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The map label for this gene is serA

Identifier: 15927301

GI number: 15927301

Start: 1765786

End: 1767390

Strand: Direct

Name: serA

Synonym: SA1545

Alternate gene names: 15927301

Gene position: 1765786-1767390 (Clockwise)

Preceding gene: 15927300

Following gene: 15927305

Centisome position: 62.73

GC content: 34.45

Gene sequence:

>1605_bases
ATGAAGCAATTTAATGTACTCGTTGCAGATCCCATATCAAAAGATGGTATCAAAGCATTATTAGATCACGAACAATTCAA
TGTAGATATTCAAACTGGCTTGTCCGAAGAAGCATTAATCAAAATTATACCTTCATACCATGCTTTAATCGTTCGTAGTC
AAACTACGGTTACTGAAAATATCATAAATGCTGCTGATTCTTTAAAAGTAATCGCACGCGCCGGTGTTGGTGTAGATAAT
ATTAATATTAATGCTGCAACATTAAAAGGTATTTTAGTTATTAATGCCCCAGATGGTAATACGATTTCAGCTACTGAACA
TTCACTGGCAATGTTATTATCAATGGCTCGAAATATTCCGCAAGCACACCAATCACTTACAAATAAAGAATGGAATCGAA
ATGCATTTAAAGGTACTGAGCTTTATCATAAAACATTAGGTGTCATTGGTGCTGGTAGAATTGGTTTAGGTGTTGCTAAA
CGTGCGCAAAGTTTCGGAATGAAAATACTAGCTTTTGACCCTTACTTAACGGATGAAAAAGCAAAATCTTTAAGTATTAC
GAAGGCAACAGTTGATGAGATTGCCCAACATTCTGATTTCGTTACATTACATACACCACTAACACCTAAAACAAAAGGCT
TAATTAATGCTGACTTTTTTGCCAAAGCAAAACCTAGTTTGCAAATAATCAATGTGGCACGTGGTGGTATTATTGATGAA
AAGGCGCTAATAAAAGCATTAGACGAAGGACAAATTAGTCGGGCAGCTATCGATGTGTTTGAACATGAACCTGCAACTGA
TTCGCCTCTTGTTGCACATGATAAAATTATTGTTACACCTCATTTGGGTGCATCAACAGTCGAAGCTCAAGAAAAAGTGG
CAATTTCTGTTTCAAATGAAATCATCGAAATTTTAATTGATGGTACTGTAACGCATGCAGTGAATGCACCTAAAATGGAC
TTAAGCAATATAGATGATACTGTAAAATCATTCATCAATTTAAGCCAAACAGTTGGTGAATTAGCTATTCAATTAATGTA
CAATGCACCAAGCTCTATTAAAATTACGTACGGTGGCGACTTAGCCTCTATTGATAGTAGTTTATTAACACGTACAATTA
TTACTCATATTTTAAAAGATGATCTTGGTCCTGAAGTCAATATTATCAATGCTCTAATGTTGTTAAATCAACAACAAGTG
ACATTAAATATTGAAAATAATAAAGCAGAGACAGGTTTTAGTAACTACTTAGAGGTAGAACTATCAAACGATAGCGATTC
CGTTAAAGTTGGCGCTTCTGTCTTTACAGGTTTCGGTCCAAGAATTGTTAGAATTAATAATTTTTCTGTAGACTTAAAGC
CAAATCAATATCAAATTGTGTCATATCATAATGATACTCCAGGTATGGTAGGAAAAACTGGCGCATTGTTAGGTAAATAC
AATATCAACATTGCATCTATGACTTTAGGTAGAACTGAAGCGGGCGGAGATGCGCTAATGATTTTATCCGTTGATCAACC
TGTTTCAAACAATATAATTGATGAACTTAAACAAGTTGGTGAATACAATCAAATTTTCACAACTGAATTGACGGTACAGT
CATAA

Upstream 100 bases:

>100_bases
GATATTTTATCGGTAGTATCTGCTTTAGAAATTATTTTAACTGAACACCGTAAAGTTAACTATATCGGTAAAGGTATATC
AAAATATATGGAGGTTATTC

Downstream 100 bases:

>100_bases
ACAATTTATGTAAATTCAAAATGCCAAGAAGACATTGGATTACTTCCATTGCTTCTTGGCATTTTTTCATTATTAATTTC
ATTGTAACTCAATATGAAAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTENIINAADSLKVIARAGVGVDN
ININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIPQAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAK
RAQSFGMKILAFDPYLTDEKAKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDE
KALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNEIIEILIDGTVTHAVNAPKMD
LSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGDLASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQV
TLNIENNKAETGFSNYLEVELSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKY
NINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS

Sequences:

>Translated_534_residues
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTENIINAADSLKVIARAGVGVDN
ININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIPQAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAK
RAQSFGMKILAFDPYLTDEKAKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDE
KALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNEIIEILIDGTVTHAVNAPKMD
LSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGDLASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQV
TLNIENNKAETGFSNYLEVELSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKY
NINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS
>Mature_534_residues
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTENIINAADSLKVIARAGVGVDN
ININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIPQAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAK
RAQSFGMKILAFDPYLTDEKAKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDE
KALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNEIIEILIDGTVTHAVNAPKMD
LSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGDLASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQV
TLNIENNKAETGFSNYLEVELSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKY
NINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=419, Percent_Identity=39.1408114558473, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI4557497, Length=312, Percent_Identity=33.974358974359, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI61743967, Length=306, Percent_Identity=34.3137254901961, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=29.903536977492, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI145580578, Length=307, Percent_Identity=31.2703583061889, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4557499, Length=307, Percent_Identity=31.2703583061889, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI145580575, Length=307, Percent_Identity=31.9218241042345, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789279, Length=329, Percent_Identity=34.3465045592705, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=33.9483394833948, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=33.6734693877551, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788660, Length=250, Percent_Identity=30.4, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081824, Length=244, Percent_Identity=26.6393442622951, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=312, Percent_Identity=41.9871794871795, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=320, Percent_Identity=29.375, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=336, Percent_Identity=33.3333333333333, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320925, Length=319, Percent_Identity=33.5423197492163, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324055, Length=250, Percent_Identity=28.8, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=28.5185185185185, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=170, Percent_Identity=31.1764705882353, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=43.75, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24646446, Length=311, Percent_Identity=31.5112540192926, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646448, Length=311, Percent_Identity=31.5112540192926, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646452, Length=311, Percent_Identity=31.5112540192926, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646450, Length=311, Percent_Identity=31.5112540192926, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI62472511, Length=311, Percent_Identity=31.5112540192926, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=30.2250803858521, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=26.517571884984, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=25.2365930599369, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=25.2365930599369, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=25.2365930599369, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=25.2365930599369, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=298, Percent_Identity=26.510067114094, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585516, Length=308, Percent_Identity=23.3766233766234, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57621; Mature: 57621

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTEN
CCCEEEEEECCCCCCHHHHHHCCHHEEEEEECCCCCCHHHEECCCCEEEEEECCCHHHHH
IINAADSLKVIARAGVGVDNININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIP
HHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHCCC
QAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTDEK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHCEEEEEECCCCCCCC
AKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDE
CCCEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCH
KALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNE
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCEEEEECCCCCCCCCCCCEEEEEECCE
IIEILIDGTVTHAVNAPKMDLSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGD
EEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCC
LASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQVTLNIENNKAETGFSNYLEVE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEE
LSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKY
ECCCCCCEEECHHHHCCCCCEEEEEECEEEEECCCEEEEEEEECCCCCCCCCCCEEEEEE
NINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS
EEEEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEC
>Mature Secondary Structure
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTEN
CCCEEEEEECCCCCCHHHHHHCCHHEEEEEECCCCCCHHHEECCCCEEEEEECCCHHHHH
IINAADSLKVIARAGVGVDNININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIP
HHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHCCC
QAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTDEK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHCEEEEEECCCCCCCC
AKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDE
CCCEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCH
KALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNE
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCEEEEECCCCCCCCCCCCEEEEEECCE
IIEILIDGTVTHAVNAPKMDLSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGD
EEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCC
LASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQVTLNIENNKAETGFSNYLEVE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEE
LSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKY
ECCCCCCEEECHHHHCCCCCEEEEEECEEEEECCCEEEEEEEECCCCCCCCCCCEEEEEE
NINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS
EEEEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]