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The map label for this gene is srrB

Identifier: 15927072

GI number: 15927072

Start: 1530839

End: 1532605

Strand: Reverse

Name: srrB

Synonym: SA1322

Alternate gene names: 15927072

Gene position: 1532605-1530839 (Counterclockwise)

Preceding gene: 15927073

Following gene: 15927071

Centisome position: 54.45

GC content: 32.94

Gene sequence:

>1767_bases
TTGAGGTTAAATCTAATGATGAGCCGGCTAAATAGTGTCGTAATTAAACTGTGGTTAACTATTATTTTAATAGTGACGAC
AGTTTTAATTTTATTAAGTATTGCTTTAATTACCTTTATGCAATACTATTTCACACAAGAAACCGAAAATGCCATAAGAG
AAGATGCTAGACGTATAAGTTCACTGGTCGAACAATCACATAATAAAGAAGAAGCAATAAAATATAGTCAAACATTAATT
GAAAATCCTGGTGGGTTGATGATTATAAATAATAAACATCGTCAATCAACGGCTTCACTTTCTAATATTAAAAAGCAAAT
GTTGAATGAAGTAGTCAACAACGACCATTTTGACGATGTGTTTGATAAAGGTAAATCTGTTACTCGAAATGTAACGATTA
AAGAAAAGGGTTCATCTCAAACATATATTTTGTTAGGCTATCCAACAAAAGCACAGAAGAATAGTCATAGCAAATATAGT
GGAGTCTTTATATATAAAGACTTGAAATCAATCGAAGATACAAATAATGCTATTACGATTATCACTATAATTACGGCTGT
TATTTTCTTAACAATTACAACAGTCTTTGCGTTTTTCTTATCGTCAAGAATTACAAAACCTTTAAGACGTTTAAGAGACC
AAGCTACACGTGTATCTGAAGGGGATTACTCTTATAAACCTTCTGTCACAACGAAAGATGAAATTGGTCAATTATCGCAG
GCATTTAATCAGATGAGTACAGAAATCGAAGAGCATGTCGACGCATTATCCACATCTAAAAATATTAGAGACAGCTTAAT
TAACTCTATGGTAGAAGGTGTCCTAGGTATTAATGAGAGTCGACAAATTATCTTATCTAATAAGATGGCGAATGATATTA
TGGACAATATTGATGAAGATGCTAAAGCTTTCTTATTAAGACAAATTGAAGATACTTTTAAATCAAAACAAACGGAAATG
CGTGATTTAGAAATGAATGCACGATTCTTTGTTGTGACCACAAGCTATATCGATAAGATTGAACAGGGAGGTAAAAGTGG
TGTTGTTGTGACAGTTCGTGATATGACTAATGAGCACAATCTAGATCAAATGAAGAAAGATTTCATTGCTAATGTATCAC
ATGAATTACGAACACCTATATCATTACTACAAGGTTATACTGAATCAATTGTAGATGGTATTGTTACAGAACCGGATGAA
ATAAAAGAATCGCTCGCCGTTGTCCTTGATGAATCGAAACGTTTAAATCGATTAGTTAATGAATTGTTAAATGTCGCACG
CATGGATGCTGAAGGGTTATCCGTAAATAAAGAAGTTCAGCCTATTGCAGCGTTACTAGATAAGATGAAAATTAAGTATC
GCCAACAAGCTGATGATTTAGGTCTAAATATGACTTTTAATTATTGTAAGAAGCGTGTTTGGAGTTATGATATGGATCGC
ATGGACCAAGTACTAACGAACTTAATTGATAATGCATCACGTTATACGAAACCTGGAGATGAAATTGCAATTACTTGTGA
TGAAAATGAAAGCGAAGATATTTTATACATTAAAGATACAGGCACAGGCATTGCACCAGAACATTTACAACAAGTATTTG
ATCGTTTTTATAAAGTTGATGCAGCGAGAACGCGAGGTAAACAAGGTACCGGTTTAGGTTTGTTCATTTGTAAAATGATT
ATCGAAGAGCATGGTGGTTCCATTGATGTTAAAAGCGAATTAGGAAAAGGCACAACATTTATTATTAAACTACCAAAACC
AGAATAA

Upstream 100 bases:

>100_bases
ACAGTTGATACTCATGTTAAACGACTTAGAGAAAAGTTAAATCGTGTGTCTAGCGAAGCTGCGCATATGATTCAAACAGT
CTGGGGCGTTGGGTATAAAT

Downstream 100 bases:

>100_bases
AACTGAATATAGTTATTTAAGAACGCATGTTATTGATTAGAGACTCTAATTTATAGCATGCGTTTTTTGATTGATGTCGA
AAGTTTTGTAAGTGGATTAG

Product: respiratory response protein SrrB

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MRLNLMMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLI
ENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYS
GVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQ
AFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEM
RDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDE
IKESLAVVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDR
MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMI
IEEHGGSIDVKSELGKGTTFIIKLPKPE

Sequences:

>Translated_588_residues
MRLNLMMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLI
ENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYS
GVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQ
AFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEM
RDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDE
IKESLAVVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDR
MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMI
IEEHGGSIDVKSELGKGTTFIIKLPKPE
>Mature_588_residues
MRLNLMMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLI
ENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYS
GVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQ
AFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEM
RDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDE
IKESLAVVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDR
MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMI
IEEHGGSIDVKSELGKGTTFIIKLPKPE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=336, Percent_Identity=28.2738095238095, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.2869955156951, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=34.3891402714932, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=29.3859649122807, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI48994928, Length=465, Percent_Identity=24.0860215053763, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=30.1255230125523, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=30.6034482758621, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=27.2388059701493, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=28.82096069869, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788549, Length=423, Percent_Identity=24.113475177305, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.0810810810811, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.4261603375527, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=32.7510917030568, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=25.4310344827586, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787374, Length=200, Percent_Identity=24, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=27.7272727272727, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=24.1545893719807, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=25.8333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790567, Length=353, Percent_Identity=25.4957507082153, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=24.8979591836735, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66690; Mature: 66690

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNLMMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDV
HHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITI
HHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHH
ITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHH
AKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHN
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCC
LDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAVVLDESKRLNRLVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
ELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHH
MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
AARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
HHHHCCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MRLNLMMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDV
HHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITI
HHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHH
ITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHH
AKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHN
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCC
LDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAVVLDESKRLNRLVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
ELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHH
MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
AARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
HHHHCCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA