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The map label for this gene is hlb

Identifier: 15927579

GI number: 15927579

Start: 2049532

End: 2050401

Strand: Direct

Name: hlb

Synonym: SA1811

Alternate gene names: 15927579

Gene position: 2049532-2050401 (Clockwise)

Preceding gene: 15927578

Following gene: 15927582

Centisome position: 72.81

GC content: 33.79

Gene sequence:

>870_bases
ATTAGGGACTCCAAACCCAATAAATACTGTTGTTACAAGGTTTCTATGTATCCAAACTGGGGACAATATAAACGCGCTGA
TTTAATCGGACAATCTTCTTATATTAAAAATAATGATGTCGTAATATTCAATGAAGCATTTGATAATGGTGCATCAGACA
AATTATTAAGTAATGTGAAAAAAGAATATCCTTACCAAACACCTGTACTCGGTCGTTCTCAATCAGGTTGGGACAAAACT
GAAGGTAGCTACTCATCAACTGTTGCTGAAGATGGTGGCGTAGCGATTGTAAGTAAATATCCTATTAAAGAAAAAATCCA
GCATGTTTTCAAAAGCGGTTGTGGATTCGATAATGATAGCAACAAAGGCTTTGTTTATACAAAAATAGAGAAAAATGGTA
AGAACGTTCACGTTATCGGTACACATACACAATCTGAAGATTCACGTTGTGGTGCTGGACATGATCGAAAAATTAGAGCT
GAACAAATGAAAGAAATCAGTGACTTTGTTAAAAAGAAAAATATCCCTAAAGATGAAACGGTATATATAGGTGGCGACCT
TAATGTTAATAAAGGCACTCCAGAGTTCAAAGATATGCTTAAAAACTTGAATGTAAATGATGTTCTATATGCAGGTCATA
ATAGCACATGGGACCCTCAATCAAATTCAATTGCGAAATATAATTACCCTAATGGTAAACCAGAACATTTAGACTATATA
TTTACAGATAAAGATCATAAACAACCAAAACAATTAGTCAATGAAGTTGTGACTGAAAAACCTAAGCCATGGGATGTATA
TGCGTTCCCATATTACTACGTTTACAATGATTTTTCAGATCATTACCCAATCAAAGCCTATAGTAAATAG

Upstream 100 bases:

>100_bases
CAATAACTACATCCGTGTATTCTCATTTGTTAGAAGAAAAATTTAATGAAGAGGACAAAAAAACAACTAAAATTTTAGAA
AGTATGTAATTTAGGGACCC

Downstream 100 bases:

>100_bases
TGCTCAACTAACTAATAACTCGCTTCGTTCTAAAAGGACGAAGCGAGTTATATTGTTAAAATTTGAATTGACTTACATTT
TAATAAAATCATCTTAACAA

Product: truncated beta-hemplysin

Products: NA

Alternate protein names: Beta-hemolysin; Beta-toxin; Sphingomyelinase; SMase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKT
EGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRA
EQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYI
FTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK

Sequences:

>Translated_289_residues
MRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKT
EGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRA
EQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYI
FTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
>Mature_289_residues
MRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKT
EGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRA
EQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYI
FTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 33060; Mature: 33060

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVK
CCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCCEECCCCEEEEECCCCCCCHHHHHHHHH
KEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDS
HHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
NKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDET
CCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
VYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYI
EEECCCEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEE
FTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
ECCCCCCCHHHHHHHHHHCCCCCCEEEECEEEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MRDSKPNKYCCYKVSMYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVK
CCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCCEECCCCEEEEECCCCCCCHHHHHHHHH
KEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDS
HHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
NKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDET
CCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
VYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYI
EEECCCEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEE
FTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
ECCCCCCCHHHHHHHHHHCCCCCCEEEECEEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8914839 [H]