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The map label for this gene is ubiE [H]

Identifier: 159896643

GI number: 159896643

Start: 143562

End: 144386

Strand: Reverse

Name: ubiE [H]

Synonym: Haur_0110

Alternate gene names: 159896643

Gene position: 144386-143562 (Counterclockwise)

Preceding gene: 159896644

Following gene: 159896642

Centisome position: 2.28

GC content: 50.79

Gene sequence:

>825_bases
ATGAACGATCAATCGATTAAAGCCAGCGTCCAAGCCTATTATGGTGAATGGGCTGAGCAAGTGCAGCAGGAGCAGCCAAA
AACTAGTTGTTGCAGCAGCCATGATATTTCGCTAAGCAGCACGCTCTACCGTGATACAACAACCGCCGATTTGCCCGCAA
CCGCCGTCAACAGCACCCGTGGTTGTGGCAATCCAGTTGTGCGGGCCGCCTTGCAACTAGGCCAGGTCGTGCTTGATCTT
GGCTCTGGTGGCGGTTTGGATGTGTTGCTTGCTGCCAAACAAGTTGGACCAAGCGGCTTTGTCTATGGAGTTGATATGAC
CGATGCCATGCTCGATTTGGCCCGCCAGAATGCGCATAAAGCCCAGATTGAGAATGTGGCTTTTTTGAAAGGCGATATTG
AGCAACTGCCACTTGAGAATGAGCAAGTCGATGTAATTATCTCCAATTGCGTGATTAACCTCGCTCCCGATAAGGGCATG
GCCTTGCGCGAGGCCTATCGTGTGCTCAAAGTTGGCGGCTATATGGCGATCTCCGATATTGTGATCGACGGCAGTTTGGC
TGATTTTCCTTTGCCTGAAGCCAGTTTACGCGCGGCCATGAACTGGGCTGGTTGTGTAGCGGGTGCGCCAACGCGTGAAC
AATATCAACAATTTTTGGCGCAAGCAGGCTTTCAAGCGATTAGTTTCGAGGTAACCCATCGCTATAGCTTCGAGGATATT
GGCGGCAAGTTGCCCGAGGAATTAGCCGGATTAAGCGATTTGCAAGGCCAACAATTGGCTGAACGCTTTACATCGTGCTT
GATTCGTGCCCATAAACAAATTTGA

Upstream 100 bases:

>100_bases
GCAGTGGGGCAGCATTTGCAGCAGCGCGACCTTGATGGTCAAACACTTAGTTTAATTTTTTTGCTAGCAAGATTGAATTT
TTTCAATGGAGAAGTGAATC

Downstream 100 bases:

>100_bases
GTTTCACTTAAAATTGCCTATAATAAGCCAAAACTCGTACCATTTAAGATCAATCCATTAGATGTTTCAATGCATTGAAA
CATCTAATGGATTTTTATGC

Product: type 11 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNDQSIKASVQAYYGEWAEQVQQEQPKTSCCSSHDISLSSTLYRDTTTADLPATAVNSTRGCGNPVVRAALQLGQVVLDL
GSGGGLDVLLAAKQVGPSGFVYGVDMTDAMLDLARQNAHKAQIENVAFLKGDIEQLPLENEQVDVIISNCVINLAPDKGM
ALREAYRVLKVGGYMAISDIVIDGSLADFPLPEASLRAAMNWAGCVAGAPTREQYQQFLAQAGFQAISFEVTHRYSFEDI
GGKLPEELAGLSDLQGQQLAERFTSCLIRAHKQI

Sequences:

>Translated_274_residues
MNDQSIKASVQAYYGEWAEQVQQEQPKTSCCSSHDISLSSTLYRDTTTADLPATAVNSTRGCGNPVVRAALQLGQVVLDL
GSGGGLDVLLAAKQVGPSGFVYGVDMTDAMLDLARQNAHKAQIENVAFLKGDIEQLPLENEQVDVIISNCVINLAPDKGM
ALREAYRVLKVGGYMAISDIVIDGSLADFPLPEASLRAAMNWAGCVAGAPTREQYQQFLAQAGFQAISFEVTHRYSFEDI
GGKLPEELAGLSDLQGQQLAERFTSCLIRAHKQI
>Mature_274_residues
MNDQSIKASVQAYYGEWAEQVQQEQPKTSCCSSHDISLSSTLYRDTTTADLPATAVNSTRGCGNPVVRAALQLGQVVLDL
GSGGGLDVLLAAKQVGPSGFVYGVDMTDAMLDLARQNAHKAQIENVAFLKGDIEQLPLENEQVDVIISNCVINLAPDKGM
ALREAYRVLKVGGYMAISDIVIDGSLADFPLPEASLRAAMNWAGCVAGAPTREQYQQFLAQAGFQAISFEVTHRYSFEDI
GGKLPEELAGLSDLQGQQLAERFTSCLIRAHKQI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=242, Percent_Identity=30.5785123966942, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29499; Mature: 29499

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQSIKASVQAYYGEWAEQVQQEQPKTSCCSSHDISLSSTLYRDTTTADLPATAVNSTR
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHCCCC
GCGNPVVRAALQLGQVVLDLGSGGGLDVLLAAKQVGPSGFVYGVDMTDAMLDLARQNAHK
CCCCHHHHHHHHHHHHHEECCCCCCEEEEEEHHHCCCCCEEEECCHHHHHHHHHHHHHHH
AQIENVAFLKGDIEQLPLENEQVDVIISNCVINLAPDKGMALREAYRVLKVGGYMAISDI
HHHHHHHHCCCCHHHCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEHE
VIDGSLADFPLPEASLRAAMNWAGCVAGAPTREQYQQFLAQAGFQAISFEVTHRYSFEDI
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHH
GGKLPEELAGLSDLQGQQLAERFTSCLIRAHKQI
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDQSIKASVQAYYGEWAEQVQQEQPKTSCCSSHDISLSSTLYRDTTTADLPATAVNSTR
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHCCCC
GCGNPVVRAALQLGQVVLDLGSGGGLDVLLAAKQVGPSGFVYGVDMTDAMLDLARQNAHK
CCCCHHHHHHHHHHHHHEECCCCCCEEEEEEHHHCCCCCEEEECCHHHHHHHHHHHHHHH
AQIENVAFLKGDIEQLPLENEQVDVIISNCVINLAPDKGMALREAYRVLKVGGYMAISDI
HHHHHHHHCCCCHHHCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEHE
VIDGSLADFPLPEASLRAAMNWAGCVAGAPTREQYQQFLAQAGFQAISFEVTHRYSFEDI
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHH
GGKLPEELAGLSDLQGQQLAERFTSCLIRAHKQI
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]