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The map label for this gene is relA

Identifier: 15924624

GI number: 15924624

Start: 1742050

End: 1744239

Strand: Reverse

Name: relA

Synonym: SAV1634

Alternate gene names: 15924624

Gene position: 1744239-1742050 (Counterclockwise)

Preceding gene: 15924625

Following gene: 15924623

Centisome position: 60.59

GC content: 34.25

Gene sequence:

>2190_bases
ATGAACAACGAATATCCATATAGTGCAGATGAAGTTCTTCACAAAGCAAAATCATATTTGTCAGCAGATGAATATGAGTA
TGTTTTAAAAAGCTATCATATTGCTTATGAAGCACATAAAGGTCAGTTCCGAAAAAACGGATTACCATACATTATGCATC
CTATACAAGTTGCAGGTATTTTAACAGAAATGCGATTAGACGGACCGACGATTGTCGCAGGTTTTTTGCATGATGTAATT
GAAGATACACCGTATACATTTGAAGATGTAAAAGAAATGTTCAATGAAGAAGTTGCTCGAATTGTTGATGGTGTGACGAA
GCTTAAAAAAGTAAAATACCGCTCAAAAGAAGAACAACAAGCTGAAAATCATCGCAAGTTATTTATTGCGATTGCCAAAG
ATGTACGCGTAATTTTGGTGAAATTAGCAGACAGATTACATAATATGCGTACCTTGAAAGCCATGCCGCGTGAAAAACAA
ATTAGAATTTCTCGAGAAACATTAGAAATTTATGCACCTTTAGCACATCATCTTGGTATTAATACAATTAAATGGGAACT
AGAAGATACGGCTCTTCGTTATATTGATAATGTGCAATATTTTAGAATAGTCAATTTAATGAAGAAGAAACGTAGTGAAC
GTGAAGCGTATATCGAAACGGCTATTGATAGAATACGTACTGAAATGGACCGAATGAATATCGAAGGCGATATAAATGGT
AGACCTAAACATATTTACAGTATTTATCGGAAAATGATGAAGCAGAAAAAACAATTTGATCAAATTTTTGATTTGTTGGC
GATACGTGTTATTGTCAATTCTATTAATGATTGTTATGCGATACTTGGGTTGGTGCATACGTTATGGAAACCGATGCCAG
GACGTTTTAAAGATTATATTGCAATGCCTAAACAAAATTTGTATCAGTCATTGCATACTACAGTAGTAGGTCCAAATGGA
GACCCGCTCGAAATCCAAATACGAACGTTTGATATGCACGAAATTGCTGAGCATGGTGTTGCAGCACACTGGGCTTACAA
AGAAGGTAAAAAAGTAAGTGAAAAAGATCAAACTTATCAAAATAAGTTAAATTGGTTAAAAGAATTAGCTGAAGCGGATC
ATACATCGTCTGACGCTCAAGAATTTATGGAAACCTTAAAATATGACTTACAGAGTGACAAAGTATACGCATTTACCCCA
GCGAGTGATGTTATTGAGTTGCCATATGGTGCTGTGCCGATTGATTTTGCTTATGCGATTCACAGTGAAGTAGGTAATAA
GATGATTGGTGCCAAGGTGAATGGCAAAATTGTACCAATTGACTATATTTTACAAACAGGCGATATTGTTGAAATACGTA
CTAGTAAACATTCATATGGACCAAGTCGTGATTGGTTGAAAATTGTTAAATCGTCTAGTGCCAAAGGTAAAATTAAAAGT
TTCTTCAAAAAACAAGATCGTTCATCTAATATTGAAAAAGGCCGAATGATGGTTGAAGTTGAAATAAAAGAGCAAGGATT
TAGAGTCGAAGATATTTTGACAGAGAAAAATATTCAGGTTGTTAATGAAAAATATAACTTTGCAAATGAAGATGATTTAT
TCGCAGCTGTAGGATTTGGCGGCGTGACATCCTTACAGATTGTTAATAAATTAACTGAAAGACAACGTATTTTAGATAAA
CAACGTGCTTTAAATGAAGAACAAGAAGTTACGAAATCATTGCCTATTAAAGACAACATCATTACTGATAGTGGTGTCTA
TGTAGAAGGTTTAGAAAATGTACTTATCAAGTTGTCAAAATGTTGTAATCCTATACCAGGTGATGATATTGTAGGTTATA
TCACCAAAGGTCACGGTATTAAAGTACATCGCACTGATTGCCCAAATATTAAGAACGAAACTGAACGACTAATTAATGTT
GAATGGGTAAAATCAAAAGACGCAACTCAAAAATATCAGGTTGATTTAGAGGTAACTGCGTATGACCGAAATGGCTTGTT
GAATGAAGTACTACAAGCTGTTAGCTCGACAGCCGGCAATTTAATTAAAGTTTCAGGACGTTCAGATATTGATAAAAATG
CAATAATAAATATTAGTGTCATGGTGAAAAACGTGAATGATGTTTATCGTGTGGTAGAAAAGATCAAACAACTTGGTGAT
GTTTATACAGTAACAAGAGTTTGGAACTAG

Upstream 100 bases:

>100_bases
CGACGGACGTATGATTGGTGTGGGACAAATACTATTCAACAAGAGTACCTAAATCATTGTTTAAGGCGAAGTAATAAATA
TGAATGGGGTGTATCATATA

Downstream 100 bases:

>100_bases
AGGTGCAAAATATGAAAGTAGTTGTACAAAGAGTTAAAGAAGCATCGGTGACGAATGATACATTAAATAATCAAATCAAA
AAAGGATATTGTTTATTAGT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEVEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEEQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN

Sequences:

>Translated_729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEVEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEEQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN
>Mature_729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEVEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEEQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain

Homologues:

Organism=Homo sapiens, GI38348360, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=39.2458100558659, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1789147, Length=713, Percent_Identity=37.4474053295933, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=38.3458646616541, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24650996, Length=119, Percent_Identity=36.9747899159664, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RELA_STAAM (Q931Q4)

Other databases:

- EMBL:   BA000017
- RefSeq:   NP_372158.1
- ProteinModelPortal:   Q931Q4
- SMR:   Q931Q4
- STRING:   Q931Q4
- EnsemblBacteria:   EBSTAT00000006247
- GeneID:   1121609
- GenomeReviews:   BA000017_GR
- KEGG:   sav:SAV1634
- eggNOG:   COG0317
- GeneTree:   EBGT00050000024882
- HOGENOM:   HBG594146
- OMA:   HRGQKRK
- ProtClustDB:   CLSK885475
- BioCyc:   SAUR158878:SAV1634-MONOMER
- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676
- Gene3D:   G3DSA:3.10.20.30
- SMART:   SM00471
- SMART:   SM00954
- TIGRFAMs:   TIGR00691

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS; SSF81271 TGS-like

EC number: =2.7.6.5

Molecular weight: Translated: 83762; Mature: 83762

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEHHHHHHHH
LTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQ
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGI
HHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHCCC
NTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
CEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQ
HCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCCHHHHHHH
NKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVPIDFAYAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
HSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
HHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
FFKKQDRSSNIEKGRMMVEVEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFG
HHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCC
GVTSLQIVNKLTERQRILDKQRALNEEQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSK
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
CCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQVDLEVTA
HCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEEEEEEEEE
YDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHCC
VYTVTRVWN
EEEEEEECC
>Mature Secondary Structure
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEHHHHHHHH
LTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQ
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGI
HHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHCCC
NTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
CEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQ
HCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCCHHHHHHH
NKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVPIDFAYAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
HSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
HHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
FFKKQDRSSNIEKGRMMVEVEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFG
HHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCC
GVTSLQIVNKLTERQRILDKQRALNEEQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSK
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
CCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQVDLEVTA
HCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEEEEEEEEE
YDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHCC
VYTVTRVWN
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146