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The map label for this gene is argE [C]

Identifier: 15922883

GI number: 15922883

Start: 2559047

End: 2560171

Strand: Direct

Name: argE [C]

Synonym: ST2549

Alternate gene names: 15922883

Gene position: 2559047-2560171 (Clockwise)

Preceding gene: 15922882

Following gene: 15922884

Centisome position: 94.96

GC content: 30.93

Gene sequence:

>1125_bases
GTGATGATTGTTTCGTTATTGAGAGATTTAATAGAAATTCAAACGGTAAATCCACCTGGAAAAGATTATGAAACAATTGT
AAACTATTTGAAGGATTTATTTTCTAGATTAGGATTTAAAACCGAACTTATAACCATACCGGAGGAATACATTGATAAAA
ATTATATTTATTCTCCTCAACATAAAGGATATAAAAGAGTTATACTGATTGTAAAAAATTCTAGAGAACCATTACTTCAT
TTTAATTTTCATTATGACGTAGTTCCACCTGGGGATAATTGGATAACAGAACCGTTTAAACTAAAGATAATTGATAACAA
AGCATTTGGTAGGGGAACGTCAGATATGAAAGGAGCTATAGTTAGCTTATATTTAGCTTTATTAAGGTTCAATGAGACAC
CAATAGAGATCGCCTTTGTTCCCGATGAGGAGAGTGGAGGAATTGGTTCTAAATATTTAACAGAGGAAATCGGAATTAAA
CCTAAGGAGGTAATATTTGGAGAACCTAGCTTCCCAAATATCTACATAGGGCACTACGGTATAATAAGAGGTGTTATAAA
AGTTTTTGGAAAGCAAGTCCATGCAAGCATGGCGAATGAAGGTGTAAATGCATTTCTTGAAGCATCAAAGTTTGCCCTCA
AATTAAATGAAGAACTAAGTAAGAAATATAATATTAATTTGGGCGGATATACTATAAATTCTTCTAATAATGATGGAATA
GTACCAGGATTTTTTGCCTTTAGTTATTATAGGGCTATTTCACCTAATGAAGATAAACTTTTTGATAAGGAGATTGTTGA
CACAGTTTCCAAAGAGTTGGGAATAAATTATGAATTCGAAATAAAATCTGCAATACCAGGATATGTTTCTAAAGAATCAG
ATTTAACTAAGCAACTAGAGTATTGTGTTAAATCTGTTTTAAATATAAACCCAGAAAAATTAGTCAGCAGTCTAAGATAT
GATGCAATATTCTATAAAGATTCTGTTTCAGTGAATTTTGGTCCGGGAGATCCCAAACAAGCACATATAGTGAATGAATA
TATAGAACTAAAAAACATTGAAAAAACTAGTTTAGTCTATGAATATCTGTTGAGGGAAAAAATAAAAAGTTTCAAAAATA
CGTGA

Upstream 100 bases:

>100_bases
TATTTAGAAAAGGGTGGAAAAGTATACGATGAAAACGAGTTAATGGAATTAGAGAGCAAACTAGGTAAATCGAATCTGAT
TAAGGCTAAGAGAGTGTAAA

Downstream 100 bases:

>100_bases
TATGAGAAGAAGGATAAAATTAAAAAATTTTTAAGAAGTAAGTAAAAAAGTTTATTAATTGGAATTGGCTAATAACCCGT
TAGAATGAAGAAACTATACA

Product: succinyl-diaminopimelate desuccinylase

Products: succinate; LL-2,6-diaminoheptanedioate

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MMIVSLLRDLIEIQTVNPPGKDYETIVNYLKDLFSRLGFKTELITIPEEYIDKNYIYSPQHKGYKRVILIVKNSREPLLH
FNFHYDVVPPGDNWITEPFKLKIIDNKAFGRGTSDMKGAIVSLYLALLRFNETPIEIAFVPDEESGGIGSKYLTEEIGIK
PKEVIFGEPSFPNIYIGHYGIIRGVIKVFGKQVHASMANEGVNAFLEASKFALKLNEELSKKYNINLGGYTINSSNNDGI
VPGFFAFSYYRAISPNEDKLFDKEIVDTVSKELGINYEFEIKSAIPGYVSKESDLTKQLEYCVKSVLNINPEKLVSSLRY
DAIFYKDSVSVNFGPGDPKQAHIVNEYIELKNIEKTSLVYEYLLREKIKSFKNT

Sequences:

>Translated_374_residues
MMIVSLLRDLIEIQTVNPPGKDYETIVNYLKDLFSRLGFKTELITIPEEYIDKNYIYSPQHKGYKRVILIVKNSREPLLH
FNFHYDVVPPGDNWITEPFKLKIIDNKAFGRGTSDMKGAIVSLYLALLRFNETPIEIAFVPDEESGGIGSKYLTEEIGIK
PKEVIFGEPSFPNIYIGHYGIIRGVIKVFGKQVHASMANEGVNAFLEASKFALKLNEELSKKYNINLGGYTINSSNNDGI
VPGFFAFSYYRAISPNEDKLFDKEIVDTVSKELGINYEFEIKSAIPGYVSKESDLTKQLEYCVKSVLNINPEKLVSSLRY
DAIFYKDSVSVNFGPGDPKQAHIVNEYIELKNIEKTSLVYEYLLREKIKSFKNT
>Mature_374_residues
MMIVSLLRDLIEIQTVNPPGKDYETIVNYLKDLFSRLGFKTELITIPEEYIDKNYIYSPQHKGYKRVILIVKNSREPLLH
FNFHYDVVPPGDNWITEPFKLKIIDNKAFGRGTSDMKGAIVSLYLALLRFNETPIEIAFVPDEESGGIGSKYLTEEIGIK
PKEVIFGEPSFPNIYIGHYGIIRGVIKVFGKQVHASMANEGVNAFLEASKFALKLNEELSKKYNINLGGYTINSSNNDGI
VPGFFAFSYYRAISPNEDKLFDKEIVDTVSKELGINYEFEIKSAIPGYVSKESDLTKQLEYCVKSVLNINPEKLVSSLRY
DAIFYKDSVSVNFGPGDPKQAHIVNEYIELKNIEKTSLVYEYLLREKIKSFKNT

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=353, Percent_Identity=26.9121813031161, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788816, Length=412, Percent_Identity=23.0582524271845, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789236, Length=169, Percent_Identity=29.585798816568, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.18

Molecular weight: Translated: 42573; Mature: 42573

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIVSLLRDLIEIQTVNPPGKDYETIVNYLKDLFSRLGFKTELITIPEEYIDKNYIYSPQ
CHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCEECCC
HKGYKRVILIVKNSREPLLHFNFHYDVVPPGDNWITEPFKLKIIDNKAFGRGTSDMKGAI
CCCCEEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
VSLYLALLRFNETPIEIAFVPDEESGGIGSKYLTEEIGIKPKEVIFGEPSFPNIYIGHYG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEECCCCCCEEEECHHH
IIRGVIKVFGKQVHASMANEGVNAFLEASKFALKLNEELSKKYNINLGGYTINSSNNDGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEECCCCCCCC
VPGFFAFSYYRAISPNEDKLFDKEIVDTVSKELGINYEFEIKSAIPGYVSKESDLTKQLE
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHH
YCVKSVLNINPEKLVSSLRYDAIFYKDSVSVNFGPGDPKQAHIVNEYIELKNIEKTSLVY
HHHHHHHCCCHHHHHHHHHHCEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
EYLLREKIKSFKNT
HHHHHHHHHHHCCC
>Mature Secondary Structure
MMIVSLLRDLIEIQTVNPPGKDYETIVNYLKDLFSRLGFKTELITIPEEYIDKNYIYSPQ
CHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCEECCC
HKGYKRVILIVKNSREPLLHFNFHYDVVPPGDNWITEPFKLKIIDNKAFGRGTSDMKGAI
CCCCEEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
VSLYLALLRFNETPIEIAFVPDEESGGIGSKYLTEEIGIKPKEVIFGEPSFPNIYIGHYG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEECCCCCCEEEECHHH
IIRGVIKVFGKQVHASMANEGVNAFLEASKFALKLNEELSKKYNINLGGYTINSSNNDGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEECCCCCCCC
VPGFFAFSYYRAISPNEDKLFDKEIVDTVSKELGINYEFEIKSAIPGYVSKESDLTKQLE
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHH
YCVKSVLNINPEKLVSSLRYDAIFYKDSVSVNFGPGDPKQAHIVNEYIELKNIEKTSLVY
HHHHHHHCCCHHHHHHHHHHCEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
EYLLREKIKSFKNT
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-LL-2,6-diaminoheptanedioate; H2O

Specific reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]