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The map label for this gene is fmhA

Identifier: 15927989

GI number: 15927989

Start: 2468026

End: 2469276

Strand: Direct

Name: fmhA

Synonym: SA2199

Alternate gene names: 15927989

Gene position: 2468026-2469276 (Clockwise)

Preceding gene: 15927968

Following gene: 15927996

Centisome position: 87.68

GC content: 33.33

Gene sequence:

>1251_bases
ATGAACTTTGTAACGTTGACTTCGGATGAGTTCAATGCGTTTACAACAAAGCATTTTTCACATTACACACAATCAGCTAT
TCATTACAATCATAGAGTTGATTTAAAAGGCGATGTGCATCTTGTAGGGGTTAAAGATGACAATGGTCAAGTGATTGCAG
GATGCTTATTGACAGAAGCACGCACACTTAAATTTTTCAAATATTTTTATACACATCGCGGGCCAGTGATGGATTATACA
AATCAATCATTAGTAGCATTTTTCTTTAAAGCATTAACGTCATATTTAAAGAAACACAATTGTTTATATGTCCTTGTAGA
TCCATATTTAATTGAAAATTTACGCAATGCAGACGGTGAAATTGTTAAATCTTATGATAACCGAGCATTTGTTAGAACAA
TGGATAAATTAGGTTATAAACACCAAGGTTTCCCTGTAGGTTATGATTCAATGAGCCAAATCCGTTGGCTGTCAGTGTTA
GATTTAAAAGATAAGACTGAAGACCAACTTTTAAAAGAAATGGATTATCAAACGAGACGTAATATTAAAAAAACATATGA
TATTGGTGTCAAAACTAAAACGTTAACGATTGATGAAACGCAAACTTTTTTCGACTTATTCCATATGGCTGAGGAAAAGC
ACGGTTTCAAATTCCGTGAGTTACCATACTTTGAAGAAATGCAAAAGTTATACGATGACCACGCCATGTTAAAGTTGGCG
TATATTGATTTAAACGAGTATTTAAAAACGTTACAATTAAAGCAACAACAATTAACAGCTGAACTCTCAGGTGTTGAAGA
AGCATTGGAAGAAAGTCCTAATTCAAAGAAAAATAAAACGAAACGCACACAGCTAGAACAACAGCTAAATAGCAATAAGC
GTAAAATCGACAATACAATAGAACAAATTGAACAAGATGGTGCAGTCTTAAACTTAGCTTCTGCTTTATTTATCTACAAT
GAGCATGAAGTTTATTACTTATCTAGTGGTTCAAACCCTAAATATAATGCTTATATGGGTGCCTACCATTTGCAGTGGGA
AATGATTAAGTTTGCTAAAGCGCATCATATTGATCGCTATAATTTTTATGGTATTACCGGTGACTATTCAGAGTCATCAG
AAGACTATGGCGTCCAACAATTCAAAAAAGGTTTTAACGCACATGTAGAAGAGTATATCGGTGACTTTATTAAGCCTATC
AAACCATTACTATATAAGGTACAAACGTACTTAAATCATAAACGTCGTTAA

Upstream 100 bases:

>100_bases
TTTTCTATGTGTATTTGTAATCAGTTTTTGATAAAATAAAAAAATAGCATTATTAATAAATTCAAAAATTACAGTTCAAT
TCAGAGAGGGATGGGATAAA

Downstream 100 bases:

>100_bases
AATATCGCTCCAAGATTATGACAACATAACAAAGAACCACGCATCATGTATATGGCATCATCACCATACTAAAACATGAT
ACGTGGTTTTATTTGATTAT

Product: fmhA protein

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance A [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYT
NQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVL
DLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA
YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYN
EHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDYSESSEDYGVQQFKKGFNAHVEEYIGDFIKPI
KPLLYKVQTYLNHKRR

Sequences:

>Translated_416_residues
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYT
NQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVL
DLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA
YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYN
EHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDYSESSEDYGVQQFKKGFNAHVEEYIGDFIKPI
KPLLYKVQTYLNHKRR
>Mature_416_residues
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYT
NQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVL
DLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA
YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYN
EHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDYSESSEDYGVQQFKKGFNAHVEEYIGDFIKPI
KPLLYKVQTYLNHKRR

Specific function: Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. Adds glycines 2 and 3 of the pentaglycine bridge, using glycyl- tRNA(Gly) as donor. Involved in resistance to methicillin [H]

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR003447
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02388 FemAB [H]

EC number: NA

Molecular weight: Translated: 48941; Mature: 48941

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEA
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCEEEHHHHHHH
RTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGE
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCH
IVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRR
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHCHHHHH
NIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA
CCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEE
YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
EQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRY
HHHHHCCCCEEEHHEEEEEECCEEEEEECCCCCCCEEEECEEEHHHHHHHHHHHHCCCCE
NFYGITGDYSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVQTYLNHKRR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEA
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCEEEHHHHHHH
RTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGE
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCH
IVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRR
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHCHHHHH
NIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA
CCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEE
YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
EQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRY
HHHHHCCCCEEEHHEEEEEECCEEEEEECCCCCCCEEEECEEEHHHHHHHHHHHHCCCCE
NFYGITGDYSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVQTYLNHKRR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA