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The map label for this gene is rnc

Identifier: 15924223

GI number: 15924223

Start: 1292596

End: 1293327

Strand: Direct

Name: rnc

Synonym: SAV1233

Alternate gene names: 15924223

Gene position: 1292596-1293327 (Clockwise)

Preceding gene: 15924222

Following gene: 15924224

Centisome position: 44.9

GC content: 33.88

Gene sequence:

>732_bases
ATGTCTAAACAAAAGAAAAGTGAGATAGTTAATCGTTTTAGAAAGCGCTTTGATACTAAAATGACAGAGTTAGGCTTTAC
TTATCAAAATATTGATTTATACCAACAAGCATTTTCGCATTCGAGTTTTATTAATGATTTTAATATGAATCGTTTAGACC
ATAATGAGCGTTTAGAGTTTTTGGGTGATGCGGTATTAGAATTGACGGTTTCACGATATTTATTTGATAAACATCCCAAC
TTGCCAGAAGGGAATTTAACAAAAATGCGTGCCACTATTGTATGTGAGCCCTCACTTGTAATATTTGCGAATAAAATTGG
ATTGAACGAAATGATTTTACTTGGTAAAGGTGAAGAGAAAACAGGGGGACGTACAAGACCATCATTAATATCAGATGCAT
TCGAAGCATTTATTGGGGCATTGTATTTGGATCAAGGACTAGATATAGTTTGGAAATTTGCTGAGAAAGTTATTTTCCCA
CATGTAGAACAAAATGAGTTATTAGGCGTGGTAGATTTTAAAACACAATTCCAAGAATATGTGCACCAGCAAAATAAAGG
TGATGTAACCTATAATTTAATAAAAGAAGAGGGACCGGCACATCATCGTCTATTCACTTCAGAAGTTATTCTGCAAGGGG
AAGCAATAGCTGAAGGTAAAGGGAAAACGAAAAAAGAATCAGAACAACGTGCTGCTAAAAGTGCCTATAAGCAATTAAAA
CAAATTAAATAG

Upstream 100 bases:

>100_bases
GGTCGTCAGTATTGTCGACTCAGTTTTTTTCTTTAATTATCAATAGTTTTAACGTAAAATTAAAGATGATTCAAGAGCAA
CACATAAAGGAGATAAAATA

Downstream 100 bases:

>100_bases
AAATTTATATGATACGACATATAGGTGTTCGATTTAGGATTTAAGGAAGAATTTTTAATATTTTATGGAACAACTTCGAA
ATTTAATATACAAATATTAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPN
LPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFP
HVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAKSAYKQLK
QIK

Sequences:

>Translated_243_residues
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPN
LPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFP
HVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAKSAYKQLK
QIK
>Mature_242_residues
SKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNL
PEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPH
VEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAKSAYKQLKQ
IK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=31.2775330396476, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=31.2775330396476, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1788920, Length=241, Percent_Identity=33.195020746888, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=29.3103448275862, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=29.3103448275862, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137682, Length=223, Percent_Identity=28.6995515695067, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_STAA1 (A7X1J9)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441813.1
- ProteinModelPortal:   A7X1J9
- SMR:   A7X1J9
- STRING:   A7X1J9
- EnsemblBacteria:   EBSTAT00000002889
- GeneID:   5559228
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1223
- eggNOG:   COG0571
- GeneTree:   EBGT00050000024553
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   SAUR418127:SAHV_1223-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27921; Mature: 27790

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEF
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEK
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEEECCCEEEEEECCCCCEEEEEECCCCC
TGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
VHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAKSAYKQLK
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
QIK
HCC
>Mature Secondary Structure 
SKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEF
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEK
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEEECCCEEEEEECCCCCEEEEEECCCCC
TGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
VHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAKSAYKQLK
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
QIK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA