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The map label for this gene is dnaA

Identifier: 159896534

GI number: 159896534

Start: 77

End: 1495

Strand: Direct

Name: dnaA

Synonym: Haur_0001

Alternate gene names: 159896534

Gene position: 77-1495 (Clockwise)

Preceding gene: NA

Following gene: 159896538

Centisome position: 0.0

GC content: 50.67

Gene sequence:

>1419_bases
TTGGATACAAAACAGATTTGGTTTACTACGCTCGGAACATTGCAAAACCAAATACTTCGCTATGATTACGATACATGGCT
TAAAACCACAGCATTGGTCTCGGTAGCCAACGATTTGGCGGTGATTGGTGCGCCCAATGTCACCACCAAACAAGTGATCG
AAGATCGTTTTATGAGTGTGTTGCGCCGTGCTTTAGGCGAGGTTTTGGGCTATCAAGTTAATGTACGAGTGATTATCAGT
AGCGCTACGCCAGCTCCAAGCGAGCCAGTTGCCGTAACTCCAAGCGAGCCAAGCCCAACAACTGAGGTGGCCGAGCCAAG
TTTTGCCAGTTTCAATCAGGCTGCGCCAATGCTCAACCAACTGCCGTTGGGCGATCCCAATCGCTCGTCAGTGCTCAACC
CACGCTATACGTTTTCCTCGTTCATCGTTGGGACATCCAATCGTTTGGCCCATGCTGCCTGTATGGCAGTAGCCGAACAC
CCTGCCCAAGCCTATAATCCGCTCTTTTTATATGGTGGAGTGGGGCTGGGCAAAACCCACTTGTTGCAGGCGATTGGCAA
CTATGCGCTTGATCGAAATCCTGAAGTGAATGTGCTCTATGTGTCGTCGGAGAAATTCACCAACGATTTGATCAACGCCA
TCCGTCGCCAACAAACCGAAGAATTTCGCATTCGCTACCGCAATATTGATATTTTGCTGATCGACGATATTCAGTTTATC
GCGGGCAAAGAAGGTACGCAGGAAGAATTTTTCCATACCTTCAATACCTTGCATGGCGCGGGCAAACAAATTGTGCTCAG
CTCAGATCGCCCGCCAAAAGCGATTTTGACCCTTGAGGAGCGTTTACGTTCACGCTTTGAATGGGGCTTGATTGTCGATG
TGCAAAACCCAGATCTCGAAACCCGCACGGCGATTTTGCGAGCCAAAGGCGAGACCTTACAAGTGCCTGTTTCCTCAGAG
GTGATCGACTTCTTGGCTCAACGAATTCAAAGCAATATTCGCGAACTTGAGGGCTGTTTGAATCGGGTGATCGCTTATGC
TAATCTCAATCGCACGCCAGTTACGGTTGAAGTTGCTTCGGCAGCCTTGGCCGATTTGCTCGATACCAGTCGGCGCAAAC
GGGTAACGGCTGATGATATTTTTCGCGAAGTTTCACAACATTATGGCATCGATCAACGGGCAATTCGGGGGCGAGGCCGT
TCGCGCAATGTGGTGTTGCCGCGCCAAGTGGTGATGTATTTGCTGCGCGAAGAGACCGATGCCTCGCTGGTTGAAATTGG
CGAGTTGCTTGGTGGCCGCGACCATACCACCGTCATGCATGGTTACAACAAAATTACCGATGACCTCACCAGCGATGCCC
GTTTGCGCAACGATATTACCTCGCTGCGCCAACGGCTCTACGGCGAAAACGCCCGTTGA

Upstream 100 bases:

>100_bases
GCAAGCTACATTTTGCCTACATCGATACAACGACTCTCCTGTGGGCTGATGAACTCAACGGCGAGTTGGACGACCCACCA
GCACAGAGGAGCTTTTGGCT

Downstream 100 bases:

>100_bases
GCTTATAACGGCCTCGCTTTACAACTATGGGCTAGGCCGTTATTGTGATTAATGTTCCAAATACCAAGGAACATTAATCA
CAATAATTTGGGCATTACCG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSVLRRALGEVLGYQVNVRVIIS
SATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQLPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEH
PAQAYNPLFLYGGVGLGKTHLLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFI
AGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLETRTAILRAKGETLQVPVSSE
VIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVASAALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGR
SRNVVLPRQVVMYLLREETDASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR

Sequences:

>Translated_472_residues
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSVLRRALGEVLGYQVNVRVIIS
SATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQLPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEH
PAQAYNPLFLYGGVGLGKTHLLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFI
AGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLETRTAILRAKGETLQVPVSSE
VIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVASAALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGR
SRNVVLPRQVVMYLLREETDASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR
>Mature_472_residues
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSVLRRALGEVLGYQVNVRVIIS
SATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQLPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEH
PAQAYNPLFLYGGVGLGKTHLLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFI
AGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLETRTAILRAKGETLQVPVSSE
VIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVASAALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGR
SRNVVLPRQVVMYLLREETDASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=460, Percent_Identity=40.6521739130435, Blast_Score=337, Evalue=8e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_HERA2 (A9B496)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001542781.1
- ProteinModelPortal:   A9B496
- SMR:   A9B496
- GeneID:   5736835
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0001
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   HAUR316274:HAUR_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52822; Mature: 52822

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSV
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
LRRALGEVLGYQVNVRVIISSATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQ
HHHHHHHHHCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
LPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEHPAQAYNPLFLYGGVGLGKTH
CCCCCCCCCCCCCCCHHHHHEEECCCCHHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHH
LLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFI
HHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHEEEECEEEEEECCCHHH
AGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLE
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCH
TRTAILRAKGETLQVPVSSEVIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVAS
HHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
AALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGRSRNVVLPRQVVMYLLREETD
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEECHHHHHHHHHHCCCC
ASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR
HHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSV
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
LRRALGEVLGYQVNVRVIISSATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQ
HHHHHHHHHCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
LPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEHPAQAYNPLFLYGGVGLGKTH
CCCCCCCCCCCCCCCHHHHHEEECCCCHHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHH
LLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFI
HHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHEEEECEEEEEECCCHHH
AGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLE
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCH
TRTAILRAKGETLQVPVSSEVIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVAS
HHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
AALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGRSRNVVLPRQVVMYLLREETD
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEECHHHHHHHHHHCCCC
ASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR
HHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA