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The map label for this gene is ydgK [H]

Identifier: 15928012

GI number: 15928012

Start: 2494320

End: 2495531

Strand: Direct

Name: ydgK [H]

Synonym: SA2222

Alternate gene names: 15928012

Gene position: 2494320-2495531 (Clockwise)

Preceding gene: 15928011

Following gene: 15928014

Centisome position: 88.61

GC content: 35.07

Gene sequence:

>1212_bases
ATGCAATCAACGAAAACCAAAACGAAGCATTTTTCATTTTTATTGCTAATTACGTTAGGCGTCATGACCGCTTTTGGCCC
ACTAACTATAGATATGTACGTACCATCATTACCTAAAGTGCAAGGTGATTTTGGTTCTACTACATCAGAAATTCAATTAA
CATTATCATTCACAATGATTGGTCTTGCACTAGGCCAATTTATCTTTGGACCTTTATCCGATGCTTTTGGTCGCAAACGG
ATTGCTGTATCCATTTTGATCATTTTCATTTTGGTATCAGGTTTGTCTATGTTTGTTGATCAATTGCCATTATTCTTAAC
TTTACGATTTATTCAAGGTTTAACTGGTGGTGGCGTCATCGTGATTGCCAAAGCCTCTGCTGGTGATAAATTTAGTGGCA
ACGCACTCGCTAAATTTTTAGCATCTTTAATGGTAGTAAATGGCATCATCACTATTCTTGCACCATTAGCTGGTGGATTA
GCTTTATCCGTAGCAACATGGCGTTCTATTTTCACAATTTTAACTATTGTGGCACTCATCATTTTAATTGGCGTCGCTTC
TCAATTACCTAAAACATCTAAAGATGAATTAAAGCAGGTGAATTTTAGTAGCGTCATTAAAGACTTTGGAAGTCTTTTGA
AAAAACCAGCATTTATTATTCCAATGCTATTACAAGGTTTAACTTATGTAATGCTTTTTAGTTATTCATCTGCATCGCCA
TTTATTACTCAAAAATTGTATAATATGACACCCCAACAATTTAGTATCATGTTTGCTGTTAACGGTGTAGGTTTAATCAT
TGTCAGTCAAGTCGTTGCTTTATTAGTAGAAAAATTACATCGCCACATATTATTAATCATTTTAACTATTATACAAGTGG
TGGGTGTTGCTTTAATTATCCTGACACTTACATTCCATTTACCACTTTGGGTCTTACTCATCGCATTCTTCTTAAATGTG
TGTCCTGTGACGTCAATTGGACCACTTGGTTTCACAATGGCTATGGAAGAACGAACAGGTGGCAGTGGTAACGCATCAAG
TTTACTTGGCTTATTCCAATTTATCTTAGGTGGCGCTGTTGCACCATTAGTTGGCTTAAAAGGCGAATTTAATACATCAC
CATATATGATTATTATCTTCATTACAGCCATTCTATTAGTCAGTCTACAAATCATTTACTTTAAAATGATTAAAAAGCAA
CATGTCGCATAA

Upstream 100 bases:

>100_bases
AGTATAGGGATTTTTTATATAAACTTGTATTCTAACTACATACAAATACACACAAAACGTATATAATTTATATAATTATA
TCATTTAAAGGAGTCTGATC

Downstream 100 bases:

>100_bases
CACTTCAACATAATTAGAACCCTAGCAAAGATATCTATCTTTGTCGGGGTTCTTCTTTATGAATTATGAAATCCAATCTT
CAACTAAAATTACGCCTTCA

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMIGLALGQFIFGPLSDAFGRKR
IAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVIVIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGL
ALSVATWRSIFTILTIVALIILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASP
FITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALIILTLTFHLPLWVLLIAFFLNV
CPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAVAPLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQ
HVA

Sequences:

>Translated_403_residues
MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMIGLALGQFIFGPLSDAFGRKR
IAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVIVIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGL
ALSVATWRSIFTILTIVALIILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASP
FITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALIILTLTFHLPLWVLLIAFFLNV
CPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAVAPLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQ
HVA
>Mature_403_residues
MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMIGLALGQFIFGPLSDAFGRKR
IAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVIVIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGL
ALSVATWRSIFTILTIVALIILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASP
FITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALIILTLTFHLPLWVLLIAFFLNV
CPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAVAPLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQ
HVA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=373, Percent_Identity=27.8820375335121, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI48994889, Length=346, Percent_Identity=25.4335260115607, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790794, Length=288, Percent_Identity=25.3472222222222, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790146, Length=157, Percent_Identity=30.5732484076433, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787065, Length=212, Percent_Identity=23.1132075471698, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43451; Mature: 43451

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMI
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHEEEHHHHHHH
GLALGQFIFGPLSDAFGRKRIAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVI
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGLALSVATWRSIFTILTIVALI
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
ILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASP
HHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCH
FITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALII
HHHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLTFHLPLWVLLIAFFLNVCPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHCCCCCCCHHHHHHHHHHHHCCHH
APLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQHVA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMI
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHEEEHHHHHHH
GLALGQFIFGPLSDAFGRKRIAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVI
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGLALSVATWRSIFTILTIVALI
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
ILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASP
HHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCH
FITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALII
HHHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLTFHLPLWVLLIAFFLNVCPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHCCCCCCCHHHHHHHHHHHHCCHH
APLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQHVA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]