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The map label for this gene is pcp

Identifier: 15928276

GI number: 15928276

Start: 2793791

End: 2794429

Strand: Direct

Name: pcp

Synonym: SA2482

Alternate gene names: 15928276

Gene position: 2793791-2794429 (Clockwise)

Preceding gene: 15928275

Following gene: 15928279

Centisome position: 99.25

GC content: 37.25

Gene sequence:

>639_bases
ATGCACATTTTAGTAACAGGGTTTGCGCCTTTTGACAATCAAAATATCAATCCCTCATGGGAAGCTGTGACTCAACTAGA
AGATATTATTGGCACACATACAATCGATAAATTAAAACTACCAACCTCTTTTAAGAAAGTAGATAATATTATAAATAAAA
CGTTGGCATCTAATCATTATGATGTTGTACTAGCTATAGGACAAGCTGGTGGTAGAAATGCCATTACCCCAGAACGTGTC
GCCATTAATATTGATGATGCACGTATTCCAGATAATGATGATTTTCAACCTATTGATCAAGCCATTCACTTAGACGGTGC
GCCAGCTTATTTTTCAAATTTACCAGTTAAAGCAATGACTCAAAGTATTATTAATCAAGGACTTCCTGGAGCACTTTCAA
ATAGCGCAGGTACGTATGTATGTAATCACGTGCTTTATCACTTAGGTTATTTACAAGATAAGCATTACCCTCACCTACGA
TTCGGATTTATTCATGTGCCATACATACCAGAGCAGGTCATTGGTAAACCCGATACACCATCTATGCCATTAGAAAAGAT
AGTTGCAGGTTTGACTGCAGCCATTGAAGCTATTTCTAATGATGAGGATTTACGTATAGCTCTAGGCACAACGGAATAG

Upstream 100 bases:

>100_bases
TTTTTCAAGGCTGTTTTTTATGCGCATACATAACCTGATATGTTTTTAATTATGCGCGTGTTATACTAAATTAAATTTTA
ATACTGCGGGGTGTCTTAAA

Downstream 100 bases:

>100_bases
TTATAAATGCACAAACAAAAGCACCCTAATTTGTTAGTTTAAGTCTAACTTTAGGGTGCTTTTGGATGATTGGTATACAG
TTTTACTATAATGATGTATT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHYDVVLAIGQAGGRNAITPERV
AINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMTQSIINQGLPGALSNSAGTYVCNHVLYHLGYLQDKHYPHLR
FGFIHVPYIPEQVIGKPDTPSMPLEKIVAGLTAAIEAISNDEDLRIALGTTE

Sequences:

>Translated_212_residues
MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHYDVVLAIGQAGGRNAITPERV
AINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMTQSIINQGLPGALSNSAGTYVCNHVLYHLGYLQDKHYPHLR
FGFIHVPYIPEQVIGKPDTPSMPLEKIVAGLTAAIEAISNDEDLRIALGTTE
>Mature_212_residues
MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHYDVVLAIGQAGGRNAITPERV
AINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMTQSIINQGLPGALSNSAGTYVCNHVLYHLGYLQDKHYPHLR
FGFIHVPYIPEQVIGKPDTPSMPLEKIVAGLTAAIEAISNDEDLRIALGTTE

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=179, Percent_Identity=27.3743016759777, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_STAA1 (A7X782)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001443264.1
- ProteinModelPortal:   A7X782
- SMR:   A7X782
- STRING:   A7X782
- EnsemblBacteria:   EBSTAT00000003254
- GeneID:   5561033
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2674
- eggNOG:   COG2039
- GeneTree:   EBGT00050000024306
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   SAUR418127:SAHV_2674-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23201; Mature: 23201

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHY
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHHHCCCCC
DVVLAIGQAGGRNAITPERVAINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMT
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHEECCCCCHHHHCCCHHHHH
QSIINQGLPGALSNSAGTYVCNHVLYHLGYLQDKHYPHLRFGFIHVPYIPEQVIGKPDTP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHCCCCCCC
SMPLEKIVAGLTAAIEAISNDEDLRIALGTTE
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHY
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHHHCCCCC
DVVLAIGQAGGRNAITPERVAINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMT
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHEECCCCCHHHHCCCHHHHH
QSIINQGLPGALSNSAGTYVCNHVLYHLGYLQDKHYPHLRFGFIHVPYIPEQVIGKPDTP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHCCCCCCC
SMPLEKIVAGLTAAIEAISNDEDLRIALGTTE
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA