Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 15925934

GI number: 15925934

Start: 267239

End: 268423

Strand: Reverse

Name: fadA [H]

Synonym: SA0223

Alternate gene names: 15925934

Gene position: 268423-267239 (Counterclockwise)

Preceding gene: 15925935

Following gene: 15925932

Centisome position: 9.54

GC content: 43.54

Gene sequence:

>1185_bases
ATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGCGCATTATTCCACGAAAGACC
TGATGATGTCGCAGCCAAAGTATTACAAGGCGTATTGAAACGTATTGACGGAAAATTCAATAAGAATATGATTGAAGATG
TCATTGTTGGTACGGCTTTTCCAGAAGGATTACAAGGACAAAACATTGCACGAACGATTGCATTGCGTGCGGGATTATCT
GACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCGATTGCAGCCAATCAAATTAT
GGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAATTGATGAGTGCCGTACCAATGGGTGGCAACGAGCCCACAA
ACAATCCAACCTTACAATATGATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCATCCCAATTT
GACGTATCACGCGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGACGCACAACGTGATGGTCGGTT
CAAAGATGAAATTATTCCAATACGGGTAAACTCAGTTGAATATACAAACGCAGGACCAAAAGTACACACAAATATCTTTG
ACCAAGATGAATTTATACGCCCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCTGACGGCACT
GTGACTGCGGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCTGGAGATAAAGTGAAAGAACT
AGGCGTGACACCTATTGCACGATTCGTTGGTTATAAGGCAGTAGGCGTTGACCCGAAAATTATGGGTATTGGGCCTGCAT
ATGCGATTCCTGAAGTATTGTCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAAGCATTTGCT
TCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAATGGTGGCGCTATTGCTTTAGG
TCATCCATTAGGTGCTACAGGGGCAATGTTAACCGCGCGTTTACTTAATGAAATGGGTAGACGTCCCGATAGCCGTTACG
GCATGGTTACGATGTGTATTGGTGTCGGCATGGGTGCAGCTGCTATATTTGAGTATGTGCGTTAG

Upstream 100 bases:

>100_bases
TACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAACTGGTAAGCCATTACGTAATTAAAAGATAGTC
ATTAAGAGAGGATGATAACC

Downstream 100 bases:

>100_bases
AATGGTTGATTTTGGATGAAGCGGATTCGTTAGGTTATTGAATGAAGTAGGCTGAAGTTGAAGCGGGTTGAAGCAATTTC
GTTTTATTAATGAAGCTGTG

Product: hypothetical protein

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Sequences:

>Translated_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
>Mature_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=44.2455242966752, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI167614485, Length=360, Percent_Identity=41.1111111111111, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI148539872, Length=387, Percent_Identity=39.5348837209302, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4557237, Length=367, Percent_Identity=35.6948228882834, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=33.7378640776699, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=35.8333333333333, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.3173803526448, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=40.3465346534653, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082165, Length=355, Percent_Identity=40, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=32.6034063260341, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=357, Percent_Identity=40.6162464985994, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=31.4861460957179, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=354, Percent_Identity=34.4632768361582, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=394, Percent_Identity=29.1878172588832, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=321, Percent_Identity=27.7258566978193, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=40, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=31.3106796116505, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.8514851485149, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=41.2921348314607, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24640423, Length=356, Percent_Identity=35.3932584269663, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=33.495145631068, Blast_Score=198, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41849; Mature: 41849

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHC
>Mature Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]