Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 159896558

GI number: 159896558

Start: 32386

End: 33102

Strand: Direct

Name: trxA [H]

Synonym: Haur_0025

Alternate gene names: 159896558

Gene position: 32386-33102 (Clockwise)

Preceding gene: 159896557

Following gene: 159896559

Centisome position: 0.51

GC content: 51.46

Gene sequence:

>717_bases
ATGACATTCTCAACCCCAATTCATACCAACGATCAAAGTTTCGAGCGCGTGCTCAATACTGGGTATCCCTTGATGGTCGT
GTGGAGCAGCAAAACCGATCCTCAGAGCCAAGCCTTCGATAAAGTGCTGAATCTTTTGGCGATTCAATTTGAAGGTCGGG
CCTTGATCGTCAAAGTCAATCCTGAAGAAAACCCGAAGCTTACCAAGGATTATGCAATTAGCGCAATTCCAAGTGCTGTC
TTTATTCGCCAAGGCGAGGTACAAGGCCGTTGTGTTGGCGGATTGAGCAAAGAGCAATTGCAGCCTGTACTTGAGGCCTT
AGTCAATGGCCAAGCCTTGGGTAATCTGCCGAATGCGGCTAGCACACCGCTAACACCAGCAGCAGCGGTTGCAGGCGGCT
CAACCCCATTGACGCTGACTGATGCCAATTTTGAGCAAACCATTCGTAGCGGCCAAACTGTACTGGTCGATTTTTGGGCG
GCTTGGTGTGGGCCGTGTCGGGCGATTGCGCCTTCGATCGAAAGCTTAGCCAAAGAATTTGCTGGGCGAGCAGTCGTAGC
CAAATTGAATGTTGATGAAAACCCACGCATCGCCCAACGCTTCAATATCCAAGGCATTCCAGCCTTGTTGGTGTTCAAGG
GTGGCAAAGTGGTCGAACAAGTCACTGGAGCACAGCCCTTGCCTGCATTGCGCCAAGTCCTAGCCCGTCACGCCTAA

Upstream 100 bases:

>100_bases
AATTTAATTCAATAAAAAAGAATAAACATTGACAGATTGCTAATGCAACGAGCTGTGGCAGCGTGTTACACTCAAACCAG
TAACACCAAGGAGGTCAGCG

Downstream 100 bases:

>100_bases
ATTTGGCTATTGCTAGGCCATGAAGGCATGCGGTAAAATAAAGCCACGTTGCAGCACAAGCATTTGTGGTGCAAGCCGCA
TCCTCGCAATCGCCCTAGCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTFSTPIHTNDQSFERVLNTGYPLMVVWSSKTDPQSQAFDKVLNLLAIQFEGRALIVKVNPEENPKLTKDYAISAIPSAV
FIRQGEVQGRCVGGLSKEQLQPVLEALVNGQALGNLPNAASTPLTPAAAVAGGSTPLTLTDANFEQTIRSGQTVLVDFWA
AWCGPCRAIAPSIESLAKEFAGRAVVAKLNVDENPRIAQRFNIQGIPALLVFKGGKVVEQVTGAQPLPALRQVLARHA

Sequences:

>Translated_238_residues
MTFSTPIHTNDQSFERVLNTGYPLMVVWSSKTDPQSQAFDKVLNLLAIQFEGRALIVKVNPEENPKLTKDYAISAIPSAV
FIRQGEVQGRCVGGLSKEQLQPVLEALVNGQALGNLPNAASTPLTPAAAVAGGSTPLTLTDANFEQTIRSGQTVLVDFWA
AWCGPCRAIAPSIESLAKEFAGRAVVAKLNVDENPRIAQRFNIQGIPALLVFKGGKVVEQVTGAQPLPALRQVLARHA
>Mature_237_residues
TFSTPIHTNDQSFERVLNTGYPLMVVWSSKTDPQSQAFDKVLNLLAIQFEGRALIVKVNPEENPKLTKDYAISAIPSAVF
IRQGEVQGRCVGGLSKEQLQPVLEALVNGQALGNLPNAASTPLTPAAAVAGGSTPLTLTDANFEQTIRSGQTVLVDFWAA
WCGPCRAIAPSIESLAKEFAGRAVVAKLNVDENPRIAQRFNIQGIPALLVFKGGKVVEQVTGAQPLPALRQVLARHA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI224493972, Length=198, Percent_Identity=28.2828282828283, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI42794771, Length=198, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI5803121, Length=220, Percent_Identity=27.7272727272727, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=36.144578313253, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21361403, Length=120, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI21361657, Length=108, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=44.4444444444444, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788936, Length=90, Percent_Identity=36.6666666666667, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=31.3725490196078, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=92, Percent_Identity=40.2173913043478, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980565, Length=104, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=98, Percent_Identity=33.6734693877551, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=109, Percent_Identity=31.1926605504587, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=87, Percent_Identity=36.7816091954023, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=102, Percent_Identity=34.3137254901961, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=34, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=92, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=42.4242424242424, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=41.2371134020619, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=30.5882352941176, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639826, Length=98, Percent_Identity=36.734693877551, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=39.7959183673469, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584105, Length=164, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=38.6666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=35.5555555555556, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 25480; Mature: 25348

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSTPIHTNDQSFERVLNTGYPLMVVWSSKTDPQSQAFDKVLNLLAIQFEGRALIVKVN
CCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEECCCEEEEEEC
PEENPKLTKDYAISAIPSAVFIRQGEVQGRCVGGLSKEQLQPVLEALVNGQALGNLPNAA
CCCCCCCCHHHHHHHCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCHHHCCCCCCC
STPLTPAAAVAGGSTPLTLTDANFEQTIRSGQTVLVDFWAAWCGPCRAIAPSIESLAKEF
CCCCCCHHHHCCCCCCEEEECCCHHHHHHCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHH
AGRAVVAKLNVDENPRIAQRFNIQGIPALLVFKGGKVVEQVTGAQPLPALRQVLARHA
CCCEEEEEECCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TFSTPIHTNDQSFERVLNTGYPLMVVWSSKTDPQSQAFDKVLNLLAIQFEGRALIVKVN
CCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEECCCEEEEEEC
PEENPKLTKDYAISAIPSAVFIRQGEVQGRCVGGLSKEQLQPVLEALVNGQALGNLPNAA
CCCCCCCCHHHHHHHCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCHHHCCCCCCC
STPLTPAAAVAGGSTPLTLTDANFEQTIRSGQTVLVDFWAAWCGPCRAIAPSIESLAKEF
CCCCCCHHHHCCCCCCEEEECCCHHHHHHCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHH
AGRAVVAKLNVDENPRIAQRFNIQGIPALLVFKGGKVVEQVTGAQPLPALRQVLARHA
CCCEEEEEECCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9359865; 10632710 [H]