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The map label for this gene is pyrD [H]

Identifier: 15928168

GI number: 15928168

Start: 2664073

End: 2665137

Strand: Direct

Name: pyrD [H]

Synonym: SA2375

Alternate gene names: 15928168

Gene position: 2664073-2665137 (Clockwise)

Preceding gene: 15928160

Following gene: 15928169

Centisome position: 94.64

GC content: 35.68

Gene sequence:

>1065_bases
ATGTACAAATTAATTAAACCTTTCTTATTCAAAATCGAACCCGAAAAAGCACACGGACTAACTATCGATGCATTAAAAAC
GTTACAAAAGTTTCCGGTTTTATTCCCAGTCGTCGATAAACTATTTACTTATAAGAATCCAACGTTATCACAAACGATAC
AAGGTAATACGTACGACAATCCAATTGGCTTAGCAGCTGGTTTCGACAAATCTTGCGAAGTACCAAAAGCATTGGAACAC
CTTGGATTCGGTGCTTTAGAATTAGGTGGTATCACACCTAAACCTCAACCGGGTAACCCTCAACCACGCATGTTTAGATT
ATTAGAAGATGACGCCTTGATAAATCGAATGGGCTTCAATAATATTGGTATGAACAAAGCACTCAGTCATTTGCGTAAAA
ATGCTTATCAAGTACCTGTTGGTATCAATGTTGGTGTGAATAAAATGACACCTTATGAAGCGCGTTATCAAGATTATATA
AAAGTCATTGATACGTTTAAACACGACGTTTCATTTTTCACAGTCAATATCAGTTCTCCAAATACTGAAAACCTTCAAAA
TTTCCATGATAAAGATGAATTTTCAATGTTATGTCAAGCTTTGACAACATTTAAAAAACAGCACGATGTAACAGTGCCAA
TTTACTTAAAACTAACGTCTGATATGGATTTCGATGGCTTAAAAGCACTATTACCAGCGATTACTGAGACATTTGACGGT
ATCATCTTAGCAAACACAACGCGACAACGAGATGGTTTAACTTCTGCTAATAAAGTCGAAGAAGGCGGTTTGAGTGGTCG
TCCATTATTTGAACGTAATTTAAAATTGATTAAGTATGCTTATCAGCAAACAAATGGTGAATTTTTAATTATAGGTACAG
GCGGCGTATTCAGTACTGAAGATGCAATCAAAATGATGCGTCACGGTGCGTCACTTATTCAAATTTATTCATCACTTGTT
ATTGAAGGCCCAGGTTTAACTAAGAAAATGAACAAAGGCATCGCACGTTACTTAAAAGATCATCATTTTGACAATGTCAG
TGATATTATAGGACTAGATGCCTAA

Upstream 100 bases:

>100_bases
GAAATTATGTAGGGAAATGCTAGTCTATTAAAAGAATATATTTCACATATATTAAGTTGAGGATAGTAAGCCTCAAATAT
AATGAAATAGGAGCATACTC

Downstream 100 bases:

>100_bases
TCCAACGTAGTCAAATAACACTTTAAAACTTGCTGAATCGTCTTATTAAAATTATGATATAACTCAAGAAGATATATTTA
TCACCATTTTTCAAAATAAT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNPIGLAAGFDKSCEVPKALEH
LGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNNIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYI
KVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDG
IILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLV
IEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA

Sequences:

>Translated_354_residues
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNPIGLAAGFDKSCEVPKALEH
LGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNNIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYI
KVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDG
IILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLV
IEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA
>Mature_354_residues
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNPIGLAAGFDKSCEVPKALEH
LGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNNIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYI
KVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDG
IILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLV
IEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=354, Percent_Identity=35.8757062146893, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=36.1194029850746, Blast_Score=218, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=39.6284829721362, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI281361352, Length=362, Percent_Identity=36.7403314917127, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI17137316, Length=362, Percent_Identity=36.7403314917127, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39567; Mature: 39567

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDN
CCCHHCCHHEEECCCHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHEECCCCCCC
PIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFN
CCCEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
NIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSP
CCCHHHHHHHHHHCCEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDG
CHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCC
IILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTE
EEEECCCCHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
DAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA
HHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCC
>Mature Secondary Structure
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDN
CCCHHCCHHEEECCCHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHEECCCCCCC
PIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFN
CCCEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
NIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSP
CCCHHHHHHHHHHCCEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDG
CHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCC
IILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTE
EEEECCCCHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
DAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA
HHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA