:

>100_bases
TAGGTTAATTCGATGACTCCAACTCGTTATCAAATTCCGGCAGCTGAGCATGAATTTGAACAAGATATCAAACATTCACG
CTTTATTGCGACGGTTGTGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIRILVVDDHPVVREGLVAILSTQADFSVVGEASAGLQAVELCQQLQPDLVLLDLELPDLDGVAVLERLDLAATNRRVLV
FTAFDTDERIIGAVRAGAQGYLLKGAPRDELFAAIRLIHAGGSTLHPLIASKLLRQVQRDTTLVELTPREHEVLQHLAQG
FANKQIAYQLNITERTVKFHLNSIFQKLGAHNRTEAVAIAYERQLI

Sequences:

>Translated_206_residues
MIRILVVDDHPVVREGLVAILSTQADFSVVGEASAGLQAVELCQQLQPDLVLLDLELPDLDGVAVLERLDLAATNRRVLV
FTAFDTDERIIGAVRAGAQGYLLKGAPRDELFAAIRLIHAGGSTLHPLIASKLLRQVQRDTTLVELTPREHEVLQHLAQG
FANKQIAYQLNITERTVKFHLNSIFQKLGAHNRTEAVAIAYERQLI
>Mature_206_residues
MIRILVVDDHPVVREGLVAILSTQADFSVVGEASAGLQAVELCQQLQPDLVLLDLELPDLDGVAVLERLDLAATNRRVLV
FTAFDTDERIIGAVRAGAQGYLLKGAPRDELFAAIRLIHAGGSTLHPLIASKLLRQVQRDTTLVELTPREHEVLQHLAQG
FANKQIAYQLNITERTVKFHLNSIFQKLGAHNRTEAVAIAYERQLI

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=38.2775119617225, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=35.3535353535354, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788222, Length=204, Percent_Identity=31.3725490196078, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=25.3588516746411, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87082052, Length=111, Percent_Identity=39.6396396396396, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788712, Length=187, Percent_Identity=25.1336898395722, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=27.6381909547739, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788550, Length=193, Percent_Identity=28.4974093264249, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22724; Mature: 22724

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRILVVDDHPVVREGLVAILSTQADFSVVGEASAGLQAVELCQQLQPDLVLLDLELPDL
CEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCC
DGVAVLERLDLAATNRRVLVFTAFDTDERIIGAVRAGAQGYLLKGAPRDELFAAIRLIHA
CHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHC
GGSTLHPLIASKLLRQVQRDTTLVELTPREHEVLQHLAQGFANKQIAYQLNITERTVKFH
CCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHH
LNSIFQKLGAHNRTEAVAIAYERQLI
HHHHHHHHCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MIRILVVDDHPVVREGLVAILSTQADFSVVGEASAGLQAVELCQQLQPDLVLLDLELPDL
CEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCC
DGVAVLERLDLAATNRRVLVFTAFDTDERIIGAVRAGAQGYLLKGAPRDELFAAIRLIHA
CHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHC
GGSTLHPLIASKLLRQVQRDTTLVELTPREHEVLQHLAQGFANKQIAYQLNITERTVKFH
CCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHH
LNSIFQKLGAHNRTEAVAIAYERQLI
HHHHHHHHCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]