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The map label for this gene is fkpA [H]

Identifier: 159896789

GI number: 159896789

Start: 300413

End: 300913

Strand: Direct

Name: fkpA [H]

Synonym: Haur_0256

Alternate gene names: 159896789

Gene position: 300413-300913 (Clockwise)

Preceding gene: 159896781

Following gene: 159896794

Centisome position: 4.73

GC content: 51.1

Gene sequence:

>501_bases
GTGAAGCGTATTCTTCTTTCAATGTTGGTTGCGGTAACATTAATTGGCTGTGGCGAGATTGCTCGCCCCGAAAACCCGAC
TGCTGTTCCAACCTCAGCCACCACTGGCGTAGATATTTCAGATGTTTCGGCAGTTATTCCAGCGCTGCCCAATGGTTTAG
AAGTGAAGCAAACTGCCAGCGGCTTGCGCTATGTGGATATTGTGGTGGGGAGTGGCCCTGAGGTGACGGCTGGCTCAACC
GCTGAGGTTTTTTACACTGGCTACCTTAAATCCGATGGCTCACAATTCGATTCAAATGTTGGTGGTCAGCCATATGCGGT
CGAAGGTGTTGGCGGAGCCATGGTTATCACTGGCTGGAATGAAGGTTTGGTTGGCATCAAGCAAGGTGGCAAGCGCCGCT
TGATTATTCCTTCGGCCTTGGCTTATGGCGAGCAAGGTCAGGGGACGATTCCAGCTAACGCCGATTTGGTGTTTGATGTT
GAAGTTATGACGGTTCGGTAA

Upstream 100 bases:

>100_bases
GAAGATTGCCAACACATTGAGAATGATGTAAAGCTGATGAATCTGTGAAGCAAGGTATAATAGCGGCGTTTGGTTTCAAT
TTGTGATGAAAGGGCGTTCC

Downstream 100 bases:

>100_bases
AGAACATAGAACATAGATTAATGGTTCATCAGATTGACAATCTATTGTTCCCTCACCCCCTAGCCCCCTCGCCCGCCCAG
CAGGCGAGGGGGAATCGCTT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKRILLSMLVAVTLIGCGEIARPENPTAVPTSATTGVDISDVSAVIPALPNGLEVKQTASGLRYVDIVVGSGPEVTAGST
AEVFYTGYLKSDGSQFDSNVGGQPYAVEGVGGAMVITGWNEGLVGIKQGGKRRLIIPSALAYGEQGQGTIPANADLVFDV
EVMTVR

Sequences:

>Translated_166_residues
MKRILLSMLVAVTLIGCGEIARPENPTAVPTSATTGVDISDVSAVIPALPNGLEVKQTASGLRYVDIVVGSGPEVTAGST
AEVFYTGYLKSDGSQFDSNVGGQPYAVEGVGGAMVITGWNEGLVGIKQGGKRRLIIPSALAYGEQGQGTIPANADLVFDV
EVMTVR
>Mature_166_residues
MKRILLSMLVAVTLIGCGEIARPENPTAVPTSATTGVDISDVSAVIPALPNGLEVKQTASGLRYVDIVVGSGPEVTAGST
AEVFYTGYLKSDGSQFDSNVGGQPYAVEGVGGAMVITGWNEGLVGIKQGGKRRLIIPSALAYGEQGQGTIPANADLVFDV
EVMTVR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=90, Percent_Identity=45.5555555555556, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI17149844, Length=90, Percent_Identity=45.5555555555556, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI17149842, Length=90, Percent_Identity=45.5555555555556, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=41.304347826087, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI150010552, Length=106, Percent_Identity=40.5660377358491, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=41.3793103448276, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=113, Percent_Identity=44.2477876106195, Blast_Score=64, Evalue=4e-12,
Organism=Escherichia coli, GI87082390, Length=115, Percent_Identity=41.7391304347826, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=101, Percent_Identity=41.5841584158416, Blast_Score=85, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=101, Percent_Identity=40.5940594059406, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=50.5494505494505, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=42.3913043478261, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647110, Length=107, Percent_Identity=42.0560747663551, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363946, Length=106, Percent_Identity=41.5094339622642, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17352457, Length=106, Percent_Identity=41.5094339622642, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17083; Mature: 17083

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILLSMLVAVTLIGCGEIARPENPTAVPTSATTGVDISDVSAVIPALPNGLEVKQTAS
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEHHHCC
GLRYVDIVVGSGPEVTAGSTAEVFYTGYLKSDGSQFDSNVGGQPYAVEGVGGAMVITGWN
CCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECC
EGLVGIKQGGKRRLIIPSALAYGEQGQGTIPANADLVFDVEVMTVR
CCEEEECCCCCEEEEECHHHHCCCCCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MKRILLSMLVAVTLIGCGEIARPENPTAVPTSATTGVDISDVSAVIPALPNGLEVKQTAS
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEHHHCC
GLRYVDIVVGSGPEVTAGSTAEVFYTGYLKSDGSQFDSNVGGQPYAVEGVGGAMVITGWN
CCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECC
EGLVGIKQGGKRRLIIPSALAYGEQGQGTIPANADLVFDVEVMTVR
CCEEEECCCCCEEEEECHHHHCCCCCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]